通讯机构:
[Zhou, J.; Ren, F.; Zhu, L.] D;[Huang, G.] H;Hernia and Abdominal Wall Surgery Center, China;Department of Gastrointestinal Hernia Surgery, China;Department of Geriatric Surgery, China
作者机构:
[肖荣; 熊涛; 王平; 陈纯静; 赵澄; 张香港; 胡珏] Medical College, Hunan University of Traditional Chinese Medicine, Changsha, 410208, China;The First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha, 410208, China;[卢芳国] Medical College, Hunan University of Traditional Chinese Medicine, Changsha, 410208, China, The First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha, 410208, China
通讯机构:
[Lu, F.-G.] M;[Lu, F.-G.] T;Medical College, China;The First Affiliated Hospital, China
作者机构:
[方闯; 匡泓俊; 曹洋; 夏叶婉] Postgraduate School of Hunan University of Chinese Medicine, Changsha 410208, China;[钟峰; 章薇; 罗容] Department of Acupuncture and Tuina Rehabilitation, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007;[文钱] Department of Traditional Chinese Medicine, Huaihua Hospital of Traditional Chinese Medicine, Huaihua 418099, Hunan Province
作者机构:
[Qiaoyu L.; Zhi L.; Yongjie T.] Department of Anesthesiology, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410021, China;[Yali G.; Youjing S.; Ju G.] Department of Anesthesiology, Affiliated Clinical Medical College, Yangzhou University Northern Jiangsu People's Hospital, Yangzhou, 225000, China
通讯机构:
[Youjing, S.] D;Department of Anesthesiology, China
作者机构:
[侯芬; 李平; 李波] Department of Radiology, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China;[李恒国] Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China;[周智凤; 刘霞] Neuropsychiatric Imaging Center, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, 518000, China;[胡运涛] Guangzhou School for the Blind, Guangzhou, 510000, China
通讯机构:
[Liu, X.] N;Neuropsychiatric Imaging Center, China
作者机构:
[Chuang FANG; Yang CAO; Dou XIAO; Chao KE; Zi-qing NIU; Ye-wan XIA] Hunan University of Chinese Medicine, Changsha, Hunan 410007, China(湖南中医药大学, 湖南 长沙 410007, 中国);[Jiang PAN; Wei ZHANG] The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China(湖南中医药大学第一附属医院, 湖南 长沙 410007, 中国)
通讯机构:
[Wei ZHANG] T;The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China(湖南中医药大学第一附属医院, 湖南 长沙 410007, 中国)
摘要:
Objective: To summarize the acupoint selection rule for chronic gastritis treated with acupuncture and moxibustion so as to provide a certain evidence for clinical practice and scientific research.Methods: By searching journal literature on chronic gastritis treated with acupuncture and moxibustion in recent 10 years, with data mining, the acupoints screened from literature were analyzed .Results: A total of 803 articles were included finally. Conception vessel, stomach meridian and bladder meridian were mostly selected, the acupoints were selected from the abdomen, the thigh/crus, the back and the arms. The top 5 aucpoints with high frequency were Zúsānl? (足三里ST36), Zhōngw?n (中脘CV12), Wèishū (胃俞BL21) (332), Píshū (脾俞BL20) and Nèiguān (内关PC6). The top 5 acupoint combinations with high frequency included CV12 combined with ST36, BL21 with CV12, BL21 with ST35 and BL20 with CV12. The mostly used specific points were front-mu point, he-sea point, crossing point and back-shu point.Conclusion: In treatment of chronic gastritis with acupuncture and moxibustion, conception vessel, stomach meridian and bladder meridian are particularly selected in combination and the specific points with duplicate effect are mostly selected, especially focusing on the application of front-mu point.
作者机构:
[陈新宇; 刘起立; 姚昆鹏; 张道平] Hunan University of Chinese Medicine,,The First Affiliated Hospital of Hunan University of Chinese Medicine;[陈青扬; 蔡虎志] The First Affiliated Hospital of Hunan University of Chinese Medicine
关键词:
急性心肌梗死;中药;生物信息学
摘要:
采用Gene Expression Omnibus(GEO)数据集联合机器学习研究急性心肌梗死(acute myocardial infarction,AMI)的差异基因,并预测具有调控作用的潜在成分及中药。从GEO数据...展开更多 采用Gene Expression Omnibus(GEO)数据集联合机器学习研究急性心肌梗死(acute myocardial infarction,AMI)的差异基因,并预测具有调控作用的潜在成分及中药。从GEO数据库下载AMI的人类全基因组数据集(GSE66360和GSE61145),以GSE66360作为测试集,通过R语言的normalize Between Arrays包进行校正后,再调用limma包获取差异基因(DEGs),对DEGs作Gene Ontology(GO)、Kyoto Encyclopedia of Genes and Genomes(KEGG)、Disease Ontology(DO)富集分析;采用SVM及随机森林树法筛选特征基因,利用GSE61145数据集对得出的特征基因进行验证;通过CTD数据库找到AMI特征基因所对应的中药成分,利用Coremine数据库映射中药成分所对应的中药,并依据《中药大辞典》、《中华本草》、《中国药典》等对所得中药的频次、四气、五味、归经进行汇总。通过对GSE66360数据集进行分析,得到317个差异基因,其中306个上调,11个下调,GO和KEGG富集分析显示AMI的差异基因主要涉及中性粒细胞介导的炎症和免疫反应、脂代谢异常、脂质和动脉粥样硬化相关通路等,DO富集分析表明差异基因与动脉硬化性心血管疾病、肺部疾患等密切相关。通过SVM及随机森林树法得到6个特征基因:ZFP36、GADD45A、PELI1、METRNL、MMP9、CXCL16。CTD映射到成分97种,Coremine数据库映射到中药824味,汇总后发现治疗AMI的中药以甘、苦、温为主,多归于脾、胃、肝经。经汇总后,调控AMI的特征基因(ZFP36、GADD45A、PELI1、METRNL、MMP9、CXCL16)成分主要有苯并[a]芘,四氯二苯二氧芑,对乙酰氨基酚等,中药有茶树根、郁金、人参等,其性味为甘、苦、温,归经多为脾、胃、肝经。收起
作者:
BI Dingyan;LI Hongliang;HE Dao;CAO Jianan;OUYANG Lizhi;...
期刊:
针灸推拿医学:英文版,2022年20(5):370-375 ISSN:1672-3597
通讯作者:
Zhan Yi
作者机构:
Hunan University of Chinese Medicine, Changsha, China;The First Hospital of Hunan University of Chinese Medicine, Changsha, China;Yueyang Hospital of Traditional Chinese Medicine, Yueyang, China;[YI Zhan; LIU Huijuan; BI Dingyan; CAO Jianan; WANG Jing; OUYANG Lizhi] Hunan University of Chinese Medicine,Changsha 410208,China;[HE Dao] Yueyang Hospital of Traditional Chinese Medicine,Yueyang 414000,China
通讯机构:
[Zhan Yi] H;Hunan University of Chinese Medicine, Changsha, China
摘要:
Objective: To observe the efficacy of herbal cake-partitioned moxibustion for lumbar disc herniation (LDH) due to kidney deficiency and blood stasis and observe the influence of this method on lumbar functions and inflammatory factors in patients with this condition. Methods: A total of 120 LDH patients who met the inclusion criteria were randomly divided into three groups, including a herbal cake-partitioned moxibustion group, a flour cake-partitioned moxibustion group, and a Western medication group, with 40 patients in each group. The patients in the Western medication group were treated with diflunisal tablets, 0.5 g per dose, 2 doses a day. Those in the herbal cake-partitioned moxibustion group were treated with additional herbal cake-partitioned moxibustion group at Back-Shu Points and Jiaji (EX-B2) Points once a day. Those in the flour cake-partitioned moxibustion group were treated with the same methods as in the herbal cake-partitioned moxibustion group, except that the herbal cake was replaced by a flour cake. All the patients were treated for 10 d. After treatment, the scores of the visual analog scale (VAS) and Japanese Orthopaedic Association (JOA) and the changes of the interleukin (IL)-6, tumor necrosis factor (TNF)-α, and substance P (SP) levels were observed, and the efficacy was evaluated. Results: After treatment, the VAS score and the levels of IL-6, TNF-α, and SP were lower than those before treatment, and the JOA score was higher than that before treatment in the three groups, indicating intra-group statistical significance (P<0.05). The VAS score and the levels of IL-6, TNF-α, and SP of the herbal cake-partitioned moxibustion group were lower than those of the flour cake-partitioned moxibustion group and the Western medication group, while the JOA score of the herbal cake-partitioned moxibustion group was higher than that of the other two groups, indicating inter-group statistical significance (P<0.05). The total effective rate of the herbal cake-partitioned moxibustion group was 92.5%, higher than that of the flour cake-partitioned moxibustion group (80.0%) and the Western medication group (72.5%), indicating inter-group statistical significance (P<0.05). Conclusion: On the basis of Western oral medication, additional herbal cake-partitioned moxibustion can alleviate the pain and improve the lumbar functions in patients with LDH due to kidney deficiency and blood stasis. The efficacy of the integrated method is better than that of either flour cake-partitioned moxibustion or Western medication alone, which may be related to the reduction of serum inflammatory factors.
作者机构:
[何业文; 李平; 罗慕晴; 颜路悠; 黎建宇; 张堃; 刘音其] Department of Radiology, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China;[向辉春; 李宏伟] Department of Radiology, Huaihua Hospital of Traditional Chinese Medicine, Huaihua, 418099, China
通讯机构:
[Zhang, K.] D;Department of Radiology, China