作者机构：
[任婷; 李正阳; 黄政德; 童巧珍] College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China;[黄新艳] Hengyang Hospital of Traditional Chinese Medicine .Hengyang, Nephropathy Dept, Hunan, 421001, China;Hunan Key Lab of Tcm Prescription and Syndromes Translalional Medicine, Changsha, 410208, China;[吴若霞] College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China, Hengyang Hospital of Traditional Chinese Medicine .Hengyang, Nephropathy Dept, Hunan, 421001, China, Hunan Key Lab of Tcm Prescription and Syndromes Translalional Medicine, Changsha, 410208, China;[田雪飞] College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Key Lab of Tcm Prescription and Syndromes Translalional Medicine, Changsha, 410208, China
摘要：
Objective To observe the effects of Sanxue Mingmu Tablets (散血明目片) combined with conbercept on patients with wet age-related macular degeneration (wAMD).Methods A total of 70 patients with wAMD were randomly divided into a treatment group with 35 cases (51 eyes) and a control group with 35 cases (50 eyes). The control group was treated with intravitreal injection of conbercept 0.05 ml once a month for three times. The treatment group was additionally treated with oral Sanxue Mingmu Tablets 2.4 g each time, three times a day for three months. The best corrected visual acuity (BCVA), electroretinogram (ERG) amplitude and latency of a wave and 6 wave of the 2 groups were observed before treatment and 1 month, 2 months, 3 months after treatment. Ultrasound was used to detect the peak systolic short-velocity (PSV), end-diastolic flow (EDV), and resistance index (RI) of the posterior ciliary short arteries in the 2 groups of patients. Optical coherence tomography (OCT) was used to detect the macular foveal thickness (CMT). The postoperative complications and the recurrence of 6 months follow-up after treatment were observed.Results Compared with the previous time point within group, the BCVA in both groups was significantly decreased after 1, 2, and 3 months of treatment (P<0.05). When the amplitudes of a wave and b wave, RI, and CMT were compared at all time point in the 2 groups, the differences were statistically significant (P<0.05). There was a statistically significant difference in the EPG a-wave, b-wave amplitude, RI, and CMT between groups after 1, 2, and 3 months of treatment (P<0.05). Compared with in group before treatment, except for PSV after 1 month in the control group, there was a statistically significant difference in PSV and EDV after treatment for 1, 2, and 3 months between groups (P<0.05). The differences between PSV at 2 and 3 months after treatment and EDV at 1, 2, and 3 months after treatment were statistically significant (P<0.05). Conjunctival hyperemia occurred in 1 eye in the treatment group and 2 eyes in the control group after surgery. There was no significant difference in complications between groups (P>0.05). There were 4 cases (5 eyes) relapsed in the treatment group, with a recurrence rate of 11.11%, and 11 patients (15 eyes) relapsed in the control group, with a recurrence rate of 34.09%. The recurrence rate of the treatment group was lower than that of the control group.Conclusion Sanxue Mingmu Tablets combined with Combercept ophthalmic injection can promote the absorption of retinal exudation and bleeding after wAMD, improve vision, and have a good effect on wAMD.
作者机构：
[邓乐; 梁力伟; 丁长松; 黄辛迪] School of Informatics and Engineering, Hunan University of Chinese Medicine, Changsha, 410208, China;[梁昊] Institute of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[Ding, C.-S.] S;School of Informatics and Engineering, China
关键词：
药向量;中药药性量化;BP神经网络;药性数据;功效
摘要：
目的 为解决中药药性描述的抽象、模糊导致难以准确把握其本质特性的问题,提出一种基于多层前馈神经网络(BP 神经网络)的药向量训练(quantitative model of traditional Chinese medicine's properties based on BP neural network,QM-BP)模型,实现中药药性的量化表示.方法 首先对中药及其对应的功效进行整理,获得“中药-功效”样本对;其次,构建“中药-药向量-功效”3层结构的QM-BP模型,并利用中药的药性数据对模型进行初始化;最后,基于QM-BP模型使用“中药-功效”样本进行训练,得到BP药向量.结果 将《中药学》教材所涉及的474味中药及其528个功效基于QM-BP模型训练并结合临床分析,发现训练后得到的BP药向量比药性的初始量化值更能反映中药的属性特征.此外,由于BP药向量与词向量具有相似的性质,发现功效相似的药物对应的BP药向量在欧几里得距离中距离较近,而功效差异较大的中药药向量在欧几里得距离中距离较远.结论 利用BP神经网络构建药向量训练模型,在中药药性与功效具有关联性的基础上,对药性量化值进行修正,以期使药性量化值更精确.今后可优化QM-BP模型并开展药对、复方分析,以期探明中药药性及组方配伍中蕴藏的内在规律.
作者机构：
[丁长松; 黄辛迪; 梁力伟] School of Informatics, Hunan University of Chinese Medicine, Changsha, 410208, China;[梁昊] Institute of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, 410208, China;[蔡雄] Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[Ding, C.-S.] S;School of Informatics, China
作者机构：
[罗雁威; 刘乐平; 桂嵘] Department of Blood Transfusion, Third Xiangya Hospital, Central South University, Changsha, 410006, China;[曹学帅; Long X.; 徐昕怡] College of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine, Changsha, 410006, China
通讯机构：
[Gui, R.] D;Department of Blood Transfusion, Third Xiangya Hospital, Central South University, Changsha, China
