作者机构：
湖南中医药大学药学院,湖南长沙410208;湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208;中药成药性与制剂制备湖南省重点实验室,湖南长沙410208;[杨岩; 肖佳妹] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Laboratory of Supramolecular Mechanism and Mathematic-Physics Characteristic of Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China;[贺福元; 杨岩涛] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Laboratory of Supramolecular Mechanism and Mathematic-Physics Characteristic of Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Key Laboratory of Druggability and Preparation of Chinese Medicine, Changsha, 410208, China
通讯机构：
[Yang, YT; Pei, G] H;[Lu, Jiandong] S;Hunan Univ Chinese Med, Pharm Coll, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.;Shenzhen Tradit Chinese Med Hosp, 1 Fuhua Rd, Shenzhen 518033, Guangdong, Peoples R China.
关键词：
Triterpenoids from yeyachun;Phenolic acids from danshen;Liver fibrosis;Intestinal flora;Metabolites
摘要：
yeyachun and danshen exist as Chinese patent medicine, Xuemai Tong, and are clearly effective at alleviating liver fibrosis (LF). Previous studies have indicated that triterpenoids from yeyachun (EFT), and phenolic acids from danshen (SMP) are effective in the treatment of LF. The regulation of intestinal flora is an effective method for treating LF. The aim of this study was to investigate the effect of a mixture of EFT and SMP on carbon tetrachloride (CCl4) induced LF. Our results showed the mixture significantly decreased liver damage and fibrosis index, and maintained liver tissue composition, compared to the model group. Moreover, the imbalance of symptoms of intestinal flora was improved. The mixture also caused changes to metabolites of gut flora. Furthermore, the expression of CD68 in liver tissues from the treated groups was significantly decreased when compared to the model group. However, no significant difference was observed from microstructure of gut tissues and LPS concentrations in the serum between mixture treated mice and model mice. This study suggests that the mixture of EFT and SMP had a significant effect on CCl4 induced LF, and the mechanism of this action, at least in part, involved the regulation of intestinal flora and their metabolites. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
作者机构：
[李姣; 裴刚; 王圣楠; 罗彩玉; 易子漾] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China;Hunan Key Laboratory of Druggability and Preparation of Chinese Medicine, Changsha, 410208, China;Laboratory of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China;[肖佳妹; 杨岩] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Laboratory of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China;[杨岩涛] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Key Laboratory of Druggability and Preparation of Chinese Medicine, Changsha, 410208, China, Laboratory of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China
作者机构：
[肖美凤] College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Hunan Provincial Key Laboratory of Drugability and Preparation Modification of Traditional Chinese Medicine Changsha 410208, China;[段晓鹏] College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine Changsha 410208, China;[邓凯文] The First Affinity Hospital, Hunan University of Chinese Medicine Changsha 410007, China;[刘文龙; 贺福元; 杨岩涛] College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Hunan Provincial Key Laboratory of Drugability and Preparation Modification of Traditional Chinese Medicine Changsha 410208, China Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine Changsha 410208, China
通讯机构：
The First Affinity Hospital, Hunan University of Chinese Medicine, Changsha, China
作者机构：
[肖美凤; 贺福元; 周逸群; 周晋; 杨岩涛; 刘文龙; 张雨恬] Hunan Provincial Key Laboratory of Druggability and Preparation Modification of Traditional Chinese Medicine, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China;[刘红宇] The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China
通讯机构：
[Liu, W.-L.; He, F.-Y.] H;Hunan Provincial Key Laboratory of Druggability and Preparation Modification of Traditional Chinese Medicine, China
