摘要：
Despite the promising prospect of small interfering RNA（siRNA） for the treatment of diverse diseases,it remains challenging to develop novel delive ry materials to desired tissues and cells.In this study,a novel iron oxyhydroxide（FeOOH） nanoparticle（NP） whose surface was modified with branched polyetherimide（PEI） was developed to deliver siRNA into the cancer cells.It was demonstrated that PEI-FeOOH（PFeOOH） efficiently complexed siRNA,mediated effective cellular uptake and endosomal escape,thereby triggering robust gene silencing in vitro.In addition,PFeOOH/siRNA formulation loading with anti-RRM2 siRNA effectively inhibited the growth of tumor tissues,and exhibited excellent safety profiles in vivo.Therefore,this study conceptually provided a FeOOH-based nucleic acid delivery vesicle which can potentially use to achieve diagnosis and therapy simultaneously.
作者机构：
[Li, Kun; Huang, Yuanyu; Lu, Mei] Beijing Inst Technol, Adv Res Inst Multidisciplinary Sci, Sch Life Sci, Inst Engn Med,Key Lab Mol Med & Biotherapy, Beijing 100081, Peoples R China.;[Xia, Xinhua; Huang, Yuanyu] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.
通讯机构：
[Mei Lu; Yuanyu Huang] S;School of Life Science, Advanced Research Institute of Multidisciplinary Science, Institute of Engineering Medicine, Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing 100081, China<&wdkj&>School of Life Science, Advanced Research Institute of Multidisciplinary Science, Institute of Engineering Medicine, Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing 100081, China<&wdkj&>School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
摘要：
As a new treatment technique, photothermal therapy (PTT) has aroused worldwide attention in cancer treatment, mainly due to its excellent absorption ability, easy regulation, and biodegradability. Photothermal conversion materials with enhanced permeability and retention effect can be targeted easily to tumor tissue. They can accumulate efficiently to tumor tissues and allow normal tissues and organs not to be affected by temperature, thus significantly helping to reduce the systemic toxicity and improve the antitumor effect. However, PTT alone often suffers from therapeutic resistance and reduced therapeutic efficacy, due to photothermal nanomaterial-mediated fundamental cellular defense mechanism of heat shock response, which could be inhibited by small interfering RNA (siRNA). Nevertheless, photothermal conversion materials as an excellent siRNA delivery carrier may considerably enhance the delivery efficiency of siRNA. Therefore, photothermal and RNA interfering (RNAi) synergistic therapy has recently aroused extensive attention in tumor treatment. In this review, we mainly summarize the recent advances of photothermal and RNAi synergistic therapy, including some synergistic therapeutic nanoplatforms of inorganic and organic photothermal materials and other combined therapies such as combining with small molecular antitumor agents or PDT/imaging. The combination of various treatment techniques may considerably improve the synergistic therapeutic effect of PTT and RNAi in the treatment of cancers.
作者机构：
湖南中医药大学药学院,湖南长沙410208;中药成药性与制剂制备湖南省重点实验室,湖南长沙410208;湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208;[潘雪; 周逸群; 李海英; 陈定芳; 周燕子; 贺玉婷; 王敏存] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, 410208, China;[贺福元] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, 410208, China, Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[Zhou, Y.-Q.; He, F.-Y.] C;College of Pharmacy, China
作者机构：
[Zeng N.; 彭彩云; 王炜; 姚旺; 李斌; 姚清颖] TCM and Ethnomedicine Innovation & Development International Laboratory, Sino-Pakistan TCM & Ethnomedicine International Cooperation Base, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China;[段淑莉] Jinan University, Guangzhou, 510632, China;[王思成] Chukochen Honors College, Zhejiang University, Hangzhou, 310012, China;[张在其] Hunan Provincial Key Laboratory of Dong Medicine, Hunan University of Medicine, Huaihua, 418000, China
通讯机构：
[Zhang, Z.-Q.] H;[Peng, C.-Y.] T;Hunan Provincial Key Laboratory of Dong Medicine, China;TCM and Ethnomedicine Innovation & Development International Laboratory, China
作者机构：
湖南中医药大学药学院,湖南长沙410208;中药成药性与制剂制备湖南省重点实验室,湖南长沙410208;湖南省中药饮片标准化及功能工程技术研究中心,湖南长沙410208;中国医学科学院北京协和医学院药物研究所,北京 100050;[杨岩涛] School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Druggability and Preparation of Chinese Medicine Key Laboratory of Hunan Province, Changsha, 410208, China, Center for Standardization and Functional Engineering of Traditional Chinese Medicine in Hunan Province, Changsha, 410208, China
作者机构：
湖南中医药大学药学院,湖南长沙410208;湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208;中药成药性与制剂制备湖南省重点实验室,湖南长沙410208;[杨岩; 肖佳妹] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Laboratory of Supramolecular Mechanism and Mathematic-Physics Characteristic of Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China;[贺福元; 杨岩涛] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Laboratory of Supramolecular Mechanism and Mathematic-Physics Characteristic of Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Key Laboratory of Druggability and Preparation of Chinese Medicine, Changsha, 410208, China
作者机构：
[王敏存; 周燕子; 贺福元; 李海英; 潘雪; 陈定芳; 吴月峰; 周逸群] Laboratory of Supramolecular Mechanism and Mathematic-physics Chracterization for Traditional Chinese Medicine, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Chinese Materia Medica, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[Zhou, Y.-Q.; He, F.-Y.] L;Laboratory of Supramolecular Mechanism and Mathematic-physics Chracterization for Traditional Chinese Medicine, China
作者机构：
湖南中医药大学药学院,湖南长沙410208;中药成药性与制剂制备湖南省重点实验室,湖南长沙410208;常德市第一中医医院,湖南常德415000;湖南中医药大学中西医结合学院,湖南长沙410208;[刘文龙] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Changsha, 410208, China, Changde First Hospital of Traditional Chinese Medicine, Changde, 415000, China
通讯机构：
[Zhang, X.-L.; Ge, J.-W.] C;College of Integrated Traditional Chinese and Western Medicine, China;College of Pharmacy, China
