Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia-reperfusion in rats
作者:
Yang, Ping;Tian, Ye-Mei;Deng, Wen-Xiang;Cai, Xiong;Liu, Wang-Hua;...
期刊:
Experimental and Therapeutic Medicine ,2019年18(4):2805-2812 ISSN:1792-0981
通讯作者:
Li, Liang;Huang, Hui-Yong
作者机构:
[Yang, Ping] Hunan Univ Chinese Med, Sch Clin Med, Brains Hosp Hunan Prov, Dept Psychiat, Changsha 410007, Hunan, Peoples R China.;[Cai, Xiong; Li, Liang; Huang, Hui-Yong; Tian, Ye-Mei; Liu, Wang-Hua; Deng, Wen-Xiang] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, 300 Xueshi Rd,Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.;[Li, Liang] Hunan Univ Chinese Med, Key Discipline Anat & Histoembryol, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Li, L; Huang, HY] H;Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, 300 Xueshi Rd,Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.
关键词:
Sijunzi decoction;apoptosis;cerebral ischaemia-reperfusion;collagen IV;extracellular matrix;matrix metalloproteinase 9;tissue inhibitor of metalloproteinase 1
摘要:
Neurons undergo degeneration, apoptosis and death due to ischaemic stroke. The present study investigated the effect of Sijunzi decoction (SJZD), a type of traditional Chinese medicine known as invigorating spleen therapy, on anoikis (a type of apoptosis) in rat brains following cerebral ischaemia-reperfusion. Rats were randomly divided into sham, model, nimodipine and SJZD low/medium/high dose groups. A middle cerebral artery occlusion model was established. Neurobehavioural scores were evaluated after administration for 14 days using a five-grade scale. Blood-brain barrier permeability and apoptotic rate were detected using Evans blue (EB) extravasation and TUNEL staining, respectively. Tissue inhibitor of metalloproteinase 1 (TIMP-1), matrix metalloproteinase 9 (MMP-9) and collagen IV (COL IV) were determined using immunohistochemistry. Neurobehavioural scores decreased remarkably in all SJZD and nimodipine groups compared to the model group (P<0.05). Compared with the sham group, EB extravasation was higher in the model group (P<0.01). The amount of EB extravasation decreased in the SJZD high dose and nimodipine groups compared to the model group (P<0.01), and extravasation in the SJZD high dose group was lower than the SJZD low and medium dose groups (P<0.01). TIMP-1 and MMP-9 expression and apoptotic rate increased, but COL IV decreased significantly in the hippocampus of the model group compared to the sham group (P<0.01). TIMP-1 and COL IV expression increased significantly and MMP-9 and apoptotic rate decreased remarkably in all SJZD and nimodipine groups compared to the model group (P<0.01). TIMP-1 and COL IV expression decreased, but MMP-9 expression and apoptotic rate increased in the SJZD low and medium dose groups compared to the SJZD high dose group (P<0.01). SJZD rescued neurons and improved neurobehavioural function in rats following cerebral ischaemia-reperfusion, especially when used at a high dose. The mechanism may be related to protection of the extracellular matrix followed by anti-apoptotic effects.
语种:
英文
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Establishment and Evaluation of a Rat Model of Spinal Cord Injury with the Pathopattern of Qi-Deficiency and Blood-Stasis in Traditional Chinese Medicine
作者:
李亮;李丰;殷坚;潘波;余清平;...
期刊:
数字中医药(英文) ,2018年1(1):102-112 ISSN:2096-479X
通讯作者:
Huang, H.-Y.
作者机构:
[黄惠勇; 蔡雄] Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;[余清平; 潘波; 陈安; 殷坚] Key Discipline of Anatomy and Histoembryology, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;School of Dentistry, University of California Los Angeles, California, CA 9005, United States;[李丰] Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, School of Dentistry, University of California Los Angeles, California, CA 9005, United States;[李亮] Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, Key Discipline of Anatomy and Histoembryology, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
通讯机构:
[Huang, H.-Y.] P;Provincial Key Laboratory of TCM Diagnostics, China
关键词:
脊髓损伤;气虚血瘀;补阳还五汤;红核脊髓束
摘要:
目的制备脊髓损伤(SCI)气虚血瘀证大鼠模型,评价该模型的合理性。方法采用游泳力竭法联合红核脊髓束(RST)横断手术制备SCI气虚血瘀证大鼠模型,通过观察中医宏观表征、肢体行为学、血液流变学及脊髓组织形态,结合益气活血中药复方补阳还五汤(BYHWD)进行反证,最终评价该模型的合理性。结果气虚血瘀组大鼠体重、摄食量和前肢使用率降低,舌象评分上升,符合气虚血瘀证的表现;35 d后BYHWD组各指标均优于气虚血瘀组。与正常组相比,气虚血瘀组全血黏度、红细胞压积上升(P <0.05),红细胞变形指数下降(P <0.05);BYHWD组经过中药干预后各指标基本接近正常组。脊髓受损局部出现隆起、硬结,疑似空泡或瘢痕,HE染色显示大鼠脊髓冠状切片伤侧面积比率BYHWD组高于气虚血瘀组(P <0.05)。结论游泳力竭法联合RST横断术能顺利制备SCI气虚血瘀证大鼠模型。
语种:
中文
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固肺消积饮治疗非小细胞肺癌作用机制的网络药理学分析
作者:
贺佐梅;曾普华;郜文辉;徐云;黄惠勇
期刊:
中医杂志 ,2018年59(13):1139-1143 ISSN:1001-1668
作者机构:
湖南中医药大学研究生院, 湖南, 长沙, 410208;湖南省中医药研究院附属医院;湖南中医药大学中医学院;湖南省湘潭市第一人民医院;[贺佐梅] 湖南中医药大学研究生院, 湖南, 长沙, 410208
关键词:
非小细胞肺癌;固肺消积饮;药物靶点;基因富集分析;网络药理学
摘要:
目的基于网络药理学方法探讨固肺消积饮治疗非小细胞肺癌的可能作用机制。方法利用TCMSP数据库,采用口服生物利用度筛选和药物相似性评价筛选固肺消积饮药物有效成分,并预测疾病靶点,构建成分靶点网络图,并筛选核心网络图,用DAVID数据库进行基因富集分析,获得GO功能注释结果及KEGG通路分析注释结果,并在KEGG通路分析中获得参与相关通路的候选基因及功能。结果从TCMSP数据库筛选出固肺消积饮的149种活性成分,与肺癌相关的246个潜在靶标;成分靶点网络图显示1502个成分靶点相互作用,以其中相关程度值大于8的53种成分构建核心网络图;基因富集分析提示,42个靶点参与多条通路,其中大量靶点与PI3K-AKT通路及Ca~(2+)信号通路调控有关。结论固肺消积饮可能通过调控PI3K-AKT通路及Ca~(2+)信号通路而达到延缓非小细胞肺癌化疗耐药、降低化疗毒副作用、增加化疗敏感性的效果。
语种:
中文
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数字中医药在中医药发展中的前景展望
作者:
夏帅帅;李亮;杨萍;邵峰;孙贵香;...
期刊:
中华中医药杂志 ,2018年33(12):5298-5300 ISSN:1673-1727
作者机构:
湖南中医药大学,长沙410208;湖南中医药大学数字中医药协同创新中心,长沙410208;湖南省第二人民医院,长沙410007;[夏帅帅; 李亮; 邵峰; 孙贵香; 黄惠勇] 湖南中医药大学, 长沙, 410208 湖南中医药大学, 数字中医药协同创新中心, 长沙, 410208;[杨萍] 湖南中医药大学, 长沙, 410208 湖南省第二人民医院, 长沙, 410007
关键词:
中医;数字中医药;发展
摘要:
近代以来,随着农业社会向工业社会转换,中医药开始停滞不前,凸显落后,中医药人却无法找到其发展的突破点。笔者立足发展的角度,从时代发展、学科融合创新、大数据驱动及产业与时俱进4个方面的要求探讨数字中医药研究在中医药发展上的紧迫性、重要性。
语种:
中文
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行业特色型高校产学研对办学质量提高的影响研究——以湖南中医药大学为例
作者:
湛欢;廖菁;黄惠勇
期刊:
医学食疗与健康 ,2018年(4):160-160 ISSN:2096-5249
作者机构:
[黄惠勇; 廖菁; 湛欢] 湖南中医药大学
关键词:
行业特色型;产学研;办学质量
摘要:
行业特色型高校是所在行业发展的领头羊,同时也是我国高等教育体系的重要组成部分,如何将“产学研”与“办学质量”有机结合,是行业特色型高校完成其使命的重要途径.本文以湖南中医药大学为例,建立回归模型,得到了一些正确处理“产学研”与“办学质量”相互关系的启示.
语种:
中文
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莲的化学成分及药理研究进展
期刊:
亚太传统医药 ,2018年14(11):73-76 ISSN:1673-2197
作者机构:
[谢梦洲; 黄惠勇; 袁志鹰] 湖南中医药大学;湖南省中药饮片标准化及功能工程技术研究中心;湖南省药食同源功能性食品工程技术中心
关键词:
莲;化学成分;药理活性
摘要:
莲是药食两用药材的大品种,包括莲须、莲房、莲子、莲子心、藕节和荷叶等多个药用部位,主要分布于湖南、江西、福建和湖北等地。通过大量文献调研,综述莲的主要化学成分,包括荷叶碱、莲心碱、莲子多糖和原花青素等化合物。莲还具有广泛的药理作用,如降脂减肥、改善睡眠和润肠通便等功效,具有巨大的研究和开发潜力。对莲的化学成分及药理作用进行文献总结,以期为其深入研究与开发提供参考。
语种:
中文
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Transanal hemorrhoidal dearterialization versus stapled hemorrhoidectomy in the treatment of hemorrhoids A PRISMA-compliant updated meta-analysis of randomized control trials
作者:
Song, Yan;Chen, Honglei;Yang, Fang;Zeng, Yuheng;He, Yongheng* ;...
期刊:
Medicine ,2018年97(29):e11502 ISSN:0025-7974
通讯作者:
He, Yongheng;Huang, Huiyong
作者机构:
[Song, Yan; Yang, Fang; Zeng, Yuheng; He, Yongheng] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Colonproctol Surg, 233 Cai E Bei Rd, Changsha 410005, Hunan, Peoples R China.;[Song, Yan; Huang, Huiyong] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost & Therapeut Res Chine, 300 Xueshi Rd,Hanpu Sci & Educ Ind Pk, Changsha 410208, Hunan, Peoples R China.;[Chen, Honglei] Sun Yat Sen Univ, Dept Gastrointestinal Endoscopy, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou, Guangdong, Peoples R China.
通讯机构:
[He, Yongheng; Huang, Huiyong] H;Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Colonproctol Surg, 233 Cai E Bei Rd, Changsha 410005, Hunan, Peoples R China.;Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost & Therapeut Res Chine, 300 Xueshi Rd,Hanpu Sci & Educ Ind Pk, Changsha 410208, Hunan, Peoples R China.
关键词:
Hemorrhoids;Meta-analysis;Stapled hemorrhoidectomy;Transanal hemorrhoidal dearterialization
摘要:
Background and Objective: The aim of this study was to compare the outcomes of transanal hemorrhoidal dearterialization (THD) and stapled hemorrhoidectomy (SH) in the treatment of hemorrhoids by a meta-analysis. Methods: Randomized control trials (RCTs) comparing SH with THD were searched for in databases, including MEDLINE, PubMed, Web of science, Embase, and the Cochrane Library database. Data were independently extracted from each study, and a meta-analysis was performed using RevMan5.2 software. Results: Eight RCTs, including 977 patients, were included in this meta-analysis. No statistically significant differences were noted between THD and SH in terms of total complications (OR, 0.93; 95% CI, 0.69, 1.25), but a significant differences were noted in terms of bleeding (OR, 1.85; 95% CI, 1.10, 3.10). The total recurrence rate was higher in THD than in SH on short-term follow-up; however, the recurrence rate was equal in both the THD and SH groups on long-term follow-up. The present study showed that no significant difference between SH and THD in terms of postoperative pain (OR, 0.43; 95% CI, 0.43, 1.29), operative time (OR, 3.12; 95% CI, 7.01, 0.77), hospital time (OR, 0.00; 95% CI, 0.21, 0.20), time before returning to work (OR,-0.50; 95%CI, 4.42,3.43), and reoperation rate (OR, 1.81; 95% CI, 0.93, 3.54). Conclusion: Our meta-analysis indicated that THD and SH are equally effective techniques for the treatment of hemorrhoids. However, future studies addressing cost-effectiveness, satisfaction rate, and recurrence rate over a long follow-up period are needed to validate these results. Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
语种:
英文
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TLC-HPLC-Q-TOF-MS法快速鉴定柑橘提取物消毒液中桔皮素、蜜橘黄素、新橙皮苷和柚皮苷及其含量测定
作者:
袁志鹰;周晓倩;张梦通;周小江;曾光;...
期刊:
分析试验室 ,2018年37(9):993-997 ISSN:1000-0720
作者机构:
湖南中医药大学, 长沙, 410208;湖南省中药饮片标准化及功能工程技术中心, 湖南省中药饮片标准化及功能工程技术中心, 长沙, 410208;湖南省药食同源功能性食品工程技术中心, 湖南省药食同源功能性食品工程技术中心, 长沙, 410208;[袁志鹰] 湖南中医药大学, 长沙, 410208 湖南省中药饮片标准化及功能工程技术中心, 湖南省中药饮片标准化及功能工程技术中心, 长沙, 410208 湖南省药食同源功能性食品工程技术中心, 湖南省药食同源功能性食品工程技术中心, 长沙, 410208;[周晓倩; 张梦通; 曾光; 邓文祥] 湖南中医药大学, 长沙, 410208
关键词:
薄层色谱-高效液相色谱-四极杆飞行时间质谱法;桔皮素;蜜橘黄素;新橙皮苷;柚皮苷
摘要:
建立了薄层色谱-高效液相色谱-四极杆飞行时间质谱法联用技术 (TLC-HPLC-QTOF-M S) 快速鉴定柑橘提取物消毒液中桔皮素、蜜橘黄素、新橙皮苷和柚皮苷4种活性物质并测定其含量的方法.样品经氯仿-丙酮洗脱剂梯度洗脱, TLC检识, 半制备HPLC纯化, HPLCM S/M S鉴定及HPLC含量测定.结果表明, 以氯仿-丙酮 (3:1, V/V) 作为展开剂分离效果最好.以甲醇-水 (7:3, V/V) 作为流动相测定桔皮素和蜜橘黄素的含量, 以甲醇-0.2%乙酸 (13:7, V/V) 作为流动相对柚皮苷和新橙皮苷进行定性和定量分析, 分离度及峰形最佳.方法测定桔皮素、蜜橘黄素、新橙皮苷和柚皮苷含量的相关系数均大于0.999, 检测限分别为:0.3, 0.1, 0.4, 1.2μg/m L, 相对标准偏差分别为1.9%, 1.9%, 2.2%, 1.5%, 平均回收率分别为97.0%, 103.5%, 97.8%, 100.1%.方法可用于柑橘提取物消毒液质量控制.
语种:
中文
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中医药膳食品认证管理现状探讨
作者:
夏新斌;杨勇;吴玉冰;谢梦洲
( 谢梦洲 ) ;黄惠勇;...
期刊:
食品与机械 ,2018年34(8):207-210 ISSN:1003-5788
作者机构:
湖南中医药大学中医学博士后流动站, 湖南, 长沙, 410208;湖南省药食同源功能性食品工程技术研究中心, 湖南省药食同源功能性食品工程技术研究中心, 湖南, 长沙, 410208;湖南中医药大学药学院, 湖南, 长沙, 410208;湖南中医药大学中医学院, 湖南, 长沙, 410208;湖南省中医药管理局, 湖南, 长沙, 410001
关键词:
中医药膳;认证制度;功能性食品;特膳食品
摘要:
从中医药膳食品概念着手分析了中国现行食品药品管理法律法规束缚和制约中医药膳食品行业发展的问题,并针对目前中医药膳行业尚无明确的质量标准,指出必须在借鉴当前世界食品药品认证制度的基础上,针对中医药膳食品行业特点,制定符合中医药理论的中医药膳食品认证制度,促进中医药膳食品行业规范化、产业化。
语种:
中文
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基于证素辨证体系浅探2型糖尿病辨证研究概况
作者:
夏帅帅;曾光;向茗;邵峰;贺佐梅;...
期刊:
辽宁中医杂志 ,2018年45(7):1554-1556 ISSN:1000-1719
作者机构:
[夏帅帅; 吴华英; 黄惠勇; 邵峰; 向茗; 贺佐梅; 曾光] 湖南中医药大学
关键词:
证素;证素辨证;辨证论治;糖尿病;综述
摘要:
糖尿病以2型最为多见,作为慢性代谢性疾病,严重威胁人类健康。随着近年来人们对其研究不断深入,中医药在治疗糖尿病方面越来越显露出独特的优势。通过朱文锋先生创立的证素辨证体系,可用以科学、规范、权威的阐明糖尿病辨证论治,笔者试据此论述证素辨证体系下的糖尿病辨证研究进展,为规范中医临床辨证提供参考依据。
语种:
中文
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Seminar-案例教学法在中医诊断学教学中的应用探究
作者:
宋厚盼;曾梅艳;黄惠勇;凌智;简维雄
期刊:
高等教育研究学报 ,2018年41(2):116-120 ISSN:1672-8874
作者机构:
湖南中医药大学 中医诊断学湖南省重点实验室,湖南长沙,410208;湖南中医药大学 方剂学教研室,湖南长沙,410208;[宋厚盼; 简维雄; 黄惠勇; 凌智; 曾梅艳] 湖南中医药大学
关键词:
Seminar教学法;案例教学法;中医诊断学;教学研究
摘要:
将Seminar-案例教学法运用于"中医诊断学"教学,并探究其教学效果.与传统教学法比较,Seminar-案例教学法显著提高了学生的学习态度、 学习能力和对专业知识的掌握程度;接受Seminar-案例教学法的班级期末考核成绩明显高于接受传统教学的班级.Seminar-案例教学法可提高学生的综合素质和辨证思维能力,提升"中医诊断学"教学质量,值得中医药高等院校进一步探索与实践.
语种:
中文
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防治原发性肝癌膏方用药规律研究
作者:
邵峰;曾普华;郜文辉;谢梦洲
( 谢梦洲 ) ;贺佐梅;...
期刊:
亚太传统医药 ,2018年14(9):64-66 ISSN:1673-2197
作者机构:
[谢梦洲; 夏帅帅; 吴华英; 黄惠勇; 邵峰; 郜文辉; 贺佐梅] 湖南中医药大学;[曾普华] 湖南省中医药研究院附属医院
关键词:
原发性肝癌;膏方;用药规律
摘要:
目的:探索膏方治疗原发性肝癌的用药规律。方法:通过搜集文献,对符合纳入标准和排除标准的原发性肝癌文献中的药物进行分类,对其用药规律进行总结。结果:除膏方所需的辅料外,共涉及药物100余味,所出现的频次为182次,其中补虚药使用率最高(36.3%),其次是活血化瘀药(10.1%)、清热解毒药(7.1%)及利水渗湿药(4.9%),化痰药、解表药、消食药、化湿药再次之。结论:治疗原发性肝癌膏方用药有自身规律和特点,在辨证论治基础上应重视补虚药、活血化瘀药、清热解毒药及利水渗湿药的使用。
语种:
中文
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中医药治疗原发性肝癌用药规律的文献研究
作者:
邵峰;曾普华;郜文辉;贺佐梅;夏帅帅;...
期刊:
湖南中医杂志 ,2018年34(11):117-119 ISSN:1003-7705
作者机构:
[夏帅帅; 黄惠勇; 邵峰; 郜文辉; 刘通; 贺佐梅] 湖南中医药大学;[曾普华] 湖南省中医药研究院附属医院
关键词:
原发性肝癌;用药规律;文献研究;聚类分析;文献调查
摘要:
目的:探讨中医药治疗原发性肝癌的用药规律。方法:检索中国期刊全文数据库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)等数据库,收集中医药治疗原发性肝癌的文献。使用SPSS 21. 0软件,采用频次和聚类分析对中药处方进行数据挖掘。结果:共纳入有效文献108篇,含处方113首,其中涉及中药176味,频次1357次,使用频次排名前5位的药物依次为黄芪、茯苓、党参、白术、白花蛇舌草。中药用药类别依次为补虚药、清热药、理气药、活血化瘀药、利水渗湿药。聚类分析显示补脾益气、活血化瘀、清热解毒是临床上治疗原发性肝癌的常用法则。结论:益气健脾、清热解毒、活血化瘀是治疗原发性肝癌的基本法则;黄芪、党参、白术、白花蛇舌草、半枝莲、白芍、柴胡是治疗原发性肝癌的常用药物。
语种:
中文
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Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
作者:
Zhang, Shi-Ying;Yang, Kai-lin;Zeng, Liu-ting;Wu, Xiao-he* ;Huang, Hui-yong*
期刊:
International Journal of Endocrinology ,2018年2018:6484839 ISSN:1687-8337
通讯作者:
Huang, Hui-yong;Wu, Xiao-he
作者机构:
[Zhang, Shi-Ying; Zeng, Liu-ting; Yang, Kai-lin; Huang, Hui-yong] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.;[Zhang, Shi-Ying; Wu, Xiao-he] Jiangxi Prov Peoples Hosp, Nanchang 330006, Jiangxi, Peoples R China.
通讯机构:
[Huang, Hui-yong] H;[Wu, Xiao-he] J;Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.;Jiangxi Prov Peoples Hosp, Nanchang 330006, Jiangxi, Peoples R China.
摘要:
Objective. To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods. Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study’s registration number is CRD42018088474. The primary outcomes included glycosylated hemoglobin, fasting blood glucose, and fasting insulin. Result. Thirteen trials involving 765 patients were included. Compared with the control group, coenzyme Q10 may decrease the HbA1c (WMD −0.29; 95% CI −0.54, −0.03; P = 0 03) and the fasting blood glucose (WMD −11.21; 95% CI −18.99, −3.43; P = 0 005). For fasting insulin, there is also not strong evidence that confirms which one is better because there was no statistical difference (WMD −0.48; 95% CI −2.54, 1.57; P = 0 65). Conclusion. Based on current evidence, coenzyme Q10 may assist glycemic control, decrease TG, and improve HDL-C in patients with T2DM. Copyright © 2018 Shi-ying Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
语种:
英文
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Potential Metabolic Drug-Drug Interaction of Citrus aurantium L. (Rutaceae) Evaluating by Its Effect on 3 CYP450
作者:
Zhou, Lu;Cui, Man;Zhao, Linlin;Wang, Dongsheng;Tang, Tao;...
期刊:
Frontiers in Pharmacology ,2018年9(AUG):895 ISSN:1663-9812
通讯作者:
Qiu, Xinjian
作者机构:
[Zhou, Lu; Wang, Wenbo; Qiu, Xinjian; Tang, Tao; Wang, Dongsheng; Wang, Sheng] Cent S Univ, Xiangya Hosp, Dept Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China.;[Cui, Man] Shandong Univ Tradit Chinese Med, Med Serv Sect, Affiliated Hosp 2, Jinan, Shandong, Peoples R China.;[Zhao, Linlin] Cent S Univ, Hlth Management Ctr, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.;[Huang, Huiyong] Hunan Univ Chinese Med, Prov Key Lab Tradit Chinese Med Diagnost, Changsha, Hunan, Peoples R China.
通讯机构:
[Qiu, Xinjian] C;Cent S Univ, Xiangya Hosp, Dept Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China.
关键词:
CYP1A2;CYP2E1;CYP3A4;Fructus aurantii;drug-drug interaction
摘要:
Aim: Fructus aurantii (FA) is widely used in clinic as an expectorant and digestant herb in traditional Chinese medicine and proven to have a variety of pharmacological functions. FA is close to grapefruit either by botanical taxonomy or by their same components (flavonoids, etc.) and grapefruit has been proven to cause drug-drug interaction when co-administrated with CYP3A4 substrates. Besides, FA contains many compounds, such as flavonoids, which have been reported to impact the expressions of CYP450. However, the effect of FA on CYP450, whose change may affect drug safety and clinical efficacy attributed to drug-drug interaction, still remains unknown. Methods: The protein, mRNA expression and enzyme activity of CYP1A2, CYP3A4, and CYP2E1 in rat were determined by Western Blotting, RT-PCR method, the cocktail method, respectively, after orally administration of FA in succession for 7 days. CYP1A2, CYP3A4, and CYP2E1 mRNA expression were investigated in HepG2 cells following FA-medicated serum incubation for 24 h. Results: In rat, compared to the control group, CYP1A2, CYP3A4 protein, and mRNA expression were significantly induced consistent with the corresponding CYP activities; the protein expression of CYP2E1 was significantly upregulated, while the corresponding mRNA expression and enzyme activity showed no significant change. In HepG2 cells, compared to the control group, the mRNA expression of CYP1A2 and CYP3A4 was up-regulated statistically while CYP2E1 mRNA expression was not significantly induced or inhibited. Conclusion: FA may be a potential slight inducer of CYP1A2 and CYP3A4 and is unlikely to impact CYP2E1 until clinical researches are conducted. © 2018 Zhou, Cui, Zhao, Wang, Tang, Wang, Wang, Huang and Qiu.
语种:
英文
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百合药材、种植土壤及灌溉水中农药及重金属残留分析
作者:
袁志鹰;张梦通;陈乃宏;谢舒平;裴刚;...
期刊:
天然产物研究与开发 ,2018年30(11):1943-1949 ISSN:1001-6880
作者机构:
湖南中医药大学;湖南省中药饮片标准化及功能工程技术研究中心, 湖南省中药饮片标准化及功能工程技术研究中心;湖南省药食同源功能性食品工程技术研究中心, 湖南省药食同源功能性食品工程技术研究中心, 长沙, 410208;南京中医药大学, 南京, 210046;郴州市食品药品检验检测中心, 郴州, 423000
关键词:
百合;农药;重金属;安全评价
摘要:
对湘产药食两用植物卷丹百合的鲜药、干燥药材、产地土壤及灌溉水的安全性进行评价。采用气相色谱法对总六六六、总滴滴涕、甲氰菊酯、毒死蜱、百菌清进行测定,并用AFS-AAS法测定As、Hg、Pb、Cd、Cr和Cu含量。结果显示,6个采样区的土壤、灌溉水中六六六、滴滴涕、甲氰菊酯、毒死蜱均未见残留,百菌清残留量为ND0. 126 mg/kg;在百合鲜药、干燥药材中,六六六、滴滴涕、甲氰菊酯、毒死蜱、百菌清5种农药均未测出有残留,另除G-1、D-4样品中Cd残留量超标外,所有样品重金属均符合《植物和制剂对外贸易和贸易的绿色贸易标准》(WM/T2-2004)。根据污染指数评价,龙山具有优良的卷丹百合产地环境,适合生产符合现代质量要求的绿色百合。但研究发现百合对于土壤中镉的富集系数好,有必要加强百合主产区土壤改性进一步研究。
语种:
中文
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Design of a WeChat Learning Platform for Syndrome Differentiation
作者:
邓文祥;朱建平;刘应蛟;张弋戈;黄惠勇;...
期刊:
数字中医药(英文) ,2018年1(2):143-154 ISSN:2096-479X
作者机构:
[朱建平] Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;TCM Diagnostic Institute, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;[张弋戈; 张文安] Zhuhai Meianjaiyi Health Industry Investment Management Co., Ltd, Zhuhai, Guangdong 519000, China;[邓文祥; 黄惠勇] Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, TCM Diagnostic Institute, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
关键词:
辨证论治;学习平台;智能手机;微信程序
摘要:
目的开发一项用于智能手机的"中医辨证学习平台"小程序,以提高人们对健康的认知。方法利用微信的开发工具(版本:v1.01.170925)设计和调试该程序。统计学软件SPSS 17.0用于统计学分析。"视图容器""基础内容""表单""导航"和"多媒体"等组件用于该微信小程序的开发。详细的方法参照https://mp.weixin.qq.com/debug/wxadoc/dev/。结果本研究开发了名为中医辨证学习平台(DSDLP)的微信小程序。该程序主要包含基于微信的知识阅读、分类和辨证三方面内容。官方测试报告显示,CSDLP测试的7款android智能手机(被称为A、B、C、D、E、F和G)功能均正常。统计分析结果显示D、E、F和G的平均记忆比A、B和C低。F的平均比最高,G最低。所有智能手机的平均加载时间一致。音频和视频数据库均基于中医诊断学教材。本研究建立了一个包括51种疾病辨证分析的数据库。结论 CSDLP可以改进知识的可视化、学习过程和信息共享,就中医辨证论治的新技术的培养和发展而言,它可以帮助人们更好地理解中医。
语种:
中文
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固相萃取-离子色谱法同时测定卷丹产地灌溉水中7种无机阴离子
作者:
袁志鹰;张梦通;谢梦洲;陈乃宏;谢舒平;...
期刊:
分析科学学报 ,2018年34(6):762-766 ISSN:1006-6144
作者机构:
湖南中医药大学, 湖南, 长沙, 410208;湖南省中药饮片标准化及功能工程技术研究中心, 湖南省中药饮片标准化及功能工程技术研究中心, 湖南, 长沙, 410208;湖南省药食同源功能性食品工程技术研究中心, 湖南省药食同源功能性食品工程技术研究中心, 湖南, 长沙, 410208;南京中医药大学, 江苏, 南京, 210023;郴州市食品药品检验检测中心, 湖南, 郴州, 423000
关键词:
离子色谱法;卷丹百合;灌溉水
摘要:
建立了一种固相萃取-离子色谱法同时测定卷丹百合产地灌溉水中7种无机阴离子的简便、快速分析方法。将采集的灌溉水过SPE-C_(18)小柱去除有机杂质,0.22μm微孔滤膜过滤后,取续滤液进样分析。采用IonPac AS19柱(250×4 mm,5μm)为离子交换柱,IonPac AG19柱(50×4 mm)为保护柱;以20.0 mmol/L KOH溶液为流动相,流速为1.30 mL/min,柱温为30℃,可在18 min内完成对F~-、Cl~-、Br~-、NO_2~-、NO_3~-、SO_4~(2-)和PO_4~(3-)这7种阴离子的同时分离检测。7种阴离子在较宽范围内有良好的线性关系和精密度,7种阴离子线性范围分别为0.01~20、0.01~20、0.02~20、0.04~20、0.3~20、0.01~20、0.01 ~20 mg/L,相关系数R大于0.9995。平均加标回收率为92.4%~101.9%,相对标准偏差为0.19%~4.47%(n=3)。该方法简便快速、灵敏准确,能同时测定农业灌溉水中上述7种无机阴离子。对卷丹百合产地环境监控具有重要意义。
语种:
中文
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日本功能性食品发展对中国药膳产业发展的启示
作者:
夏新斌;刘金红;谢梦洲;黄惠勇;李玲
期刊:
食品与机械 ,2018年34(11):205-207,220 ISSN:1003-5788
作者机构:
湖南中医药大学人文与管理学院, 湖南, 长沙, 410208;湖南省药食同源工程功能性食品工程技术研究中心, 湖南省药食同源工程功能性食品工程技术研究中心, 湖南, 长沙, 410208;[夏新斌] 湖南中医药大学人文与管理学院, 湖南, 长沙, 410208 湖南省药食同源工程功能性食品工程技术研究中心, 湖南省药食同源工程功能性食品工程技术研究中心, 湖南, 长沙, 410208;[刘金红; 李玲] 湖南中医药大学人文与管理学院, 湖南, 长沙, 410208;[谢梦洲; 黄惠勇] 湖南省药食同源工程功能性食品工程技术研究中心, 湖南省药食同源工程功能性食品工程技术研究中心, 湖南, 长沙, 410208
关键词:
功能性食品;药膳;药食同源
摘要:
概述并总结了日本功能性食品发展的历程、发展特点及管理经验,提出其对中国药膳产业发展的启示,指出政府主管部门应明确管理责任,加强市场监管,同时企业需要加大科技创新,吸取中华优秀的中医文化,发掘药食同源的产品精髓,努力地开发出新产品。
语种:
中文
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