The brain structure and function alterations in tension-type headache: A protocol for systematic review and meta analysis
作者:
Zhou, Jun;Cheng, Shirui;Yang, Han;Lan, Lei;Chen, Yijia;...
期刊:
MEDICINE ,2020年99(24):e20411 ISSN:1357-3039
通讯作者:
Li, ZJ;Liu, ML
作者机构:
[Zhou, Jun; Lan, Lei; Li, Zhengjie; Yang, Han; Yin, Zihan; Xu, Guixing; Li, ZJ; Cheng, Shirui] Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Coll, Chengdu, Sichuan, Peoples R China.;[Liu, Mailan] Hunan Univ Chinese Med, Coll Acupuncture & Moxibust & Tuina, Changsha, Hunan, Peoples R China.;[Chen, Yijia] Air Force Med Univ, Sch Basic Med, Xian, Peoples R China.;[Li, Zhengjie] Chengdu Univ Tradit Chinese Med, Acupuncture Brain Res Ctr, Chengdu, Sichuan, Peoples R China.
通讯机构:
[Li, ZJ ] C;[Liu, ML ] H;Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Coll, Chengdu, Sichuan, Peoples R China.;Hunan Univ Chinese Med, Coll Acupuncture & Moxibust & Tuina, Changsha, Hunan, Peoples R China.
关键词:
anisotropy;brain;brain mapping;checklist;devices;diagnostic imaging;female;human;male;meta analysis;metabolism;neuroimaging;pathophysiology;prevalence;procedures;tension headache;vascularization;visual analog scale;Anisotropy;Brain;Brain Mapping;Checklist;Female;Humans;Male;Neuroimaging;Outcome Assessment, Health Care;Prevalence;Tension-Type Headache;Visual Analog Scale
摘要:
Objective:The aim of this systematic review and meta-analysis is to improve the understanding of the pathophysiology of tension-type headache (TTH), as well as propose avenues for future neuroimaging studies of TTH.Methods:From the inception dates to May 1, 2020, a systematic literature will search in Medline (Ovid SP), Embase (Ovid SP), Cochrane Central Register of Controlled Trials, Web of Science, and 4 Chinese databases without limitation on language or publication. Additionally, International Clinical Trials Registry Platform, reference lists, and relevant gray literatures will be searched. After screening of eligible references, included studies will be determined according to included criteria, and then data extraction and a methodological quality assessment with a customized checklist will be conducted. Each process will be independently implemented by 2 reviewers, any disagreement will be resolved by consensus to the third researcher. If the extracted data is feasible, anisotropic effect-size version of signed differential mapping will be conducted to perform the meta-analysis of the structural and functional brain alterations in TTH patients. © 2020 Lippincott Williams and Wilkins. All rights reserved.
语种:
英文
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Cerebral fractional amplitude of low-frequency fluctuations may predict headache intensity improvement following acupuncture treatment in migraine patients
作者:
Li Zhengjie;Zhou Jun;Cheng Shirui;Lan Lei;Sun Ruirui;...
期刊:
中医杂志 ,2020年40(6):1041-1051 ISSN:1001-1668
通讯作者:
Zeng Fang;Liang, FR
作者机构:
[Liang Fanrong; Li Zhengjie; Gao Yujie; Zeng Fang; Zhou Jun; Cheng Shirui; Yang Jie; Lan Lei; Guo Taipin; Sun Ruirui] Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu 610000, Peoples R China.;[Liu Mailan] Hunan Univ Chinese Med, Acupuncture & Tuina Sch, Changsha 410000, Peoples R China.;[Gong Qi-yong] Sichuan Univ, West China Hosp, Huaxi Magnet Resonance Res Ctr, Chengdu 610000, Peoples R China.
通讯机构:
[Zeng, F; Liang, FR ] C;Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu 610000, Peoples R China.
关键词:
acupuncture;adult;amygdala;angular gyrus;Article;clinical outcome;controlled study;female;fractional amplitude of low-frequency fluctuation;functional magnetic resonance imaging;functional neuroimaging;hospital admission;human;major clinical study;male;middle frontal gyrus;middle temporal gyrus;migraine;nerve cell network;randomized controlled trial;rostral ventromedial medulla;superior temporal gyrus;thalamus;treatment response;young adult;brain;diagnostic imaging;headache;migraine;nuclear magnetic resonance imaging;treatment outcome;Acupuncture Therapy;Adult;Brain;Female;Headache;Humans;Magnetic Resonance Imaging;Male;Migraine Disorders;Treatment Outcome;Young Adult
摘要:
OBJECTIVE: To explore how baseline resting-state cerebral function predicts clinical outcomes of acupuncture treatment for migraine. METHODS: One hundred migraine patients and 46 healthy subjects were recruited. Patients were randomized into the acupuncture, sham acupuncture, and waiting list groups. Resting-state functional magnetic resonance imaging data were collected at baseline and after 1 month of longitudinal acupuncture treatments. Fractional amplitude of low-frequency fluctuations (fALFF) calculations were applied to explore the associations between baseline fALFF and changes in clinical variables in the acupuncture treatment group and the waiting list group. RESULTS: Compared with healthy subjects, migraine patients had lower fALFF in the left rostral ventromedial medulla, right thalamus, left amygdala, and right angular gyrus. Regression analyses revealed that baseline fALFF values in the left middle frontal gyrus, left superior temporal gyrus, and middle temporal gyrus were positively associated with headache intensity changes in the acupuncture treatment group, while baseline fALFF values in the bilateral lingual gyrus and cuneus were negatively associated with headache intensity changes in this group. CONCLUSION: The baseline fALFF values of brain regions associated with cognitive pain modulation, but not migraine severity, may predict future headache intensity improvement levels in migraine patients receiving acupuncture treatment. © 2020 JTCM. All rights reserved.
语种:
英文
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从阿是穴与穴位敏化的关系探讨针灸治病选穴原则
作者:
胡明岸;刘迈兰;黄河;常小荣
期刊:
中华中医药杂志 ,2020年35(11):5477-5479 ISSN:1673-1727
作者机构:
[常小荣; 黄河; 胡明岸; 刘迈兰] 湖南中医药大学
关键词:
针灸;阿是穴;穴位敏化;选穴原则
摘要:
在临床实践过程中,常应用"阿是之法"来治疗疾病,其形成和发展有着悠久的历史渊源,而穴位敏化是近些年新兴的概念,既有传统中医理论的解释亦有现代科学方面的研究。对于阿是穴与穴位敏化的关系,它们有理论的一致性,同时,穴位敏化理论更是阿是穴理论的继承和发展。在临床应用方面,综合运用传统针灸取穴、阿是穴、穴位敏化理论能够取得更好的临床疗效,文章就阿是穴与穴位敏化的关系来探讨针灸治病选穴原则,以使其理论更好地运用于临床。
语种:
中文
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An fMRI-based neural marker for migraine without aura
作者:
Tu, Yiheng;Zeng, Fang;Lan, Lei;Li, Zhengjie;Maleki, Nasim;...
期刊:
NEUROLOGY ,2020年94(7):E741-E751 ISSN:0028-3878
通讯作者:
Kong, J;Liang, FR
作者机构:
[Kong, Jian; Tu, Yiheng; Maleki, Nasim; Lang, Courtney; Park, Joel] Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA 02129 USA.;[Kong, Jian; Tu, Yiheng; Maleki, Nasim; Lang, Courtney; Park, Joel] Harvard Med Sch, Charlestown, MA 02129 USA.;[Zeng, Fang; Lan, Lei; Liang, Fanrong; Li, Zhengjie] Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China.;[Chen, Jun; Liu, Bo] Guangdong Prov Hosp Chinese Med, Dept Radiol, Guangzhou, Peoples R China.;[Wang, Chenchen] Tufts Med Ctr, Ctr Complementary & Integrat Med, Div Rheumatol, Boston, MA 02111 USA.
通讯机构:
[Kong, J ] M;[Liang, FR ] C;Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA 02129 USA.;Harvard Med Sch, Charlestown, MA 02129 USA.;Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China.
摘要:
OBJECTIVE: To identify and validate an fMRI-based neural marker for migraine without aura (MwoA) and to examine its association with treatment response. METHODS: We conducted cross-sectional studies with resting-state fMRI data from 230 participants and machine learning analyses. In studies 1 through 3, we identified, cross-validated, independently validated, and cross-sectionally validated an fMRI-based neural marker for MwoA. In study 4, we assessed the relationship between the neural marker and treatment responses in migraineurs who received a 4-week real or sham acupuncture treatment, or were waitlisted, in a registered clinical trial. RESULTS: In study 1 (n = 116), we identified a neural marker with abnormal functional connectivity within the visual, default mode, sensorimotor, and frontal-parietal networks that could discriminate migraineurs from healthy controls (HCs) with 93% sensitivity and 89% specificity. In study 2 (n = 38), we investigated the generalizability of the marker by applying it to an independent cohort of migraineurs and HCs and achieved 84% sensitivity and specificity. In study 3 (n = 76), we verified the specificity of the marker with new datasets of migraineurs and patients with other chronic pain disorders (chronic low back pain and fibromyalgia) and demonstrated 78% sensitivity and 76% specificity for discriminating migraineurs from nonmigraineurs. In study 4 (n = 116), we found that the changes in the marker responses showed significant correlation with the changes in headache frequency in response to real acupuncture. CONCLUSION: We identified an fMRI-based neural marker that captures distinct characteristics of MwoA and can link disease pattern changes to brain changes.
语种:
英文
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针刺、艾灸对功能性消化不良大鼠胃、肠ICC超微结构和Cx43表达影响
作者:
胡舒宁;张国山;张彬彬;胡明岸;黄河;...
期刊:
辽宁中医药大学学报 ,2020年22(03):64-68 ISSN:1673-842X
作者机构:
[常小荣; 张彬彬; 张国山; 胡舒宁; 黄河; 胡明岸; 刘迈兰] 湖南中医药大学
关键词:
针刺;艾灸;功能性消化不良;Cajal间质细胞;缝隙连接蛋白43
摘要:
目的 对比针刺、艾灸对功能性消化不良(Functional Dyspepsia,FD)大鼠胃、肠Cajal间质细胞(Interstitial Cells of Cajal,ICC)超微结构和缝隙连接蛋白43(Connexin 43,Cx43)表达的影响.方法 SD大鼠随机分成正常组、模型组、电针组及艾灸组,除了正常组的其他3组建立FD大鼠模型,电针组和艾灸组各予以电针、艾灸干预足三里.采用透射电镜观察各组大鼠胃、肠ICC的超微结构,免疫组化法测定各组大鼠胃、肠Cx43的表达.结果 模型组与正常组相比,大鼠胃、肠ICC的超微结构损伤,胞质内的细胞器较少,粗面内质网可见脱颗粒,跟周围细胞间的缝隙连接减少,胃、肠Cx43的表达显著降低(P<0.01或P<0.05);电针组、艾灸组与模型组相比,大鼠胃、肠ICC的超微结构显著改善,跟周围细胞间的缝隙连接显著增多,胃、肠Cx43的表达显著升高(P<0.01或P<0.05);电针组与艾灸组相互比较,大鼠胃、肠ICC的超微结构未见显著差别,胃、肠Cx43的表达无显著性差异(P>0.05).结论 针刺与艾灸足三里均可修复FD大鼠胃、肠ICC的超微结构,增加其Cx43的表达,且两者作用效果无明显优异性差别.
语种:
中文
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Effect of Tai Chi Chuan in Breast Cancer Patients: A Systematic Review and Meta-Analysis
作者:
Luo, Xiao-Chao;Liu, Jie;Fu, Jia;Yin, Hai-Yan;Shen, Li;...
期刊:
FRONTIERS IN ONCOLOGY ,2020年10:506578 ISSN:2234-943X
通讯作者:
Tang, Y
作者机构:
[Lan, Lei; Tang, Yong; Luo, Xiao-Chao; Shen, Li; Yin, Hai-Yan] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.;[Liu, Jie] Sichuan Prov Peoples Hosp, Chengdu, Peoples R China.;[Tang, Yong; Fu, Jia] Chengdu Univ, Med & Nursing Sch, Chengdu, Peoples R China.;[Liu, Mai-Lan] Hunan Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Changsha, Peoples R China.;[Lan, Lei; Tang, Yong] Key Lab Sichuan Prov Acupuncture & Chronobiol, Chengdu, Peoples R China.
通讯机构:
[Tang, Y ] C;Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.;Chengdu Univ, Med & Nursing Sch, Chengdu, Peoples R China.;Key Lab Sichuan Prov Acupuncture & Chronobiol, Chengdu, Peoples R China.
关键词:
Tai Chi Chuan;breast cancer;Quality of Life;Meta-analysis;Physical and psychological symptoms
摘要:
Background: Tai Chi Chuan(TCC), as a mind-body exercise, may have a positive impact on physical function and psychological well-being in breast cancer patients. The latest systematic review and meta-analysis of TCC for breast cancer was made 4 years ago and some new clinical trials about it were published. We remade a systematic review and meta-analysis to evaluate the effect of TCC in breast cancer patients. Methods: In this systematic review and meta-analysis, we searched MEDLINE (via PubMed), EMBASE (via embase.com), CENTRAL, CNKI, COVIP, Wanfang, Chaoxing, CiNii, J-SSTAGE, DBpia, and ThaiJO with no language restrictions from inception to December 31, 2018 (updated on February 16, 2020), for randomized clinical trials comparing TCC with non-exercised therapy in breast cancer patients. The primary outcome was quality of life in patients with breast cancer and data pooled by a rando meffects model. Subgroup analyses were conducted to estimate the effect of different durations of TCC for breast cancer patients. This study was registered in PROSPERO, number CRD 4201810326. Results: Fifteen articles involving a total of 885 breast cancer participants were included in this review. Compared with non-exercised therapy, TCC had a significant effect on quality of life in breast cancer patients (SMD = 0.37, 95% CI 0.15–0.59, p = 0.001), and subgroup analysis found that TCC showed beneficial effect in 12 weeks and 25 weeks (12 weeks: SMD = 0.40, 95% CI 0.19–0.62, p = 0.0003; 25 weeks: SMD = 0.38, 95% CI 0.15–0.62, p = 0.002). Meta-analyses of secondary outcomes showed that 3 weeks TCC increased shoulder function (SMD = 1.08, 95%CI 0.28–1.87, p = 0.008), 12 weeks TCC improved pain (SMD = 0.30, 95%CI 0.08–0.51, p= 0.007), shoulder function (SMD = 1.34, 95%CI 0.43–2.25, p = 0.004), strength of arm (SMD = 0.44, 95%CI 0.20–0.68, p = 0.0004), and anxiety (MD = −4.90, 95% CI −7.83 to −1.98, p = 0.001) in breast cancer patients compared with the control group. Conclusions: TCC appears to be effective on some physical and psychological symptoms and improves the quality of life in patients with breast cancer. Additional randomized controlled trials with a rigorous methodology and low risk of bias are needed to provide more reliable evidence. © 2020 Luo, Liu, Fu, Yin, Shen, Liu, Lan, Ying, Qiao, Tang and Tang.
语种:
英文
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循经辨证取穴针刺治疗功能性消化不良:随机对照试验
作者:
刘红华;张国山;刘惠娟;李朵朵;刘密;...
期刊:
针灸推拿医学:英文版 ,2020年18(5):352-358 ISSN:1672-3597
通讯作者:
Xiao-rong Chang<&wdkj&>Mai-lan Liu
作者机构:
[刘红华; 张国山; 刘惠娟; 李朵朵; 刘密; 常小荣; 刘迈兰] Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构:
[Xiao-rong Chang; Mai-lan Liu] H;Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Hunan University of Chinese Medicine, Changsha, China
关键词:
Acupuncture Therapy;Point Selection, Meridian;Point Selection Based on Syndrome Differentiation;Dyspepsia;Randomized Controlled Trial
摘要:
Objective: To observe the difference in clinical efficacy between acupuncture with point selection based on syndrome differentiation along the meridians and acupuncture at non-meridian and non-acupoint points for functional dyspepsia (FD). Methods: A total of 74 FD patients were randomized into an observation group and a control group, with 37 cases in each group. Both groups received acupuncture treatment. Zusanli (ST 36) and Neiguan (PC 6) were selected in the observation group, with Taichong (LR 3) and Neiting (ST 44) added for excess syndrome, and Gongsun (SP 4) and Yinlingquan (SP 9) added for deficiency syndrome. Four non-meridian and non-acupoint points were selected in the control group. The treatments in both groups were performed once a day with a 2-day break after 5 consecutive treatments, which constituted one treatment course. A total of 4 courses were performed. The scores of Nepean dyspepsia index (NDI) and Leeds dyspepsia questionnaire (LDQ) were recorded before and after treatment, and during follow-up (8, 12, 16, 20 and 24 weeks after recruitment) to assess the clinical efficacy. Results: The NDI scores in the two groups after treatment and at each time point during follow-up were higher than those before treatment (all P<0.05), and the LDQ scores were lower than those before treatment (all P<0.05). The NDI scores after treatment and at each time point during follow-up in the observation group were higher than those in the control group (all P<0.01); the total LDQ score and scores of upper abdominal pain, postprandial satiety and upper abdominal burning sensation after treatment and at each time point during follow-up in the observation group were significantly lower than those in the control group (P<0.01 or P<0.05). Conclusion: Acupuncture with point selection based on syndrome differentiation along the meridians has a better curative effect than acupuncture at non meridian and non-acupoint points in the treatment of FD. © 2020, Shanghai Research Institute of Acupuncture and Meridian.
语种:
英文
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浅析三伏灸的理论基础与临床运用
作者:
刘红华;欧阳里知;葛君芸;刘琼;胡辉;...
期刊:
中国针灸 ,2020年40(7):745-748 ISSN:0255-2930
作者机构:
[刘红华] Nursing School, Hunan University of CM, Changsha 410208, China;[葛君芸; 刘迈兰; 欧阳里知; 刘琼; 常小荣] School of Acupuncture-Moxibustion and Tuina, Hunan University of CM, Changsha 410208, China;[胡辉] First Affiliated Hospital of Hunan University of CM
关键词:
三伏灸;冬病夏治;干预时机;适应证;疗程
摘要:
对三伏灸临床应用现状进行归纳总结,以期对三伏灸的理论研究与临床运用起指导作用。三伏灸的干预时机以头、中、末伏第1天为主,同时需兼顾地域因素的影响;适应证以肺系疾病最为多见,兼顾脾胃以及虚寒型病症;选穴以胸背部俞募穴为主,结合辨病、辨证、分期选穴;疗程为1~3年,临床疗效随着治疗年限增加而不断提高。
语种:
中文
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姜京明教授闪火灸法结合针刺治疗带状疱疹经验
作者:
胡明岸;刘迈兰;孙永康;常小荣
期刊:
中医研究 ,2020年33(5):48-50 ISSN:1001-6910
作者机构:
[常小荣; 胡明岸; 刘迈兰] 湖南中医药大学;[孙永康] 河南中医药大学
关键词:
带状疱疹;闪火灸法;针刺;经验;姜京明;中医师
摘要:
姜京明教授师承家父,传承家族针灸技术,在针灸科常见病、多发病的诊治方面有着丰富的临床经验,并在近40年临床实践的基础上形成了具有个人特色的治疗方法。姜教授擅长运用针灸治疗重症肌无力、耳鸣、耳聋、带状疱疹、面神经炎、中风、哮喘等疾病,先后参与国家级、省市级课题8项,在国家级刊物发表论文10余篇。姜教授经过多年的临床经验与系统总结,在带状疱疹的针灸治疗上有着独特有效的治疗方法,其具有特色的闪火灸法结合针刺治疗带状疱疹在临床上取得了良好的疗效。通过闪火灸法、围刺法及抗病毒治疗的联合运用,使得带状疱疹的病程得到了缩短,同时在缓解疼痛症状上具有明显优势。现将姜京明教授治疗带状疱疹的临床经验作如下总结。
语种:
中文
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毫针补泻手法与中国古代哲学思维的关系探讨
作者:
胡明岸;刘迈兰;肖山峰;常小荣
期刊:
中国中医药现代远程教育 ,2020年18(2):39-41 ISSN:1672-2779
作者机构:
湖南中医药大学针灸推拿学院,湖南长沙410007;[常小荣; 肖山峰; 胡明岸; 刘迈兰] 湖南中医药大学
关键词:
中国古代哲学;针刺疗法;毫针补泻手法
摘要:
中国朴素唯物主义自然观以《周易》为源头,是古人对天人关系、自然的本原以及演化的基本观点,具有鲜明的中国传统特色,在天人关系上,崇尚以“天人合一”为主导,以一个整体看待人与自然的内在关系,人即为自然,并且参与自然的演化。中医是中国的传统医学,中医基本理论是以古人对自然界的认识的基础上发展而来的。中医领域一个重要的分支——针灸学,其指导理论亦应与中国朴素唯物主义自然观息息相关,在毫针补泄手法上亦可窥见一二。本文主要探讨了部分毫针补泻手法的形成、演化与中国古代哲学的内在联系,以更好地使理论指导临床。
语种:
中文
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The Spontaneous Activity Pattern of the Middle Occipital Gyrus Predicts the Clinical Efficacy of Acupuncture Treatment for Migraine Without Aura
作者:
Yin, Tao;Sun, Guojuan;Tian, Zilei;Liu, Mailan;Gao, Yujie;...
期刊:
FRONTIERS IN NEUROLOGY ,2020年11:588207 ISSN:1664-2295
通讯作者:
Liang, Fanrong;Zeng, Fang;Lan, L;Zeng, F
作者机构:
[Liang, Fanrong; Zeng, Fang; Lan, L; Lan, Lei; Li, Zhengjie; Tian, Zilei; Zeng, F; Yin, Tao] Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu, Peoples R China.;[Zeng, Fang; Lan, L; Lan, Lei; Li, Zhengjie; Tian, Zilei; Zeng, F; Yin, Tao] Chengdu Univ Tradit Chinese Med, Acupuncture & Brain Sci Res Ctr, Chengdu, Peoples R China.;[Sun, Guojuan] Hosp Chengdu Univ Tradit Chinese Med, Dept Gynecol, Chengdu, Peoples R China.;[Liu, Mailan] Hunan Univ Chinese Med, Coll Acupuncture & Moxibust & Tui Na, Changsha, Peoples R China.;[Gao, Yujie] Ningxia Med Univ, Tradit Chinese Med Sch, Yinchuan, Ningxia, Peoples R China.
通讯机构:
[Liang, FR; Lan, L ; Zeng, F] C;[Zeng, F ] K;Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu, Peoples R China.;Chengdu Univ Tradit Chinese Med, Acupuncture & Brain Sci Res Ctr, Chengdu, Peoples R China.;Key Lab Sichuan Prov Acupuncture & Chronobiol, Chengdu, Peoples R China.
关键词:
Migraine without Aura;Acupuncture;multivariate pattern analysis;machine learning;Amplitude of low-frequency fluctuation;efficacy prediction
摘要:
The purpose of the present study was to explore whether and to what extent the neuroimaging markers could predict the relief of the symptoms of patients with migraine without aura (MWoA) following a 4-week acupuncture treatment period. In study 1, the advanced multivariate pattern analysis was applied to perform a classification analysis between 40 patients with MWoA and 40 healthy subjects (HS) based on the z-transformed amplitude of low-frequency fluctuation (zALFF) maps. In study 2, the meaningful classifying features were selected as predicting features and the support vector regression models were constructed to predict the clinical efficacy of acupuncture in reducing the frequency of migraine attacks and headache intensity in 40 patients with MWoA. In study 3, a region of interest–based comparison between the pre- and post-treatment zALFF maps was conducted in 33 patients with MwoA to assess the changes in predicting features after acupuncture intervention. The zALFF value of the foci in the bilateral middle occipital gyrus, right fusiform gyrus, left insula, and left superior cerebellum could discriminate patients with MWoA from HS with higher than 70% accuracy. The zALFF value of the clusters in the right and left middle occipital gyrus could effectively predict the relief of headache intensity (R2 = 0.38 ± 0.059, mean squared error = 2.626 ± 0.325) and frequency of migraine attacks (R2 = 0.284 ± 0.072, mean squared error = 20.535 ± 2.701) after the 4-week acupuncture treatment period. Moreover, the zALFF values of these two clusters were both significantly reduced after treatment. The present study demonstrated the feasibility and validity of applying machine learning technologies and individual cerebral spontaneous activity patterns to predict acupuncture treatment outcomes in patients with MWoA. The data provided a quantitative benchmark for selecting acupuncture for MWoA. © Copyright © 2020 Yin, Sun, Tian, Liu, Gao, Dong, Wu, Li, Liang, Zeng and Lan.
语种:
英文
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基于代谢组学的针灸作用机制研究进展
作者:
钟欢;邵湘宁;胡舒宁;佘畅;刘霞;...
期刊:
世界中医药 ,2019年14(3):542-547 ISSN:1673-7202
作者机构:
湖南中医药大学针灸推拿学院;[谭晓文] 湘西土家族苗族自治州民族中医院;[刘密] 浏阳市中医医院;[邵湘宁; 常小荣; 胡舒宁; 钟欢; 刘迈兰; 佘畅; 刘霞] 湖南中医药大学
关键词:
针灸;代谢组学;作用机制;神经递质;能量代谢;氨基酸;综述
摘要:
代谢组学是新近兴起的一种系统生物学研究手段,具有整体性、动态性反应生物体接受刺激时所作出的代谢物层面的变化,与中医整体观十分吻合,因此广泛用于中医中药学的研究中,在针灸学机制的研究中早已将代谢组学作为一种有效的研究手段,近年来针灸代谢组学的研究日趋增多,在揭示针灸作用机制方面也取得了一定的成果,故对现今的研究做一综述,以愿能为代谢组学广泛应用于针灸的现代化研究提供新思路。
语种:
中文
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基于微信公众号的翻转课堂教学模式在中医养生学课程教学中的探索
作者:
唐雨兰;刘迈兰;杨茜芸;郁洁;李南;...
期刊:
中国中医药现代远程教育 ,2019年17(20):15-17 ISSN:1672-2779
作者机构:
湖南中医药大学针灸推拿学院,湖南长沙,410007;[唐雨兰; 郁洁; 杨茜芸; 宋家薇; 李南; 刘迈兰] 湖南中医药大学
关键词:
微信公众号;翻转课堂;中医养生学;教学模式
摘要:
目的 介绍将基于微信公众号的“翻转课堂”教学模式运用到《中医养生学》课程实践教学.方法 将微信公众号作为翻转课堂教学模式实施的载体,将整个教学过程分成“在线课程学习”“教师课堂讲授”和“线上的互动课堂”3个环节来进行,然后采用阶段性、形成性评价,客观考试成绩与主观感受问卷调查相结合方式,对最终的教学实践结果予以评估.结果 发现学生的综合成绩、论文整体水平、学习能力提升,学习兴趣与积极性增强.结论 基于微信公总号的“翻转课堂”教学模式适合在《中医养生学》课程中开展,可考虑此种教学模式在全校其他课程推广.
语种:
中文
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隔药饼灸对动脉粥样硬化兔血管内皮修复与基质细胞衍生因子1的影响
作者:
沈菁;刘涛;刘霞;葛君芸;汪厚莲;...
期刊:
中国针灸 ,2019年39(2):173-8 ISSN:0255-2930
作者机构:
[葛君芸; 刘迈兰; 沈菁; 刘涛; 刘霞; 常小荣] College of Acupuncture-Moxibustion and Tuina, Hunan University of CM, Changsha 410208, China;[汪厚莲] Hunan Junior College of TCM;[Guo, An-Lin] Changsha Civil Vocational Technical School
关键词:
动脉粥样硬化;隔药饼灸;总胆固醇;三酰甘油;低密度脂蛋白胆固醇;高密度脂蛋白胆固醇;基质细胞衍生因子1
摘要:
目的:观察隔药饼灸对动脉粥样硬化兔受损血管内皮结构的修复以及基质细胞衍生因子1(stromal cells derived factor 1,SDF-1)含量的影响。方法:将75只兔随机分为正常组、模型组、直接灸组、阿托伐他汀钙组与隔药饼灸组,每组15只,正常组采用普通饲料喂养,其余各组采用高胆固醇饲养法喂养12周制备动脉粥样硬化兔模型。隔药饼灸组与直接灸组选取两组穴位:“巨阙”“天枢”“丰隆”穴;“心俞”“肝俞”“脾俞”穴。每组穴隔日交替施灸,每穴灸30 min,每日1次,连续4周。阿托伐他汀钙组每天将阿托伐他汀钙片(1.96 mg·kg~(-1)·d~(-1))碾成粉末后拌入第1餐饲料中喂食,造模后正常组、模型组不予上述干预处理,此3组同灸法时固定。以酶法测定总胆固醇(TC)、三酰甘油(TG)的含量;比色法测定低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的含量;光学显微镜下观察兔主动脉血管壁形态结构;酶联免疫吸附法测定血清SDF-1的含量。结果:干预后,与正常组比较,模型组TC、TG、LDL-C明显升高(均P<0.01),HDL-C明显降低(P<0.01);与模型组比较,直接灸组、阿托伐他汀钙组、隔药饼灸组TC、TG、LDL-C均明显降低(均P <0.01),HDL-C升高(P<0.01, P<0.05)。与正常组相比,模型组主动脉壁结构受损明显;与模型组相比,阿托伐他汀钙组、隔药饼灸组内皮结构有显著好转,直接灸组的主动脉内皮病理变化也有减轻。干预后,与模型组相比,直接灸组、阿托伐他汀钙组、隔药饼灸组血清中SDF-1水平有不同程度的升高(P<0.05,P<0.01),隔药饼灸组血清中SDF-1水平高于直接灸组(P <0.05)。结论:隔药饼灸能促进血清SDF-1的表达,修复受损血管内皮结构。
语种:
中文
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《针灸学》精品在线开放课程建设思路探究
作者:
许沁;刘迈兰;常小荣;钟欢;欧阳里知;...
期刊:
教育现代化 ,2019年(43):97-98 ISSN:2095-8420
作者机构:
1. 广州中医药大学针灸康复临床医学院;2. 湖南中医药大学针灸推拿学院
关键词:
针灸学;精品在线开放课程;课程建设
摘要:
《针灸学》是中医、中西结合等本科专业学生的必修课程。《针灸学》精品在线开放课程建设,能够提高学生综合素质,也有助于实现高校优质教学资源的共享和教学质量的提高。本文从《针灸学》精品在线开放课程建设的目的、内容和课程特色等方面进行探讨,希望能为精品在线课程的开展提供一定的帮助。
语种:
中文
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Abnormal thalamocortical network dynamics in migraine
作者:
Tu, Yiheng;Fu, Zening;Zeng, Fang;Maleki, Nasim;Lan, Lei;...
期刊:
NEUROLOGY ,2019年92(23):E2706-E2716 ISSN:0028-3878
通讯作者:
Kong, J;Liang, FR
作者机构:
[Kong, Jian; Tu, Yiheng; Maleki, Nasim; Wilson, Georgia; Park, Joel] Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA 02129 USA.;[Kong, Jian; Tu, Yiheng; Maleki, Nasim; Wilson, Georgia; Park, Joel] Harvard Med Sch, Charlestown, MA 02129 USA.;[Fu, Zening; Calhoun, Vince] Mind Res Network, Albuquerque, NM USA.;[Zeng, Fang; Lan, Lei; Liang, Fanrong; Li, Zhengjie] Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China.;[Gao, Yujie] Ningxia Med Univ, Tradit Chinese Med Sch, Yinchuan, Peoples R China.
通讯机构:
[Kong, J ] M;[Liang, FR ] C;Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA 02129 USA.;Harvard Med Sch, Charlestown, MA 02129 USA.;Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China.
摘要:
Objective: To investigate the dynamic functional connectivity of thalamocortical networks in interictal migraine patients and whether clinical features are associated with abnormal connectivity. Methods: We investigated dynamic functional network connectivity (dFNC) of the migraine brain in 89 interictal migraine patients and 70 healthy controls. We focused on the temporal properties of thalamocortical connectivity using sliding window cross-correlation, clustering state analysis, and graph-theory methods. Relationships between clinical symptoms and abnormal dFNC were evaluated using a multivariate linear regression model. Results: Five dFNC brain states were identified to characterize and compare dynamic functional connectivity patterns. We demonstrated that migraineurs spent more time in a strongly interconnected between-network state, but they spent less time in a sparsely connected state. Interestingly, we found that abnormal posterior thalamus (pulvinar nucleus) dFNC with the visual cortex and the precuneus were significantly correlated with headache frequency of migraine. Further topologic measures revealed that migraineurs had significantly lower efficiency of information transfer in both global and local dFNC. Conclusion: Our results demonstrated a transient pathologic state with atypical thalamocortical connectivity in migraineurs and extended current findings regarding abnormal thalamocortical networks and dysrhythmia in migraine. Glossary: AUC = area under the curve; AUD = auditory domain; CC = cognitive control domain; dFNC = dynamic functional network connectivity; DM = default mode domain; FC = functional connectivity; FDR = false discovery rate; GICA = group independent component analysis; HC = healthy controls; ICHD = International Classification of Headache Disorders; ICN = intrinsic component network; IRB = institutional review board; MIG = migraine without aura patients; MNI = Montreal Neurologic Institute; rsFC = resting-state functional connectivity; SAS = self-rating anxiety scale; SC = subcortical domain; SDS = self-rating depression scale; SM = sensorimotor domain; TCD = thalamocortical dysrhythmia; TE = echo time; TR = repetition time; VS = visual domain. © 2019 American Academy of Neurology.
语种:
英文
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雨课堂在《针灸学》教学中的应用前景浅析
作者:
张驰;刘涛;张国山;刘迈兰;常小荣
期刊:
湖南中医杂志 ,2019年35(02):101-103 ISSN:1003-7705
作者机构:
湖南中医药大学研究生院,湖南长沙,410208;湖南中医药大学针灸推拿学院,湖南长沙,410208;[常小荣; 张国山; 刘涛; 张驰; 刘迈兰] 湖南中医药大学
关键词:
《针灸学》;雨课堂;教学改革
摘要:
凝聚中华民族智慧和创造力的《针灸学》,已被纳入人类非物质文化遗产名录,逐渐成为世界认同的文化符号.目前《针灸学》教学发展受限于传统教学方式,很难与国际接轨,而基于网络的雨课堂教学模式蓬勃发展,颇受学生的欢迎.如何将针灸学与网络教学有机地结合起来,构建一种新理念、新途径、新模式教学的尝试与突破,以此调动学生学习的主动性和积极性,激发学生对该学科的学习热情和兴趣,提高教学效果,具有重要的现实意义.
语种:
中文
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基于雨课堂的针灸学混合式学习研究
作者:
张彬彬;胡舒宁;欧阳里知;刘密;钟欢;...
期刊:
教育现代化 ,2019年(43):138-139 ISSN:2095-8420
作者机构:
湖南中医药大学针灸推拿学院
关键词:
针灸学;雨课堂;混合模式
摘要:
《针灸学》作为高等中医院校中医专业的一门临床课程,是一门理论与实践相结合的学科,本文基于"雨课堂"的教学方法结合线下学习方案,对针灸学课程"课前—课中—课后"教学进行了研究与探讨。
语种:
中文
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隔药饼灸对动脉粥样硬化兔胆固醇逆转运核受体LXRα的调节作用
作者:
刘霞;刘迈兰;汪厚莲;呙安林;葛君芸;...
期刊:
针灸推拿医学:英文版 ,2019年17(1):1-8 ISSN:1672-3597
通讯作者:
Chang, XR;Shen, J
作者机构:
[刘霞; 刘迈兰; 葛君芸; 常小荣; 沈菁] School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, 410208, China;[汪厚莲] Hunan Traditional Chinese Medical College, Zhuzhou, 412012, China;[Guo A.-L.] Changsha Social Work College, Changsha, 410004, China
通讯机构:
[Xiao-rong Chang] S;School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, China
关键词:
Moxibustion Therapy;Indirect Moxibustion;Medicinal Cake-partitioned Moxibustion;Atherosclerosis;Cholesterol;Liver X Receptors;Rabbits
摘要:
Objective: To observe the effect of herbal cake-partitioned moxibustion on liver X receptor alpha (LXRα) in rabbits with atherosclerosis. Methods: Thirty-six male New Zealand rabbits were randomly divided into a normal group, a model group, a herbal cake-partitioned moxibustion group and a simvastatin group according to the random number table method, with 9 rabbits in each group. Rabbits in the model group, the herbal cake-partitioned moxibustion group and the simvastatin group were modeled by high fat feeding method which took 12 weeks. After verification of the successful model, rabbits in the normal group were not treated, in the model group were bundled, in the herbal cake-partitioned moxibustion group were treated with herbal cake-partitioned moxibustion, and those in the simvastatin group were treated with simvastatin, all for a total of 4 weeks. At the end of the experiment, the aorta and liver were observed for pathological changes; serum and liver were used to detect lipid levels; Western blot (WB) and real-time quantitative polymerase chain reaction (RT-qPCR) were used to detect LXRα protein and mRNA expression levels, respectively. Results: Compared with the normal group, the structure of aorta was disordered, the wall was rough and thick, the intima was unsmooth, and the vascular smooth muscle cells were arranged closely and disorderly in the model group, which was consistent with the characteristics of the rabbit model of aortic atherosclerosis. Compared with the model group, the aortic structure was clear, the degree of hepatocyte degeneration was reduced, the serum total cholesterol and low-density lipoprotein levels were significantly decreased (all P<0.01), the high-density lipoprotein level was elevated (P<0.01), and the total liver cholesterol was decreased significantly (P<0.01) in the rabbits of the herbal cake-partitioned moxibustion group and the simvastatin group; compared with the model group, the protein (P<0.01 or P<0.05) and mRNA (P<0.01) expressions of rabbit LXRα in the herbal cake-partitioned moxibustion group and the simvastatin group were increased. Conclusion: Herbal cake-partitioned moxibustion can improve the aortic and hepatic lesions, regulate blood lipid and liver lipid levels, increase the expression of liver cholesterol reverse transport nuclear receptor LXRα, promote reverse cholesterol transport in the rabbits with aortic atherosclerosis, therefore produces an antiatherogenic effect. © 2019, Shanghai Research Institute of Acupuncture and Meridian.
语种:
英文
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基于生物传热学的艾灸疗法物理学剂量研究
作者:
黄河;欧阳里知;胡明岸;肖山峰;张彬彬;...
期刊:
世界中医药 ,2019年14(3):521-526 ISSN:1673-7202
作者机构:
湖南中医药大学针灸推拿学院;[刘密] 浏阳市中医医院;[欧阳里知; 常小荣; 张彬彬; 贲定严; 胡舒宁; 肖山峰; 黄河; 胡明岸; 刘迈兰] 湖南中医药大学
关键词:
艾灸;灸法;疗法;灸量;生物传热学;物理学剂量
摘要:
目的:利用艾灸设备进行保健灸,建立正常人体艾灸的物理学剂量,为进一步研究患者艾灸剂量范围提供依据。方法:利用自制高精度温度传感器测定手足部、胸腹部及腰背部等穴位灸前瞬时温度,最高耐受瞬时温度,并记录产生最高耐受瞬时温度所需要的时间,通过自定义公式:穴位艾灸的物理学剂量=(灸前瞬时温度+最高耐受温度)/2×产生最高耐受温度所需要的时间,拟建立不同部位穴位的艾灸物理学剂量范围,并分析艾灸不同部位的物理学剂量范围差异。结果:手阴经的穴位艾灸时所需要的物理学剂量低于足阴经、胸腹部的穴位,手阳经的穴位艾灸时所需的物理学剂量低于足阳经、背腰部穴位,提示艾灸时手部经穴所需的物理学剂量低于足部及躯干部的穴位,说明手部穴位较之足部、躯干部穴位对光热更敏感。结论:不同部位的穴位均有一定的剂量范围,进行灸疗时,只要达到穴位的剂量范围,即可取得相应的效果。
语种:
中文
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