作者机构：
[申震; 潘成熙; 周富强; 朱付平] Dept of Orthopedics, First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China;[黄勇; 范仪铭] Dept of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Luoyang, 471000, China
作者机构：
[向韵; 孟盼; 赵洪庆; 柳卓] National Key Lab Breeding Base of Chinese Medicine Powder and Innovative Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China;[杨蕙] Central Lab, First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China;[王宇红] National Key Lab Breeding Base of Chinese Medicine Powder and Innovative Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China, Central Lab, First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China
作者机构：
[向彪; 蒋司晨; 欧阳林旗; 魏凤; 邓桂明] The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China;[肖小芹] The College of Integrated Traditional Chinese and Western medicine of Hunan University of Chinese Medicine, Changsha, 410208, China;[朱青; 刘景诗] Department of Pharmacy, The Affiliate Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China
通讯机构：
[Ouyang, L.-Q.] T;The First Hospital of Hunan University of Chinese Medicine, Changsha, China
作者机构：
[魏凤; 欧阳林旗] Department of Pharmacy, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, 410007, China;[王胜峰; 刘世坤] Department of Pharmacy, The Third Xiangya Hospital of Central South University, Changsha, 410013, China;[黄利华] Medical Center Laboratory, The Third Xiangya Hospital of Central South University, Changsha, 410013, China;[黄娟娟] The First Hospital of Changsha, Changsha, 410005, China
通讯机构：
[Liu, S.-K.] D;Department of Pharmacy, China
作者机构：
[周湘乐; 黄艳芳; 胡金辉; 李平; 蒋博; 谭非易; 杨宇] Department of Radiology, First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha 410007, China
作者：
Cao Miao;Deng Fang-fang;Yuan Qun;Zhang Ji-dong;He Qing-hu;...
期刊：
针灸推拿医学：英文版,2018年16(4):236-242 ISSN：1672-3597
通讯作者：
Qing-hu He
作者机构：
Hunan University of Chinese Medicine, Changsha, 410208;The First Hospital of Hunan University of Chinese Medicine, Changsha, 410021;Institute of Basic Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700;[Cao Miao; Yuan Qun; He Qing-hu] Hunan University of Chinese Medicine, Changsha, 410208;[Deng Fang-fang] The First Hospital of Hunan University of Chinese Medicine, Changsha, 410021
通讯机构：
[Qing-hu He] H;Hunan University of Chinese Medicine, Changsha, China
摘要：
Objective: To systematically evaluate the therapeutic efficacy of tuina therapy for primary insomnia. Methods: Nine Chinese and English databases were searched from the inception to May 2017 to identify randomized controlled trials (RCTs) studying tuina therapy for insomnia. The enrolled articles were all RCTs with tuina as the monotherapy or major therapy in the experiment group, with clear diagnostic criteria for primary insomnia well recognized worldwide or in China, and Pittsburgh sleep quality index (PSQI) as one of the outcome measures. Two researchers evaluated the risk of bias and quality of the enrolled studies by following Cochrane Handbook version 5.1.0. The meta-analysis was performed by RevMan version 5.3. Results: Eleven studies were included with a total of 1 076 participants. The Western medication adopted in the control groups were benzodiazepine receptor agonists. The studies were all assessed as high risk of bias for blinding since blinding method was unable to be performed due to the specificity of tuina therapy; no study reported the support of fund or potential interest conflict, so they were all rated unclear for selective reporting. The meta-analysis showed that compared with other traditional Chinese medicine therapies, tuina worked more effectively in reducing the PSQI score (MD=-4.11<0, 95% confidence interval (CI) -6.01 to -2.22, P<0.0001); compared with oral administration of Western medication, tuina showed more significant efficacy in reducing the PSQI score (MD=-3.42<0, 95%CI -5.19 to -1.66, P<0.0001). Subgroup analysis showed that head tuina alone showed no significant difference compared with oral administration of Western medication regarding the change of PSQI score (MD=-4.19<0, 95%CI -8.87 to 0.50, P>0.05); a combination of head and back tuina could more effectively reduce the PSQI score compared with oral administration of Western medication (MD=-2.08<0, 95%CI -3.09 to -1.06, P<0.0001). Conclusion: Tuina can produce more significant efficacy in treating primary insomnia compared with other traditional Chinese medicine therapies and oral administration of Western medication, especially the combination of head and back tuina.
作者机构：
[黄文豪] College of Acupuncture, Moxibustion and Tuina, Hunan University of CM, Changsha 410007, China;[娄必丹] Department of Acupuncture and Moxibustion, First Affiliated Hospital of Hunan University of CM, Changsha 410007
作者机构：
[谭静; 刘密; 刘迈兰; 马明珠; 邹逸凡; 石佳; 阳晶晶; 常小荣] College of Acu-moxibustion and Massage, Hunan University of Chinese Medicine, Changsha 410208, China;[赵钊] Department of Acu-moxibustion and Tuina and Rehabilitation, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007
作者机构：
[Liang, Ri-xin; Li, Qiu-yue; Guo, Qiu-yan; Zhang, Yi; Li, De-feng; Zhang, Yan-qiong; Tang, Shi-huan; Yang, Hong-jun; Xu, Hai-yu] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.;[Ren, Wei-qiong] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Changsha 410007, Hunan, Peoples R China.;[Wang, Song-song] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China.
通讯机构：
[Xu, Hai-yu] C;China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
关键词：
traditional Chinese medicine;Guanxinjing capsule;coronary heart disease;depression;integrative pharmacology;in silico ADME prediction;target prediction;network analysis
摘要：
Guanxinjing capsules (GXJCs) are used in traditional Chinese medicine as a common therapy for coronary heart disease (CHD) complicated with depression. In this study, we aimed to identify the main active constituents in GXJCs and to investigate the mechanisms of GXJC action on CHD complicated with depression. The chemical constituent profile of the GXJC was identified by UHPLC-LTQ-Orbitrap assay, and oral bioavailability was evaluated to screen the GXJC drug-like chemical constituents. A total of 16 GXJC drug-like chemical constituents were identified. Then, putative targets of the GXJC drug-like chemical constituents were predicted using MedChem Studio, with 870 genes found to be the putative targets of these molecules. After that, a GXJC putative target-known CHD/depression therapeutic target network was constructed, and four topological features, including degree, betweenness, closeness and K-coreness, were calculated. According to the topological feature values of the GXJC putative targets, 14 main active constituents were identified because their corresponding putative targets had topological importance in the GXJC putative target-known CHD/depression therapeutic target network, which were defined as the candidate targets of GXJC against CHD complicated with depression. Functionally, these candidate targets were significantly involved in several CHD/depression-related pathways, including repairing pathological vascular changes, reducing platelet aggregation and inflammation, and affecting patient depression. This study identified a list of main active constituents of GXJC acting on CHD complicated with depression using an integrative pharmacology-based approach that combined active chemical constituent identification, drug target prediction and network analysis. This method may offer an efficient way to understand the pharmacological mechanisms of traditional Chinese medicine prescriptions.
作者机构：
[高元峰; 欧阳荣; 刘昭前; 肖望重] Depl of Pharmacy, First Hospital of Hunan, University of Chinese Medicine, Changsha, 410007, China;[李珊] Depl of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China
作者机构：
[熊家青] Graduate School of Hunan University of Traditional Chinese Medicine, Changsha 410208, China;[刘丽芳; 李逵] Department of Breast Surgery, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, China;[张伟霞; 聂佳欣] Graduate School of Hunan University of Traditional Chinese Medicine, Changsha 410208
通讯机构：
Department of Breast Surgery, First Affiliated Hospital of Hunan University of Traditional, Chinese Medicine, Changsha, China
