作者机构：
[陈魏; 李莹; 潘诗敏; 李金香; 胡莎; 张罗琴; 张曦] Department of Acupuncture-Moxibustion and Tuina, the First Affiliated Hospital of Hunan University of CM, Changsha 410007, China;[陈魏; 李莹; 潘诗敏; 张罗琴; 张曦] Graduate School of Hunan University of CM, Changsha 410208
作者机构：
[廖菁; 余黄合; 杨珍] Institute of Innovation and Applied Research in Chinese, Medicine Hunan University of Chinese Medicine, Changsha, 410208, China;[李鑫; 丁长松] Hunan Provincial Key Lab of Diagnostic and Therapeutic Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China;[唐琳] School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, China;[刘良] State Key Lab of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, 999078, China;[林也; 张婷] Institute of Innovation and Applied Research in Chinese, Medicine Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Provincial Key Lab of Diagnostic and Therapeutic Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
Key Laboratory of Internal Medicine of Chinese Medicine, First Affi Liated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, China
作者机构：
[Quan-rui Jiang; Jiang-shan Li; Xiao-wei Liu; Jun Yu] Hunan University of Chinese Medicine, Changsha, China;[Si-hong Chen; Xiao-ping Li; Wu Li] The First Hospital of Hunan University of Chinese Medicine, Changsha, China
通讯机构：
[Wu Li] T;The First Hospital of Hunan University of Chinese Medicine, Changsha, China
作者机构：
[Chi Zhang] College of Acupuncture & Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha, China;[Jian Zhang; Cheng-xi Wang] Hengyang Hospital of Traditional Chinese Medicine, Hengyang, China;[Ran-ran Qiu; Jiang Pan] The First Hospital of Hunan University of Chinese Medicine, Changsha, China;[Guo-shan Zhang] College of Acupuncture & Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Hengyang Hospital of Traditional Chinese Medicine, Hengyang, China
通讯机构：
[Cheng-xi Wang] H;Hengyang Hospital of Traditional Chinese Medicine, Hengyang, China
摘要：
Objective: To analyze and summarize the commonalities and patterns in acupoint selection for moxibustion treatment of asthma. Methods: Data retrieval was conducted using ‘moxibustion’ and ‘asthma’ as the keywords through China National Knowledge Infrastructure (CNKI), Wanfang Academic Journal Full-text Database (Wanfang) and Chongqing VIP Database (CQVIP). Excel 2010 was used to establish the major acupoint database for moxibustion prescriptions in treatment of asthma; data mining methods including association patterns and clustering were adopted to analyze the characteristics and patterns in acupoint selection for moxibustion treatment of asthma. Results: A total of 161 moxibustion prescriptions were recruited. The most commonly used acupoint was Feishu (BL 13), the most commonly used meridian was the Bladder Meridian of Foot Taiyang, and the most commonly treated region was the back. The association rule analysis showed that Feishu (BL 13)-Dazhui (GV 14)-Fengmen (BL 12) had the most significant correlation, and the clustering analysis discovered 5 effective acupoint clusters. Conclusion: In moxibustion treatment of asthma, topical acupoints Feishu (BL 13), Dazhui (GV 14) and Fengmen (BL 12) can be selected, along with the acupoints from the Bladder Meridian of Foot Taiyang and the back.
作者机构：
[朱鼎铭; 王超; 谭成富; 刘薇薇; 杜琳; 唐雅妮; 郭礼娜; 陈美琳; 李姣兰] College of Acupuncture-moxibustion and Massage, Hunan University of Chinese Medicine, Changsha 410007, China;[章薇] Department of Acupuncture and Moxibustion of the First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha 410007
作者机构：
[Gu, Qianbiao] Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013;[Liu, Peng; Gu, Qianbiao] Department of Radiology, People's Hospital of Hunan Province, First Affiiated Hospital, Hunan Normal University, Changsha 410002, China;[Feng, Zhichao; Ma, Mengtian; Rong, Pengfei; Yan, Haixiong] Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013, China;[Hu, Xiaoli] First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China;[Mustafa Jumbe, Mwajuma] Department of Radiology, Muhimbili National Hospital, Dar es Salaam 65000, Tanzania
通讯机构：
Department of Radiology, Third Xiangya Hospital, Central South University, Changsha, China
作者机构：
[樊启猛; 刘惠; 李海英; 李小林; 陈思阳; 贺鹏] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China;Hunan Provincial Key Laboratory of Druggability and Preparation Modification of TCM, Changsha, 410208, China;Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China;The First Affinity Hospital, Hunan University of Chinese Medicine, Changsha, 410007, China;[黄胜] Jiuzhitang Co., Ltd., Changsha, 410205, China
通讯机构：
[Liu, P.-A.] H;Hunan Provincial Key Laboratory of Druggability and Preparation Modification of TCM, Changsha, China
作者机构：
[赵洪庆; 黄会珍; 金狮; 凌佳; 罗薇絮; 王宇红; 孟盼; 柳卓] Hunan University of Chinese Medicine, State Key Laboratory Breeding Base of Chinese Medicine Powder and Innovative Medicine, Changsha, 410208, China
通讯机构：
[Wang, Y.-H.] H;Hunan University of Chinese Medicine, State Key Laboratory Breeding Base of Chinese Medicine Powder and Innovative Medicine, Changsha, China
关键词：
百合疏肝安神汤;焦虑性抑郁症;海马;杏仁核;神经营养因子
摘要：
目的:探讨百合疏肝安神汤对焦虑性抑郁模型大鼠海马神经元-杏仁核神经营养因子表达的影响。方法: 72只SD大鼠随机分为空白组、模型组、文拉法辛组( 6.75 mg·kg~(-1)) 、百合疏肝安神汤高、中、低( 18.72,9.36和4.68 g·kg~(-1))剂量组。采用慢性束缚应激联合皮质酮注射( 30 mg·kg~(-1))的方法建立焦虑性抑郁动物模型,于造模同时灌胃( ig)给药,持续21 d。高架十字迷宫测试和强迫游泳实验分别评价大鼠的焦虑和抑郁样行为,高效液相色谱-电化学法检测海马-杏仁核单胺递质5-羟色胺( 5-hydroxytryptamine,5-HT) 、多巴胺( dopamine,DA) 、去甲肾上腺素( norepinephrine,NE)的含量,苏木精-伊红( HE)染色法观察海马-杏仁核组织形态变化,蛋白印迹法检测海马-杏仁核脑源性神经营养因子( brain-derived neurotrophic factor,BDNF) 、神经生长因子( nerve growth factor,NGF)及神经营养因子-3( neurotrophin-3,NT-3)的表达。结果:与空白组比较,模型组大鼠总穿臂次数、进入开臂次数及停留时间均明显下降( P < 0.01),强迫游泳不动时间显著增加( P < 0.01),焦虑抑郁样行为明显,海马、杏仁核组织病理损伤明显,单胺递质含量显著下降( P < 0.01),神经营养因子表达显著降低( P < 0.01);给予高剂量的百合疏肝安神汤干预后,模型大鼠的焦虑抑郁样行为明显改善( P < 0.01),海马、杏仁核病理损伤有所缓解,单胺递质含量升高( P < 0.01或P < 0.05),神经营养因子表达上调( P < 0.01或P < 0.05) 。结论:百合疏肝安神汤能显著改善大鼠的焦虑抑郁行为,缓解海马-杏仁核损伤,其作用与升高单胺递质含量、上调神经营养因子的表达有关。
