作者机构：
[朱建平; 袁志鹰] Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;TCM Diagnostic Institute, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;[张弋戈] Administration of Traditional Chinese Medicine of Hunan Province, Changsha, Hunan 410008, China;[张文安] Guangzhou Jiayibang Health Management Co., Ltd., Guangzhou, Guangdong 510000, China;[邓文祥; 李静; 吴华英; 姚中华] Hunan University of Chinese Medicine, Changsha, Hunan 410208, China<&wdkj&>TCM Diagnostic Institute, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
通讯机构：
[Zhang Wen-An] G;[Huang Hui-Yong] T;Guangzhou Jiayibang Health Management Co., Ltd., Guangzhou, Guangdong 510000, China<&wdkj&>TCM Diagnostic Institute, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China<&wdkj&>Administration of Traditional Chinese Medicine of Hunan Province, Changsha, Hunan 410008, China
摘要：
The utility model discloses a rhizoma polygonati drying device. Box body, a front cover is arranged on the front side of the box body; a plurality of fixed shafts are fixedly mounted on the rear wallin the box body; the fixed shaft horizontally extends along the length direction of the box body; the front end of the fixed shaft penetrates through the front cover; a linear bearing is mounted on the fixed shaft in a sliding manner; the front side of the linear bearing is connected with a clamping assembly; a plurality of heating pipes are arranged in the box body in the width direction; the beneficial effects of the utility model are that: the utility model discloses: the beneficial effect is: According to the utility model, polygonatum kingianum scales can be clamped by the clamping assembly; and the polygonatum kingianum is heated from the upper side and the lower side of the clamping assembly at the same time through the heating pipes, so that the surface heating range of the polygonatum kingianum is enlarged, the heating effect is improved, the drying speed of the polygonatum kingianum is increased, the polygonatum kingianum time is shortened, and the polygonatum kingianum efficiency is improved.
摘要：
ETHNOPHARMACOLOGICAL RELEVANCE: Buyang huanwu decoction (BYHWD) is a classic recipe in traditional Chinese medicine (TCM) to supplement Qi and activate blood. It has been used to recover the neural function after the injury of central nervous system for hundreds of years in China. AIM OF THE STUDY: This study investigated whether Buyang huanwu decoction (BYHWD) combined with bone marrow mesenchymal stem cells (BMSCs) transplantation had synergistic effect on neuroprotection of red nucleus neurons after spinal cord injury (SCI). MATERIALS AND METHODS: Rubrospinal tract (RST) transection model was established and BMSCs were collected. The forelimb locomotor function was recorded using inclined plate test and spontaneous vertical exploration. cAMP level in red nucleus was detected with Enzyme-linked immunosorbent assay (ELISA). Morphology and number of red nucleus neurons was observed using Nissl's staining. Expression of cAMP-response element binding protein (CREB), ras homolog gene family member A (RhoA) and nerve growth factor (NGF) in red nucleus was detected using immunohistochemistry, qRT-PCR and Western-blotting. RESULTS: The combination of BYHWD and BMSCs transplantation could improve the forelimb locomotor function significantly and give the red nucleus somas a better protection. Meanwhile, cAMP level, CREB and NGF increased, while RhoA decreased remarkably in the BYHWD+BMSCs group. CONCLUSIONS: BYHWD combined with BMSCs transplantation had synergistic effect on neuroprotection of red nucleus neurons after SCI; the mechanism may be related to up-regulating cAMP level, activating the cAMP/CREB/RhoA signaling pathway, and promoting expression of NGF.
作者机构：
[吴华英; 李静; 黄惠勇] Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;[张臣; Wang Zhao-Hua] Department of Cardiology, The Hunan Brain Hospital, Changsha, Hunan 410007, China;[李丰] Center for Oral/Head & Neck Oncology Research, School of Dentistry, University of California, Los Angeles, California 90095, USA;Department of Traditional Chinese Medicine, Luohu District People's Hospital, Shenzhen, Guangdong 518001, China;[张世鹰] Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China<&wdkj&>Department of Traditional Chinese Medicine, Luohu District People's Hospital, Shenzhen, Guangdong 518001, China
通讯机构：
[Huang Hui-Yong; Li Liang] P;Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China<&wdkj&>Center for Oral/Head & Neck Oncology Research, School of Dentistry, University of California, Los Angeles, California 90095, USA<&wdkj&>Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
摘要：
The main clinical manifestations of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis are acute or subacute seizures, cognition impairment, and psychiatric symptoms. Nowadays, the scheme of antipsychotic therapy for this disease has not been established. This study reports three cases of anti-NMDAR encephalitis with psychiatric symptoms. The anti-NMDAR antibodies in cerebrospinal fluid (CSF) and serum were positive. The psychiatric symptoms still existed after intravenous immunoglobulin (IVIG) treatment; thus, clozapine was used for antipsychotic therapy. Case 1 was a 37-year-old man who suffered from bad mood and suicide behaviors for 1 month. Hallucination and delusion still existed after IVIG treatment and hormone therapy, and the symptoms were relieved when given clozapine for 12 months. Case 2 was a 28-year-old man who was admitted to our hospital due to injuring other people and destructive behaviors for 2 days. He showed irritability, bad temper, declined cognition, and severe delusion of persecution after IVIG treatment and hormone therapy, but the psychiatric symptoms disappeared when given clozapine for 3 months. Case 3 was a 23-year-old man who suffered from headache and babbing for 7 days. Symptoms such as irritability, bad temper, babbing, and injuring other people still existed after IVIG treatment and hormone therapy, but they disappeared when given clozapine for 2 months. Therefore, we suggest that during the treatment of anti-NMDAR encephalitis with psychiatric symptoms, if the anti-NMDAR antibodies in CSF and serum were positive, and psychiatric symptoms could not be controlled after IVIG and hormone therapy, clozapine may work.
