作者机构：
[Lv, Jingwei; Lu, Cong; Xu, Pan; Dong, Liming; Liu, Xinmin] Chinese Acad Med Sci, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing, Peoples R China.;[Lv, Jingwei; Lu, Cong; Xu, Pan; Dong, Liming; Liu, Xinmin] Peking Union Med Coll, Beijing, Peoples R China.;[Shi, Zhe] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.;[Li, Yinghui; Qu, Lina; Liu, Xinmin] China Astronaut Res & Training Ctr, Natl Lab Human Factors Engn, State Key Lab Space Med Fundamentals & Applicat, Beijing, Peoples R China.
通讯机构：
[Liu, Xinmin] C;China Astronaut Res & Training Ctr, Natl Lab Human Factors Engn, State Key Lab Space Med Fundamentals & Applicat, Beijing, Peoples R China.
摘要：
Editor: Timothy R. Elliott, PhDQuarterly, beginning in FebruaryRehabilitation Psychology is a quarterly peer-reviewed journal that publishes articles in furtherance of the mission of Division 22 (Rehabilitation Psychology) of the American Psychological Association and to advance the science and practice of rehabilitation psychology.Rehabilitation psychologists consider the entire network of biological, psychological, social, environmental, and political factors that affect the functioning of persons with disabilities or chronic illness. Given the breadth of rehabilitation psychology, the journal's scope is broadly defined. Suitable submissions include papers describing experimental investigations, survey research, evaluations of specific interventions, outcome studies, historical perspectives, relevant public policy issues, conceptual/theoretical formulations with implications for clinical practice, reviews of empirical research, detailed case studies, and professional issues.Papers will be evaluated for their importance to the field, scientific rigor, novelty, suitability for the journal, and clarity of writing. The primary determinant of editorial decisions is whether the paper enlarges both the understanding of important psychological problems in rehabilitation and the capacity to offer effective assistance in ameliorating those problems.Coverage in the Journals@Ovid database begins with the Spring 1995 issue.
期刊：
Journal of Ethnopharmacology,2017年201:73-81 ISSN：0378-8741
通讯作者：
Liu, Xinmin
作者机构：
[Pan, Ruile; Lu, Cong; Sun, Xiuping; Shi, Zhe; Liu, Xinmin] Chinese Acad Med Sci, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing, Peoples R China.;[Pan, Ruile; Lu, Cong; Sun, Xiuping; Shi, Zhe; Liu, Xinmin] Peking Union Med Coll, Beijing, Peoples R China.;[Chen, Shanguang; Li, Yinghui; Qu, Lina] China Astronaut Res & Training Ctr, Beijing, Peoples R China.;[Sun, Lihua; Dang, Haixia] Chinese Acad Chinese Med Sci, Beijing, Peoples R China.;[Chen, Lingling; Bu, Lanlan; Liu, Xinmin] Hunan Univ Tradit Chinese Med, Changsha, Hunan, Peoples R China.
通讯机构：
[Liu, Xinmin] C;[Liu, Xinmin] P;[Liu, Xinmin] H;Chinese Acad Med Sci, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing, Peoples R China.;Peking Union Med Coll, Beijing, Peoples R China.
摘要：
The beta 1-adrenergic receptor (AR) is the primary beta-AR subtype in the heart and is the target of metoprolol (Met), which is commonly used to treat angina and hypertension. Previous studies have revealed a positive correlation between the methylation levels of the adrenoreceptor beta 1 gene (Adrb1) promoter in the myocardium with the antihypertensive activity of Met in spontaneously hypertensive rats (SHR), which affects beta 1-AR expression in H9C2 cells. The aim of the present study was to investigate the effects of myocardial beta 1-AR downregulation using short-hairpin RNA (shRNA) against Adrb1 on the antihypertensive activity of Met in SHR. Recombinant adeno-associated virus type 9 (rAAV9) vectors carrying Adrb1 shRNA (rAAV9-Adrbl) or a negative control sequence (rAAV9-NC) were generated and used to infect rat hearts via the pericardial cavity. The results of reverse transcription-quantitative polymerase chain reaction, immunohistochemistry and western blotting analyses demonstrated that cardiac beta 1-AR expression in the rAAV9-Adrbl group was significantly downregulated when compared with the rAAV9-NC group (P<0.001, P<0.001 and P=0.032, respectively). In addition, a greater reduction in systolic blood pressure (SBP) was observed in the rAAV9-NC group compared with the rAAV9-Adrbl group following Met treatment (P=0.035). Furthermore, downregulation of myocardial beta 1-AR was associated with a significant decrease in SBP (P<0.001). In conclusion, these data suggest that suppression of beta 1-AR expression in the myocardium reduces SBP and sensitivity to Met in SHR.
作者机构：
[Zeng, Fang; Lan, Lei; Liang, Fanrong; Li, Zhengjie; Guo, Taipin; Wu, Feng; Li, Ying; Gao, Yujie; Yang, Jie; Dong, Mingkai] Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China.;[Li, Zhengjie] Xiamen Univ, Dept Tradit Chinese Med, Coll Med, Xiamen, Fujian, Peoples R China.;[Sun, Sharon; Kong, Jian; Makris, Nikos] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.;[Sun, Sharon; Kong, Jian; Makris, Nikos] Harvard Med Sch, Boston, MA USA.;[Sun, Sharon; Kong, Jian; Makris, Nikos] Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA.
通讯机构：
[Liang, Fanrong] C;Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China.
关键词：
Acupuncture;migraine without aura;fMRI;independent component analysis;frontoparietal network;resting-state functional connectivity
摘要：
Aims: This study aims to investigate the resting-state functional connectivity (rs-fc) of the right frontoparietal network (rFPN) between migraineurs and healthy controls (HCs) in order to determine how the rFPN rs-fc can be modulated by effective treatment. Methods: One hundred patients and 46 matched HCs were recruited. Migraineurs were randomized to verum acupuncture, sham acupuncture, and waiting list groups. Resting-state functional magnetic resonance imaging data were collected before and after longitudinal treatments. Independent component analysis was applied in the data analysis. Results: We found that migraineurs showed decreased rs-fc between the rFPN and bilateral precuneus compared with HCs. After treatments (real and sham), rFPN rs-fc with the precuneus was significantly reduced. This reduction was associated with headache intensity relief. In order to explore the role of the precuneus in acupuncture modulation, we performed a seed-based rs-fc analysis using the precuneus as a seed and found that the precuneus rs-fc with the bilateral rostral anterior cingulate cortex/medial prefrontal cortex, ventral striatum, and dorsolateral prefrontal cortex was significantly enhanced after treatment. Conclusion: Our results suggest that migraineurs are associated with abnormal rFPN rs-fc. An effective treatment, such as acupuncture, may relieve symptoms by strengthening the cognitive adaptation/coping process. Elucidation of the adaptation/coping mechanisms may open up a new window for migraine management.
摘要：
The root of Wikstroemia indica has been widely used in China as folk medicine for the treatment for arthritis, whooping cough, cancer, and bacillosis. However, the constituents which have antibacterial activity were not clarified yet. In this study, the antibacterial effect of five extracts from W. indica on Escherichia coli was evaluated by microcalorimetry coupled with agar dilution method. The ethanol extract of W. indica was isolated with organic solvents of different polarities including petroleum (P.E.) extract, chloroform (CHCl3) extract, ethyl acetate (EtOAc) extract, n-butylalcohol (nBuOH) extract, and residue extract. The metabolic profiles of E. coli growth at 37 A degrees C were measured by microcalorimetry. According to the principal component analysis, k (1), k (2), and P (1) were obtained from heat flow power-time (HFP-time) curve. The agar dilution method was performed to verify the results of thermodynamics. The results of microcalorimetric experiment indicated that EtOAc fraction demonstrated the strongest antibacterial activity with half-inhibitory concentration of 92.4 mu g mL(-1). Meanwhile, similar results were gained from the common method of agar diffusion, which suggested that EtOAc extract could be further developed as antibacterial bioactive fraction of W. indica. Altogether, microcalorimetry is a useful technique to provide sufficient quantitative information and evaluate the antimicrobial effect with its sensitive.
作者机构：
[Wu Bin; Liu Jingjing; Li Yanping; Wu, B; Zhou Hongmei] Chongqing Hosp Tradit Chinese Med, Dept Rheumatol, Chongqing 400021, Peoples R China.;[Liu Jingjing; Zhou Hongmei] Hunan Univ Tradit Chinese Med, Grad Sch, Changsha 410007, Hunan, Peoples R China.
通讯机构：
[Li, YP; Wu, B] C;Chongqing Hosp Tradit Chinese Med, Dept Rheumatol, Chongqing 400021, Peoples R China.
关键词：
Primary Sjogren's syndrome;Clinical research;Meta-analysis;Medicine, Chinese Traditional
摘要：
OBJCTIVE: To compare the clinical efficacy of Traditional Chinese Medicine (TCM) to Western Medicine in the treatment of primary Sjogren's syndrome (pSS). METHODS: We collected randomized controlled trials of TCM vs Western Medicine for the treatment of pSS in Chinese and foreign databases. The study quality was evaluated as suggested in the Cochrane Handbook. The Meta-analysis was performed using Review Manager 5.0 statistical software. RESULTS: A total of 31 randomized controlled trials with 2137 cases were retrieved. The efficiencies of TCM and control treatments were 87.18% and 65.63%, respectively. The results of heterogeneity tests showed that the data were homogeneous (P = 0.83), thus a fixed effects model was used for analysis. The results revealed an odds ratio of 3.74 with a 95% confidence interval of 2.99-4.69. The overall effectiveness value was 11.48 (P < 0.000 01). These results suggest the efficacy of TCM therapy for pSS better than Western Medicine. CONCLUSION: Although our findings reveal that the TCM treatment of pSS had significant advantages over its counterpart, there were some flaws in the studies included. The findings warrant further investigation.
作者机构：
[Zeng, Fang; Zhou, Si-Yuan; Li, Ying; Zheng, Hui] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Coll, Chengdu, Sichuan, Peoples R China.;[Zhang, Wei] Hunan Univ Tradit Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.;[Zheng, Hua-Bin] Chengdu Univ Tradit Chinese Med, Teaching Hosp, Chengdu, Sichuan, Peoples R China.;[Zhang, Wei; Liu, Zhi-Shun] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China.;[Zhu, Bing; Rong, Pei-Jing; Jing, Xiang-Hong] China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Beijing, Peoples R China.
通讯机构：
[Liu, Zhi-Shun; Zhu, Bing] C;China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China.;China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Beijing, Peoples R China.
摘要：
Diarrhea-predominant irritable bowel syndrome (IBS-D) and functional diarrhea (FD) are highly prevalent, and the effectiveness of acupuncture for managing IBS-D and FD is still unknown. The aim of this study was to compare the effectiveness of electroacupuncture with loperamide. It was a prospective, randomized, parallel group controlled trial. A total of 448 participants were randomly assigned to He electroacupuncture group (n = 113), Shu-Mu electroacupuncture group (n = 111), He-Shu-Mu electroacupuncture group (n = 112), or loperamide group (n = 112). Participants in the 3 acupuncture groups received 16 sessions of electroacupuncture during a 4-week treatment phase, whereas participants in the loperamide group received oral loperamide 2 mg thrice daily. The primary outcome was the change from baseline in stool frequency at the end of the 4-weeks treatment. The secondary outcomes were the Bristol scale, the MOS 36-item short form health survey (SF-36), the weekly average number of days with normal defecations and the proportion of adverse events. Stool frequency was significantly reduced at the end of the 4-week treatment in the 4 groups (mean change from baseline, 5.35 times/week). No significant difference was found between the 3 electroacupuncture groups and the loperamide group in the primary outcome (He vs. loperamide group [mean difference 0.6, 95% CI, –1.2 to 2.4]; Shu-Mu vs. loperamide group [0.4, 95% CI, –1.4 to 2.3]; He-Shu-Mu vs. loperamide group [0.0, 95% CI, –1.8 to 1.8]). Both electroacupuncture and loperamide significantly improved the mean score of Bristol scale and increased the weekly average number of days with normal defecations and the mean scores of SF-36; they were equivalent in these outcomes. However, the participants in electroacupuncture groups did not report fewer adverse events than those in the loperamide group. Similar results were found in a subgroup analysis of separating patients with IBS-D and FD patients. Electroacupuncture is equivalent to loperamide for reducing stool frequency in IBS-D and FD patients. Further studies on cost effectiveness of acupuncture are warranted.
摘要：
Reperfusion therapy is widely used to treat acute myocardial infarction (AMI). However, further injury to the heart induced by rapidly initiating reperfusion is often encountered in clinical practice. A lack of pharmacological strategies in clinics limits the prognosis of patients with myocardial ischemia-reperfusion injury (MIRI). Dihydromyricetin (DMY) is one of the most abundant components in vine tea, commonly known as the tender stems and leaves of Ampelopsis grossedentata. The aim of this study was to evaluate the cardioprotection of DMY against myocardial ischemia-reperfusion (I/R) injury and to further investigate the underlying mechanism. An I/R injury was induced by left anterior descending coronary artery occlusion in adult male rats in vivo and a hypoxia-reoxygenation (H/R) injury in H9c2 cardiomyocytes in vitro. We found that DMY pretreatment provided significant protection against I/R-induced injury, including enhanced antioxidant capacity and inhibited apoptosis in vivo and in vitro. This effect correlated with the activation of the PI3K/Akt and HIF-1 alpha signaling pathways. Conversely, blocking Akt activation with the PI3K inhibitor LY294002 effectively suppressed the protective effects of DMY against I/R-induced injury. In addition, the PI3K inhibitor partially blocked the effects of DMY on the upregulation of Bcl-2, Bcl-xl, procaspase-3, -8, and -9 protein expression and the downregulation of HIF-1 alpha, Bnip3, Bax, Cyt-c, cleaved caspase-3, -8, and -9 protein expression. Collectively, these results showed that DMY decreased the apoptosis and necrosis by I/R treatment, and PI3K/Akt and HIF-1 alpha plays a crucial role in protection during this process. These observations indicate that DMY has the potential to exert cardioprotective effects against I/R injury and the results might be important for the clinical efficacy of AMI treatment.
摘要：
Objective： To study the effects of Xintongtai（心痛泰, XTT） on levels of serum lipid and aortic NF-κB p65, TNF-α and IL-10 in rabbits with atherosclerosis. Methods： A total of 120 clean grade healthy Japanese rabbits were randomly divided into control group, model group, low-dose XTT group, middle-dose XTT group, high-dose XTT group and Rosuvastatin group. All rabbits were sacrificed by high-fat diet and immunologic injury. The drug intervention groups were treated with the corresponding drugs for 60 days, then serum lipid, tumor necrosis factor-α（TNF-α）, interleukin-6（IL-10） were tested by Immunohistochemistry. The activity expression of NF-κB p65 in thoracic aortas was tested by Western Blot, and NF-κB-p65-m RNA was tested by Real-time quantitative PCR（Rt-PCR）. Results： Compared with model group, the XTT and Rosuvastatin group could decrease the content of blood lipid（P〈0.01, P〈0.05）. Variation of NF-κB-p65, IL-10 and TNF-α in the middle-dose XTT, high-dose XTT and Rosuvastatin groups were significant than model group（P〈0.01）. Conclusions： The XTT can reduce inflammatory response of atherosclerosis, and its mechanism probably related to lower serum lipid, reduce the expression of NF-κB-p65, TNF-α, and promote the expression of IL-10.
