期刊：
Journal of Drug Targeting,2024年32(1):1-20 ISSN：1061-186X
通讯作者：
Zhang, Liang;Ai, K
作者机构：
[Qu, Qirui; Zhang, Liang; Zhao, Lingyun; Wu, Qingze; Ai, Kun; Qi, Fang; Ai, K; Zhang, L] Hunan Univ Chinese Med, Coll Acupuncture & Tuina & Rehabil, Changsha 410208, Peoples R China.;[Long, Yiying] Hunan Tradit Chinese Med Coll, Zhuzhou, Peoples R China.;[Liu, Li] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Peoples R China.
通讯机构：
[Ai, K ; Zhang, L] H;Hunan Univ Chinese Med, Coll Acupuncture & Tuina & Rehabil, Changsha 410208, Peoples R China.
关键词：
Rheumatoid arthritis;angiogenesis;miR based therapeutics;microRNAs;therapeutic target
摘要：
Vascular neogenesis, an early event in the development of rheumatoid arthritis (RA) inflammation, is critical for the formation of synovial vascular networks and plays a key role in the progression and persistence of chronic RA inflammation. microRNAs (miRNAs), a class of single-stranded, non-coding RNAs with approximately 21-23 nucleotides in length, regulate gene expression by binding to the 3' untranslated region (3'-UTR) of specific mRNAs. Increasing evidence suggests that miRNAs are differently expressed in diseases associated with vascular neogenesis and play a crucial role in disease-related vascular neogenesis. However, current studies are not sufficient and further experimental studies are needed to validate and establish the relationship between miRNAs and diseases associated with vascular neogenesis, and to determine the specific role of miRNAs in vascular development pathways. To better treat vascular neogenesis in diseases such as RA, we need additional studies on the role of miRNAs and their target genes in vascular development, and to provide more strategic references. In addition, future studies can use modern biotechnological methods such as proteomics and transcriptomics to investigate the expression and regulatory mechanisms of miRNAs, providing a more comprehensive and in-depth research basis for the treatment of related diseases such as RA.
摘要：
BACKGROUND: Post-stroke spasticity (PSS) is the most common complication of stroke. Acupuncture is widely used in clinical practice for the treatment of PSS, and is therefore considered a common complementary treatment. Several systematic reviews (SRs) and meta-analyses (MAs) have demonstrated the efficacy and safety of acupuncture in the treatment of PSS; however, the quality of evidence of these studies has not been adequately assessed. OBJECTIVE: To evaluate and summarize the SRs/MAs and inform future research and clinical practice on the efficacy and safety of acupuncture for PSS. DATA SOURCES AND EXTRACION: The following databases were searched from their dates of inception to March 26, 2023: PubMed, Embase, The Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, SinoMed, and Chinese Science and Technology Periodical Database (VIP), and grey literature were manually searched. Two reviewers independently completed literature retrieval, screening, and data extraction. REVIEW APPRAISAL: Systematic evaluation tools to Assess Systematic Reviews (AMSTAR) 2, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020 Checklist), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system were used to systematically evaluate the methodological, reporting, and evidence quality of the SRs/MAs. RESULTS: Overall, 226 papers were examined, and after careful consideration, 10 SRs/MAs were deemed eligible for inclusion. The AMSTAR 2 assessment revealed that one SR/MA had medium, one study had low, and the remaining eight studies had critically low methodological qualities. Additionally, four SRs/MAs completed more than 60 % of the PRISMA 2020 checklist. The GRADE system indicated that six outcomes were medium, 26 outcomes were low, and 24 outcomes were critically low. CONCLUSION: Based on the evidence, acupuncture may be a promising complementary treatment to improve post-stroke spasticity and quality of life. Further high-quality RCTs are needed in future studies to support the broader application of acupuncture for the treatment of PSS.
作者机构：
[Liu, Xiaowei; Chen, Qintao; Zhang, Siyi; Liu, Lei; Gong, Zhichao] College of Acupuncture, Massage and Rehabilitation, Hunan University of Chinese Medicine, Changsha, Hunan, China;[Gao, Yinyan; Liu, Wenqi] Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China;[Li, Wu; Li, Jiangshan] College of Acupuncture, Massage and Rehabilitation, Hunan University of Chinese Medicine, Changsha, Hunan, China 272434694@qq.com 292463008@qq.com
摘要：
INTRODUCTION: Neck pain is a common problem that severely affects physical and mental health. While musculoskeletal manipulations are recommended as the first-line treatment for adults with neck pain, the comparative effectiveness of different musculoskeletal manipulations remains unclear. This systematic review and network meta-analysis of randomised controlled trials (RCTs) will compare the effectiveness of different types of musculoskeletal manipulations, with the overarching aim of guiding clinical practice. METHODS AND ANALYSIS: Two independent reviewers will search four English electronic databases (Web of Science, Cochrane Library, EMBASE, PubMed) and three Chinese electronic databases (China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang) for relevant RCTs published from 1 January 2013 to 30 April 2023. The Clinical Trials Registry (ClinicalTrials.gov) will be searched for completed but unpublished RCTs. English and Chinese will be used to search English databases and Chinese databases, respectively. RCTs of musculoskeletal manipulations for adults (aged ≥18 years) with neck pain will be considered eligible for inclusion. A pairwise meta-analysis and network meta-analysis will be performed, and pooled risk ratios, standardised mean differences and 95% CIs will be determined. ETHICS AND DISSEMINATION: Ethics approval is not required as this study is a literature review. The results of this review will be published in peer-reviewed journals or disseminated at conferences. PROSPERO REGISTRATION NUMBER: CRD42023420775.
摘要：
BACKGROUND: The objective of this bibliometric inquiry was to scrutinize domains that delve into the repercussions of the 2019 coronavirus disease (COVID-19) pandemic on individuals afflicted with autism spectrum disorder (ASD), worldwide scholarly findings of interrelated research, and forthcoming trajectories. METHODS: To conduct a literature analysis, use the web of science core collection database, search for ASD and COVID-19-related literature published Utilize CiteSpace and VosViewer to visually analyze documents and create networks of authors, organizations. The CiteSpace and VosViewer to visually analyze documents and create networks of authors, organizations, countries, and keywords. RESULTS: This study collected 771 papers and shows an increasing trend in publications. The United States had the most relevant literature (281), followed by the United Kingdom (115) and Italy (76). The United States had the most relevant literature (281), followed by the United Kingdom (115) and Italy (76). The University of London had the most papers (53, 6.87%), and Happe_Francesca was the most productive researcher (6). J AUTISM DEV DISORD was the main journal for research on the impact of COVID-19 on ASD, with 22 related articles. Keyword co-occurrence analysis has revealed that "parenting stress," "enhancing adherence," "acute stress disorder," "COVID-19 Italian lockdown," "neurodevelopmental disorder," and "occupational therapy" have garnered significant attention recently. Notably, the burst keywords suggest that "interventions," "qualitative research," "Disabilities Monitoring Network," "neurodevelopmental disabilities," "perceived stress," and "barriers" are potential areas of investigation for future research. CONCLUSION: This bibliometric analysis delineates the fundamental structure for assessing the impact of COVID-19 on ASD by scrutinizing crucial indicators such as Our analysis reveals that COVID-19 impact on autism has garnered the interest of an Future research could explore the stress, anxiety, and strategies for individuals with ASD and their The use of telemedicine can be studied in depth, as a new idea for ASD diagnosis and intervention training, it is worthwhile. The use of telemedicine can be studied in depth, as a new idea for ASD diagnosis and intervention training, it is worth exploring, such as Disabilities Monitoring Network, etc.
作者机构：
[熊罗节] College of Acupuncture-Moxibustion, Tuina and Rehabilitation, Hunan University of CM, Changsha 410208, China;[Zhai, Chun-Tao; 李玮; 田岳凤; 徐小珊] Second Clinical College, Shanxi University of CM, Jinzhong 030619
作者机构：
[Liu, Yu; Yue, ZH; Wang, Shaohua; Pan, Sian; Yuan, Hanyu; Yue, Zenghui; Li, Juan; Xue, Xiao] Hunan Univ Chinese Med, Coll Acupuncture Massage & Rehabil, Changsha, Peoples R China.;[Liu, Xin; Xue, Xiao] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Dept Chinese Med, Heng Yang, Hunan, Peoples R China.
通讯机构：
[Liu, Y; Yue, ZH ] H;Hunan Univ Chinese Med, Coll Acupuncture Massage & Rehabil, Changsha, Peoples R China.
摘要：
BACKGROUND: Primary dysmenorrhea in women is a common and serious public health problem with psychological and physical effects. Painkillers have adverse effects, such as tolerance, addiction, irritation of the digestive tract, and liver and kidney damage. Electroacupuncture has been used as alternative therapy, although with no (non-anecdotal) evidence of effectiveness. OBJECTIVE: This study aims to provide evidence for the feasibility and efficacy of electroacupuncture in the treatment of primary dysmenorrhea. Moreover, by observing changes in serum and urine metabolites, we will evaluate the putative mechanisms mediating electroacupuncture effects in primary dysmenorrhea. METHODS: This multicenter, randomized, participant-blinded, sham-controlled clinical trial including 336 women with primary dysmenorrhea is being conducted at three hospital centers in China and consists of a 12-week treatment and a 3-month follow-up. Women will undergo electroacupuncture (n = 168) or sham acupuncture (n = 168), beginning 7 days before their menstruation, once per day, until menstruation. Each menstrual cycle equals one course of treatment, and we will evaluate a total of three courses of treatment. The primary outcome of interest is the change in visual analogue scale scores before and after treatment. The secondary outcomes include changes in the numeric rating scale, Cox Menstrual Symptom Scale, traditional Chinese medicine symptoms, the Self-Rating Anxiety Scale, Self-Rating Depression Scale, and 36-Item Short Form questionnaire scores, and a safety evaluation. Moreover, we will preliminarily investigate the metabolomics mechanism as a potential mediator of the association between electroacupuncture and primary dysmenorrhea symptomology. DISCUSSION: We aim to find a suitable non-medicinal alternative for primary dysmenorrhea treatment to reduce reliance on non-steroidal anti-inflammatory drugs. TRIAL REGISTRATION: Chinese Clinical Trial Registry: ChiCTR2100054234; http://www.chictr.org.cn/.
作者机构：
[肖逸] College of Acupuncture-Moxibustion, Tuina and Rehabilitation, Hunan University of CM, Changsha 410208, China. 452672548@qq.com;[周竞颖; 刘倩; 尹鸿智; 钟欢] College of Acupuncture-Moxibustion, Tuina and Rehabilitation, Hunan University of CM, Changsha 410208, China;[罗容] Department of Acupuncture-Moxibustion, Tuina and Rehabilitation,First Affiliated Hospital of Hunan University of CM;[刘未艾] Department of Acupuncture-Moxibustion, Tuina and Rehabilitation, Second Affiliated Hospital of Hunan University of CM;[杜革术] Department of Acupuncture-Moxibustion and Rehabilitation, Changsha Hospital of TCM
作者机构：
[潘思安] College of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China. pansian1989@126.com;[潘思安] College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208. pansian1989@126.com;[刘余; 袁菡钰; 李娟; 汪少华; 薛晓] College of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China;[岳增辉] College of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China. yue5381316@126.com. LA - eng
摘要：
Stroke is the third leading cause of death and disability worldwide. Post-stroke spasticity (PSS) is the most common complication of stroke but represents only one of the many manifestations of upper motor neuron syndrome. As an upper motor neuron, the corticospinal tract (CST) is the only direct descending motor pathway that innervates the spinal motor neurons and is closely related to the recovery of limb function in patients with PSS. Therefore, promoting axonal remodeling in the CST may help identify new therapeutic strategies for PSS. In this review, we outline the pathological mechanisms of PSS, specifically their relationship with CST, and therapeutic strategies for axonal regeneration of the CST after stroke. We found it to be closely associated with astroglial scarring produced by astrocyte activation and its secretion of neurotrophic factors, mainly after the onset of cerebral ischemia. We hope that this review offers insight into the relationship between CST and PSS and provides a basis for further studies.
期刊：
Mediators of Inflammation,2023年2023:9377518 ISSN：0962-9351
通讯作者：
Zhang, Junyi;Jiang, WH
作者机构：
[Xie, Shaobing; Zhang, Junyi; Zhang, Hua; Jiang, Sijie; Jiang, Weihong; Xie, Zhihai] Cent South Univ, Dept Otolaryngol Head & Neck Surg, Xiangya Hosp, Changsha, Peoples R China.;[Xie, Shaobing; Zhang, Junyi; Zhang, Hua; Jiang, Sijie; Jiang, Weihong; Xie, Zhihai] Cent South Univ, Hunan Prov Key Lab Otolaryngol Crit Dis, Xiangya Hosp, Changsha, Peoples R China.;[Xie, Shaobing; Zhang, Junyi; Zhang, Hua; Jiang, Sijie; Jiang, Weihong; Xie, Zhihai] Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Xiangya Hosp, Changsha, Peoples R China.;[Tang, Qingping] Hunan Univ Chinese Med, Brain Hosp Hunan Prov, Dept Rehabil, Changsha, Peoples R China.
通讯机构：
[Zhang, JY; Jiang, WH ] C;Cent South Univ, Dept Otolaryngol Head & Neck Surg, Xiangya Hosp, Changsha, Peoples R China.;Cent South Univ, Hunan Prov Key Lab Otolaryngol Crit Dis, Xiangya Hosp, Changsha, Peoples R China.;Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Xiangya Hosp, Changsha, Peoples R China.
关键词：
Introduction;Materials and Methods;Results;Discussion;Conclusion;Abstract;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interests;Authors’ Contributions;Funding Statement;Acknowledgements;Acknowledgments;Supplementary Materials;Reference;Dataset Description;Dataset Files;Abstract;Introduction;Introduction and Materials;Introduction and Methods;Materials;Materials and Methods;Methods;Results;Discussion;Results and Discussion;Discussion and Conclusion;Results and Conclusion;Conclusion;Conclusions;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interest;Authors’ Contributions;Funding Statement;Acknowledgements;Supplementary Materials;References;Appendix;Abbreviations;Preliminaries;Introduction and Preliminaries;Notation;Proof of Theorem;Proofs;Analysis of Results;Examples;Numerical Example;Applications;Numerical Simulation;Model;Model Formulation;Systematic Palaeontology;Nomenclatural Acts;Taxonomic Implications;Experimental;Synthesis;Overview;Characterization;Background;Experimental;Theories;Calculations;Model Verification;Model Implementation;Geographic location;Study Area;Geological setting;Data Collection;Field Testing;Data and Sampling;Dataset;Literature Review;Related Works;Related Work;System Model;Methods and Data;Experimental Results;Results and Analysis;Evaluation;Implementation;Case Presentation;Case Report;Search Terms;Case Description;Case Series;Background;Limitations;Additional Points;Case;Case 1;Case 2 etc.;Concern Details;Retraction Details;Copyright;Related Articles
摘要：
BACKGROUND: Intralymphatic immunotherapy (ILIT) is short-course administration of allergen-specific immunotherapy (AIT). This study is aimed at assessing the clinical efficacy and safety of ILIT in patients with allergic rhinitis (AR). METHODS: MEDLINE, PUBMED, and Cochrane Library were used to conduct electronic searches for clinical trials comparing ILIT and placebo in patients with AR. The final search took place on August 24, 2022. Cochrane Handbook for Systematic Reviews of Interventions was used to assess the risk of bias in the included studies. The outcomes included combined symptom and medication scores (CSMS), visual analog scale (VAS), allergic rhinoconjunctivitis quality of life (RQLQ), Skin-prick test (SPT), and adverse events (AEs). Data were synthesized as mean difference (MD)/standard mean difference (SMD) or risk difference (RD) and 95% confidence interval (CI). RESULTS: Thirteen studies (454 participants) were included in this study. The ILIT group had better clinical improvement on the CSMS (random effects model, SMD-0.85, 95% CI [-1.58, -0.11], P = 0.02) and RQLQ (fixed-effects model, MD-0.42, 95% CI [0.69, 0.15], P = 0.003) than the placebo group. The booster injection was beneficial for CSMS (P < 0.0001), and the 4-week injection interval was superior to the 2-week injection period for improving VAS (P < 0.0001). Local swelling or erythema was the main AE following injection (random effects model, RD 0.16, 95% CI [0.05, 0.27], P = 0.005). Discussion. For individuals with AR, ILIT is safe and effective. ILIT alleviates clinical symptoms and reduces pharmaceutical consumption without causing severe AEs. However, the validity of this study is compromised by the substantial heterogeneity and risk of bias in the included researches. RegistrationCRD42022355329.
作者机构：
[潘思安; 刘余; 袁菡钰; 李娟; 岳增辉; 汪少华; 薛晓] College of Acupuncture-Moxibustion, Tuina and Rehabilitation, Hunan University of CM, Changsha 410208, China;[薛晓] Department of TCM, First Affiliated Hospital of University of South China
作者机构：
[何灏龙; 刘红华; 刘琼; 钟欢; Zhong, Huan; 常小荣] College of Acupuncture-Moxibustion & Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China;[刘密; 肖山峰] Department of Acupuncture-Moxibustion & Tuina, Rehabilitation and Pain, Liuyang Hospital of Traditional Chinese Medicine, Liuyang 410300, Hunan Province;[刘密] Key Laboratory of Acupuncture Bioinformatics, Hunan University of Chinese Medicine, Changsha 410208
作者机构：
[Xiong, Luo-jie] Hunan Univ Chinese Med, Coll Acupuncture Massage & Rehabil, Changsha 410208, Peoples R China.;[Tian, YF; Zhai, Chun-tao; Tian, Yue-feng; Li, Wei] Shanxi Univ Chinese Med, Clin Coll 2, Jinzhong 030619, Shanxi, Peoples R China.
通讯机构：
[Tian, YF ] S;Shanxi Univ Chinese Med, Clin Coll 2, Jinzhong 030619, Shanxi, Peoples R China.
关键词：
acupuncture and moxibustion;Chinese materia medica;immune checkpoint;autoimmune disease;tumor
摘要：
Immunotherapy targeting immune checkpoint molecules has emerged as a key approach in cancer treatment, representing the forefront of antitumor research. However, studies on immune checkpoint molecules have mainly focused on targeted therapies. Chinese medicine (CM) research as a complementary medicine has revealed that immune checkpoint molecules also undergo disease-specific changes in the context of autoimmune diseases. This review article presents a comprehensive analysis of CM studies on immune checkpoint molecules in the last 5 years, with a focus on their role in different diseases and treatment modalities. CM research predominantly utilizes oral administration of herbal plant extracts or acupuncture techniques, which stimulate the immune system by activating specific acupoints through temperature and needling. In this study, we analyzed the modulation and mechanisms of immune checkpoint molecules associated with different coinhibitory and costimulatory molecules, and reviewed the immune functions of related molecules and CM studies in treating autoimmune diseases and tumors. By summarizing the characteristics and research value of CM in regulating immune checkpoint molecules, this review aims to provide a useful reference for future studies in this field.
作者机构：
[谢灿明] School of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China. 1511729734@ qq. com;[江姗姗] Rehabilitation Center of the Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061;[王瑶; 刘晓月; 陈楚淘; 向静] School of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China;[田浩梅] School of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China. 451358104@qq.com. LA - eng
作者机构：
[来奕恬; 刘密; 周竞颖; 任玲; 张国山] College of Acupuncture-moxibustion and Tuina & Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China
作者机构：
[许明] College of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China. 004588@hnucm.edu.cn;[艾坤; 李亚; 匡静之; 刘琼; 陈晓雯; 邓石峰; 展立芬] College of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China;[张泓] College of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China. zh5381271@sina.com. LA - eng
关键词：
memory disorder;meta-analysis;protocol;Repetitive transcranial magnetic stimulation;stroke
摘要：
Background: Approximately 23% to 55% of patients have memory impairments with a greatly negative effect on daily life 3 months after stroke. Repetitive transcranial magnetic stimulation (rTMS) has been widely used in the rehabilitation of stroke as it is safe, painless, and noninvasive. Moreover, few studies have investigated the effect of rTMS on poststroke memory disorder (PSMD). However, the efficacy of rTMS is not consistent and the optional stimulation frequency is unclear. Therefore, this protocol aims to evaluate the clinical effect and safety of rTMS on PSMD by analyzing results from randomized controlled trials. Methods: Search strategies will be performed on seven databases: PubMed, EMBASE, CENTRAL, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), Wan Fang, and Technology Periodical Database (VIP). Only randomized controlled trials registered before August 2021 will be included. Additionally, the language will be limited to English or Chinese. For the outcome, we will focus on the Rivermead Behavioral Memory Test. Additionally, the Montreal Cognitive Assessment, Mini-mental State Examination, Modified Barthel Index, and advent events will be included. Two authors will independently select the study, extract data, and assess quality. Moreover, disagreements will be resolved by the third author. STATA 14 and Review Manager 5.4 will be used to perform the analysis. We will evaluate bias risk in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. To assess the quality of evidence, the Grading of Recommendations Assessment, Development, and Evaluation method will be employed. Results: This study will provide a comprehensive analysis of the current evidence on rTMS for PSMD. Conclusion: A reliable conclusion regarding whether rTMS is an effective and safe intervention for patients with PSMD and the effect of stimulation frequency and sham stimulation will be provided. This study will provide new insights for TMS in treating PSMD, and offer appropriate treatmentoptions to patients and clinicians. PROSPERO registration number: CRD42021282439.
作者机构：
[张泓; 熊丹; 谢菊英; Qiu, Rong-Rong; 邓畅; 谭洁; Deng, Chang; 徐雅钰] School of Acupuncture-Message and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China
作者机构：
[来奕恬; 周竞颖; 丁攀婷] Graduate School of Hunan University of Chinese Medicine, Changsha 410208, China;[刘密; 李南; 张国山] College of Acupuncture-moxibustion-Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208;[邱冉冉] The First Hospital of Hunan University of Chinese Medicine, Changsha 410007
