关键词：
Bond coat;NiAl;Stability;Mg alloy;Plasma spraying
摘要：
Bond coats play a significant role in manipulating the stability of 8YSZ thermal barrier coatings (TBCs) deposited on Mg alloy. In this study, the metal of Ni-Al mixture was sprayed as bond coat via reaction plasma spraying (RPS). Besides, Intermetallic compound NiAl was prepared by self-propagating high-temperature synthesis (SHS). The pure intermetallic compound NiAl was sprayed as bond coat via atmospheric plasma spraying (APS). The microstructure, composition, bond stability and corrosion resistance of the produced bond coats were investigated to find the optimal bond coat for the TBCs on Mg alloy. Results indicate that the bond coats composed of NiAl show excellent bond stability. High toughness of the RPS Ni-Al bond coat results in high tensile bond strength. The APS NiAl bond coat leads to outstanding thermal shock resistance mainly attributing to its moderate thermal expansion match, good mechanical properties and excellent corrosion resistance. (C) 2017 Elsevier B.V. All rights reserved.
作者：
Combining Gene Expression and Interactions Data with miRNA Family Information for Identifying miRNA-mRNA Regulatory Modules
作者机构：
湖南大学
会议名称：
International Conference on Intelligent Computing
会议时间：
2017-08-06
会议地点：
英国利物浦
关键词：
miRNA-mRNA regulation modules Gene expression miRNA family
摘要：
It is well known that microRNAs (miRNAs) play pivotal roles in gene expression, transcriptional regulation and other important biological processes. An impressive body of literature indicates that miRNAs and mRNAs work cooperatively to form an important part of gene regulatory modules which are extensively involved in cancer. However, with the accumulation of available data, it is a great challenge to identify cancer related miRNA regulatory modules and uncover their precise regulatory mechanism. This paper proposed a novel computational framework by combining gene expression and interaction data with miRNA family information to identify miRNA-mRNA regulatory modules (GIFMRM), which was evaluated on three heterogeneous datasets. Literature survey, biological significance and functional enrichment analysis were used to validate the obtained results. The analysis results show that the modules identified are highly correlated with the biological conditions in their respective datasets, and they enrich in GO biological processes and KEGG pathways.
摘要：
In this paper, a fast factorized backprojection (FFBP) algorithm is proposed for the one-stationary bistatic spotlight circular synthetic aperture radar (OS-BSCSAR) data processing. This method represents the subimages on polar grids in the slant-range plane instead of the ground plane, which can be accurately referenced to the tracks of both transmitter and receiver. It can not only accurately accommodate the complicated circular track including the motion error, scene topographic information, large spatial variances and significant range-azimuth coupling of the echo data, but also improve the imaging efficiency compared with the backprojection (BP) algorithm. First, OS-BSCSAR imaging geometry is provided, and then the bistatic BP algorithm for the OS-BSCSAR imaging is derived to provide a basis for the proposed FFBP algorithm. Second, based on the subaperture imaging model, the polar grids for calculating the subimages are defined, and the sampling requirements for the polar grids are derived from the viewpoint of the bandwidth, which can offer the near-optimum tradeoff between the imaging quality and the imaging efficiency. Finally, implementation and computational burden of the proposed FFBP algorithm is discussed, and then the speed-up factor of the proposed FFBP algorithm with respect to the bistatic BP algorithm is derived. Experiment results are given to prove the correctness of the theory analysis and validity of the proposed FFBP algorithm.
作者机构：
[Peng, Ying-Ying] School of Management and Information Engineering, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China
通讯机构：
[Peng, Y.-Y.] S;School of Management and Information Engineering, Hunan University of Chinese Medicine, Changsha, Hunan, China
关键词：
Broadcast Storm;Internet of Things;Low Energy-Consumption;Routing Protocol
摘要：
How to make large-scale dynamic IoT devices transmit data to other devices via the Internet is an important topic in IoT research. Especially at the same time to avoid radio storms, to adapt to the dynamic environ ment, and with low energy consumption and other features, but there is no practical application of the routing protocol in the real world. This article describes the GFG-L (Greedy Face Greedy for location) routing protocol is a mobile IoT protocol that can meet the above properties, is expected to solve the current dilemma and accelerate the Internet of Things to achieve the pace.
期刊：
International Journal of Performability Engineering,2017年 ISSN：0973-1318
作者机构：
湖南大学
关键词：
Classification;Feature selection;Ensemble learning;Diversity;Mutual information
摘要：
Ensemble feature selection is one of the ensemble learning methods, where each classifier is trained or built by feature selection result. Ensemble feature selection is an effective way for dealing with high dimension and small sample data, such as microarray data. However, ensemble feature selection should achieve more accurate and stable classification performance. In this paper, we present a novel diversity measure based on information theory called Sum of Minimal Information Distance (SMID), which maximizes the relevance between feature subsets and class label as well as the diversity between feature subsets. Moreover, a novel ensemble feature selection framework satisfying this criterion is proposed. In this framework, features that have more mutual information with class label and more diversity
between each other are retained. Different feature subsets are used to train base classifiers after being obtained by incremental search method, and then these classifiers are aggregated into a consensus classifier by majority voting. Comparing with three representative feature selection methods and five ensemble learning methods on ten microarray datasets, the experiment results show that the proposed method achieves better performance than the other methods in terms of the classification accuracy.
作者机构：
[戴瑶; 刘海蓉; 李永生; 黄继英; 邹鹏] College of Materials Science and Engineering, Hunan University, Changsha, 410082, China;[胡薏冰] Hunan Academy of Chinese Medicine, Changsha, 410013, China;[戴瑶; 刘海蓉; 李永生] Hunan Province Key Laboratory for Spray Deposition Technology and Application, Hunan University, Changsha, 410082, China;[周征] College of Biology, Hunan University, Changsha, 410082, China
通讯机构：
College of Materials Science and Engineering, Hunan University, Changsha, China
摘要：
Recommendation systems usually try to “guess” a user’s preferences from the system’s view. We study another side of recommendation: active opinion-formation from the perspec- tive of the user. In real life, a user’s opinion evolves with time and refines when new evidence occurs. Then, how does an online user form his/her own opinion actively in large social networks? The problem has three challenges: the factor, the effect and the open environment. To address those challenges, we investigate: (1) what factors or channels a user will consider, (2) how those channels will take effect, and (3) an incremental approach to incorporate multiple channels. We explore three types of channels: the internal opinion of an individual user, influences from trusted friends, and influences from public channels. A novel simulator, OpinionFormer, is proposed to incorporate those channels incrementally. It differentiates the effects of friends and public channels as well as positive and negative opinions. We validate the performance of OpinionFormer by predicting users’ opinions using real-world data sets. Experimental results show that our model can improve accuracy over other models that ignore some channels or that neglect the evolving features.
作者机构：
[Liu, Bin; Fan, Jialong; Zhao, Chuan; Liu, Xuanming; Tong, Chunyi] Hunan Univ, Hunan Prov Key Lab Plant Funct Genom & Dev Regula, Coll Biol, Changsha 410082, Hunan, Peoples R China.;[Wang, Wei; Chen, Yanjiao] Hunan Univ Chinese Med, Sch Pharm, Sinoluxemburg TCM Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.;[Fang, Jun] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Liu, Bin; Wang, Wei] H;Hunan Univ, Hunan Prov Key Lab Plant Funct Genom & Dev Regula, Coll Biol, Changsha 410082, Hunan, Peoples R China.;Hunan Univ Chinese Med, Sch Pharm, Sinoluxemburg TCM Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.
摘要：
As a widely used deoxyribonuclease, DNase I is involved in many physiological processes including tumor cell proliferation, metastasis and apoptosis. Furthermore, the level of this enzyme in serum can act as a functional biomarker for the therapeutic monitoring of systemic lupus erythematosus and other diseases. We report here a low cost and sensitive DNase I detecting system based on the single-stranded fluorogenic substrate and nanographene oxide (NGO) and use it for DNase-targeted natural product screening. The system with a detection limit of 0.005 U was then used to evaluate the effect of external factors on DNase I. The results show that Hg2+, As2+, Pb2+, Cd2+ and Cu2+ can inhibit DNase I activity in a concentration-dependent manner with IC50 values of 0.37 mM (Hg2+), 2.7 mM (As2+), 5 mM (Pb2+), 5.3 mM (Cd2+) and 7.8 mM (Cu2+), respectively. Meanwhile, 10 natural compounds isolated from Cyclocarya paliurus leaves were screened as DNase I inhibitors, while 5 compounds were identified as activators. Finally, the system was used to discriminate DNase activity of serum samples with and without HBV. The results showed that HBV infection significantly decreased the level of DNase I in serum samples. In summary, these data indicate that this method with the advantages of rapidity, low cost and high sensitivity is hopeful for DNase assay in biological samples as well as compound screening in vitro.
作者机构：
[Chen, Nai-hong; Wang, Zhenzhen; Zhang, Shuai; Chen, Jiao; Chu, Shifeng] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.;[Chen, Nai-hong; Wang, Zhenzhen; Zhang, Shuai; Chen, Jiao; Chu, Shifeng] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.;[Chen, Nai-hong; Wang, Zhenzhen; Zhang, Shuai; Chen, Jiao; Chu, Shifeng] Peking Union Med Coll, Beijing 100050, Peoples R China.;[Ai, Qidi; Chen, Nai-hong] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.;[Chen, Nai-hong] Guangzhou Univ Chinese Med, Guangzhou 510000, Guangdong, Peoples R China.
通讯机构：
[Chen, Nai-hong] C;[Chen, Nai-hong] P;[Chen, Nai-hong] H;[Chen, Nai-hong] G;Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.
摘要：
Stress plays a crucial role in the development of major depressive disorder, but the molecular mechanism underlying the susceptibility vs. resilience to stress remains unclear. To better understand these mechanisms, we used chronic unpredictable mild stress to develop a depressive rat model. We categorized them into stress resistant rats and stress sensitive rats by their performance in behavioral tests, including forced swim test and sucrose preference test. Brain regions were dissected, and prefrontal cortex (PFC) proteins extracted from stress resistant and stress sensitive rats were analyzed using label-free liquid chromatography-tandem mass spectrometry. Three hundred and four proteins were up-regulated and 323 proteins were down-regulated among the 1482 different proteins from stress resistant rats compared with that of the stress sensitive rats. Western blotting, immunohistochemical staining and electron microscopy were used to validate the results of the proteomic analysis. Some proteins differentially expressed in stress resistant and sensitive rats were found to be associated with several neurobiological processes, particularly with neurotransmission regulation. The results provide possible novel insights into the molecular mechanisms for stress resilience.
期刊：
Agro Food Industry Hi-Tech,2017年28(3):1316-1319 ISSN：1722-6996
通讯作者：
Yi, Fayin
作者机构：
[Yi, Fayin; Yin, Hongliang] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.
通讯机构：
[Yi, Fayin] H;Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.
关键词：
Tennis player;rotator cuff injury;rehabilitation training
摘要：
Most rotator cuff injuries of tennis players are chronic, which means that it would take a long time and be difficult for them to bring the injury under permanent control. Affected by the injury, their abilities in sports and careers would be affected. Currently, it has become a hot topic for rehabilitation researchers to study how we can improve the performance of injured rotator cuffs in a short time, and how we can ensure the training quality of injured tennis players. The author checked up on the rotator cuff muscle force and the condition of shoulder muscles of tennis players in sports colleges, offered rational and effective rehabilitation training plans, and evaluated their rehabilitation conditions. This study could support formulating rational rehabilitation training plans through data, so as to improve the rehabilitation performance of injured tennis players.
摘要：
Combined with the fundamental theorems of thermodynamics and the heat radiation theory, Pennes bioheat equation is improved, which can describe the thermal process in tissue subject to heat stimulation of moxibustion more vividly. Applying the Green function method, we derive the analytical solution of the equation and establish a straightforward way to quantitatively interpret the temperature behavior of living tissues, such as healthy tissue, tumor tissue, non-acupoint tissue and acupoint tissue, as a result of moxibustion. The concept of temperature attenuation coefficient (TAC) is proposed to measure the energy absorption at different depth of tissue. The coherence between the simulation and experiment about surface temperature demonstrates the flexibility and availability of the solution. The oscillation energy flow has a mild stimulus to the biological tissues, which is an advantageous physical exciter for organization to achieve its good functions. Our results reveal that the heat with high frequency is mainly absorbed by the surface layer, while that of low frequency can deeply penetrate into the living biological parts. Significantly, the diseases can be treated by moxibustion heat through the role of deep penetration.
