作者：
Nie, Duorui;Liu, Siyu;Cai, Si;Xing, Xiaoqi;Xu, Fei
期刊：
Advances in Therapy,2022年39(11):5043-5057 ISSN：0741-238X
通讯作者：
Fei Xu
作者机构：
[Nie, Duorui; Liu, Siyu] Hunan Univ Chinese Med, Grad Sch, Changsha, Peoples R China.;[Cai, Si] China Pharmaceut Univ, Inst Technol, Nanjing, Peoples R China.;[Xing, Xiaoqi; Xu, Fei] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China.;[Xu, Fei] Hunan Engn Technol Res Ctr Bioact Subst Discovery, Changsha, Peoples R China.;[Xu, Fei] Hunan Prov Sino US Int Joint Res Ctr Therapeut Dr, Changsha, Peoples R China.
通讯机构：
[Fei Xu] C;College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Hunan Engineering Technology Research Center for Bioactive Substance Discovery of Chinese Medicine, Changsha, China<&wdkj&>Hunan Province Sino-US International Joint Research Center for Therapeutic Drugs of Senile Degenerative Diseases, Changsha, China
摘要：
INTRODUCTION: Chemotherapy (CT) is the main treatment for patients with unresected pancreatic cancer (PC). Whether the addition of radiotherapy to chemotherapy improves the prognosis of elderly patients with unresected PC is unclear. The aim of our study was to compare the efficacy of chemoradiotherapy (CRT) with chemotherapy alone in elderly patients with unresected PC. METHODS: The clinical data of elderly patients with unresected PC who received chemotherapy between 2004 and 2017 were determined from the Surveillance, Epidemiology, and End Results (SEER) database, and the patients were divided into CT and CRT groups. The primary outcome was overall survival (OS), and secondary endpoints were cancer-specific survival (CSS) and cancer-specific mortality (CSM). Propensity matching analysis (PSM) was used to balance the differences between the two groups. OS and CSS were assessed using Kaplan-Meier analysis, while CSM was assessed using a competing risk model. Subgroup analyses were also performed, and Cox regression was used to adjust for confounding factors. RESULTS: A total of 17,814 patients were diagnosed with PC including 14,222 who received CT alone and 3592 who received CRT. The 1-year OS of the CT and CRT groups after PSM was 30.1% and 40.8%, and the 1-year CSS was 31.4% and 42.1%, respectively. Overall, the CRT group had better OS, CSS, and CSM rates than the CT group before and after PSM (P < 0.05). After adjustment for age, sex, race, histological grade, stage, and other factors, the CRT group still had a lower risk of death than the CT group, and subgroup analysis further revealed the survival benefit of CRT in each population. CONCLUSIONS: CRT improves the outcome of patients with non-surgical PC over 65years of age. But prospective studies are needed to validate our results.
摘要：
To repair the blood-brain barrier (BBB) after traumatic brain injury (TBI) remains a multidisciplinary challenge. No first-line drugs are available. Here, we reported a novel and non-toxic functional negative-charged carbon dots (CDs) generated from green Semen pruni persicae and Carthamus tinctorius L. (TH-CDs) through a hydrothermal synthesis without any organic solvent. The surface of TH-CDs retained part functional groups of active pharmacophores from both drugs. TH-CDs could improve the neurological function, brain edema, neuronal damage, and the BBB permeability by tail vein injection of mice models without systemic toxicity. Furthermore, higher expression of tight junction proteins claudin 5 and ZO-1 was observed after TH-CDs administration, which may be due to the electrostatic interaction between TH-CDs and claudin 5. Our study highlights an inexpensive, green, non-toxic, and intravenous functional TH-CD, which represents a potential TBI treatment strategy.
作者：
Wang, Xian-jing;Hu, Rong;Huang, Qiong-ying;Peng, Qing-hua;Yu, Juan
期刊：
Evidence-Based Complementary and Alternative Medicine,2022年2022 ISSN：1741-427X
通讯作者：
Yu, J.
作者机构：
[Peng, Qing-hua; Hu, Rong; Wang, Xian-jing; Huang, Qiong-ying] Hunan Univ Chinese Med, Changsha, Peoples R China.;[Peng, Qing-hua; Yu, Juan; Hu, Rong; Wang, Xian-jing; Huang, Qiong-ying] Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha, Peoples R China.;[Yu, Juan] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Peoples R China.
通讯机构：
Hunan Prov. Key Lab. for the Prev. and Treatm. of Ophthalmol. and Otolaryngol. Dis. with Traditional Chinese Med., Changsha, China
摘要：
<i>Objective</i>. To observe the protective effect of gynostemma glycosides on retinal ganglion cells in rats with chronically high intraocular pressure. <i>Materials and Methods</i>. A total of 60 rats were randomly divided into group A (the blank group, 10 rats) and chronic high IOP model group (50 rats). The IOP model group (IOP above 22 mmHg) was then randomly divided into an additional 5 groups (10 rats per group): group B (negative control group) treated with normal saline; group C treated with gynostemma glycosides 25 mg/(kg-d); group D treated with gynostemma glycosides 50 mg/(kg-d); group E treated with gynostemma glycosides 100 mg/(kg-d); and group F (positive control group) treated with VitB1 and VitB12. The eyes of each rat were monitored from day 1 to 14 (D1–D14). On day 14, rats were euthanized, after which retinal tissue and optic nerve were examined using real-time PCR, western blot, HE staining, LFB staining, and TUNEL assay. <i>Results</i>. Groups A, C, D, E, and F had significantly lower expression of CD11b, GFAP, Brn3<i>α</i>, and more TUNEL cells than in group B (all <span class="inline_break"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="19.289pt" style="vertical-align:-0.6370001pt" id="M1" height="9.2729pt" version="1.1" viewBox="-0.0498162 -8.6359 19.289 9.2729"><g transform="matrix(.013,0,0,-0.013,0,0)"><path id="g113-81" d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"/></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><path id="g117-91" d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"/></g></svg><span class="irelop"/><span class="nowrap"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="21.918pt" style="vertical-align:-0.6370001pt" height="9.2729pt" version="1.1" viewBox="22.8711838 -8.6359 21.918 9.2729"><g transform="matrix(.013,0,0,-0.013,22.921,0)"><path id="g113-49" d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"/></g><g transform="matrix(.013,0,0,-0.013,29.161,0)"><path id="g113-47" d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"/></g><g transform="matrix(.013,0,0,-0.013,32.125,0)"><use xlink:href="#g113-49"/></g><g transform="matrix(.013,0,0,-0.013,38.365,0)"><path id="g113-54" d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"/></g></svg>).</span></span> Moreover, the relative expression of STAT3 mRNA and JAK2 (mRNA and protein) in groups A, C, D, E, and F was significantly lower than in group B (<span class="inline_break"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="19.289pt" style="vertical-align:-0.6370001pt" id="M2" height="9.2729pt" version="1.1" viewBox="-0.0498162 -8.6359 19.289 9.2729"><g transform="matrix(.013,0,0,-0.013,0,0)"><use xlink:href="#g113-81"/></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><use xlink:href="#g117-91"/></g></svg><span class="irelop"/><span class="nowrap"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="21.918pt" style="vertical-align:-0.6370001pt" height="9.2729pt" version="1.1" viewBox="22.8711838 -8.6359 21.918 9.2729"><g transform="matrix(.013,0,0,-0.013,22.921,0)"><use xlink:href="#g113-49"/></g><g transform="matrix(.013,0,0,-0.013,29.161,0)"><use xlink:href="#g113-47"/></g><g transform="matrix(.013,0,0,-0.013,32.125,0)"><use xlink:href="#g113-49"/></g><g transform="matrix(.013,0,0,-0.013,38.365,0)"><use xlink:href="#g113-54"/></g></svg>),</span></span> while in group E, the expression was lower than in group D (<span class="inline_break"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="19.289pt" style="vertical-align:-0.6370001pt" id="M3" height="9.2729pt" version="1.1" viewBox="-0.0498162 -8.6359 19.289 9.2729"><g transform="matrix(.013,0,0,-0.013,0,0)"><use xlink:href="#g113-81"/></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><use xlink:href="#g117-91"/></g></svg><span class="irelop"/><span class="nowrap"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="21.918pt" style="vertical-align:-0.6370001pt" height="9.2729pt" version="1.1" viewBox="22.8711838 -8.6359 21.918 9.2729"><g transform="matrix(.013,0,0,-0.013,22.921,0)"><use xlink:href="#g113-49"/></g><g transform="matrix(.013,0,0,-0.013,29.161,0)"><use xlink:href="#g113-47"/></g><g transform="matrix(.013,0,0,-0.013,32.125,0)"><use xlink:href="#g113-49"/></g><g transform="matrix(.013,0,0,-0.013,38.365,0)"><use xlink:href="#g113-54"/></g></svg>).</span></span> <i>Conclusion</i>. Gynostemma glycosides protect retinal ganglion cells in rats with chronically high intraocular pressure possibly associated with the STAT3/JAK2 signaling pathway.
摘要：
BACKGROUND: Chronic atrophic gastritis (CAG) is an important stage of precancerous lesions of gastric cancer, and also a key period of drug intervention. However, there is still a lack of drugs to maintain the treatment of CAG until the advent of moluodan. OBJECTIVE: This study was conducted to assess the clinical efficacy of moluodan in the treatment of CAG by meta-analysis and trial sequential analysis. METHODS: China National Knowledge Infrastructure, China Biology Medicine, VIP, Wanfang, Embase, PubMed, the Cochrane Library, and Web of Science databases were searched, all with the time limit from database establishment to July 2022. The published randomized controlled trials of moluodan for CAG were conducted for meta-analysis and trial sequential analysis. RESULTS: 7 studies with a total sample size of 1143 cases were included. Compared to folic acid/vitamins, moluodan alone significantly increased the effective rate of pathological detection (relative risk [RR] = 1.73, 95% confidence interval [95%CI] = [1.48,2.02], P < .00001), and moluodan in combination with folic acid/vitamins significantly increased the effective rates of pathological detection (RR = 1.37, 95%CI = [1.23,1.52], P < .00001), gastroscopy (RR = 1.37, 95%CI = [1.18,1.60], P < .0001) and symptoms (RR = 1.25, 95%CI = [1.13,1.38], P < .0001). Harbord regression showed no publication bias (P = .22). Quality of evidence evaluation demonstrated moderate quality of evidence for all indicators. CONCLUSIONS: Moluodan can improve the effective rates of pathological examination, gastroscopy and symptoms in patients with CAG, and play a role in slowing down the disease progression and reducing clinical symptoms. It may be a potential drug for the treatment of CAG and has the value of further exploration.
通讯机构：
Neuropsychiatric Imaging Center, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, China
关键词：
Introduction;Materials and Methods;Results;Discussion;Conclusion;Abstract;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interests;Authors’ Contributions;Funding Statement;Acknowledgements;Acknowledgments;Supplementary Materials;Reference;Dataset Description;Dataset Files;Abstract;Introduction;Introduction and Materials;Introduction and Methods;Materials;Materials and Methods;Methods;Results;Discussion;Results and Discussion;Discussion and Conclusion;Results and Conclusion;Conclusion;Conclusions;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interest;Authors’ Contributions;Funding Statement;Acknowledgements;Supplementary Materials;References;Appendix;Abbreviations;Preliminaries;Introduction and Preliminaries;Notation;Proof of Theorem;Proofs;Analysis of Results;Examples;Numerical Example;Applications;Numerical Simulation;Model;Model Formulation;Systematic Palaeontology;Nomenclatural Acts;Taxonomic Implications;Experimental;Synthesis;Overview;Characterization;Background;Experimental;Theories;Calculations;Model Verification;Model Implementation;Geographic location;Study Area;Geological setting;Data Collection;Field Testing;Data and Sampling;Dataset;Literature Review;Related Works;Related Work;System Model;Methods and Data;Experimental Results;Results and Analysis;Evaluation;Implementation;Case Presentation;Case Report;Search Terms;Case Description;Case Series;Background;Limitations;Additional Points;Case;Case 1;Case 2 etc.;Concern Details;Retraction Details;Copyright;Related Articles
摘要：
Objective. This study is aimed at exploring the regional changes in brain cortical morphology (thickness, volume, and surface area) in the early-blind adolescents (EBAs) by using the surface-based morphometric (SBM) method. Methods. High-resolution structural T1-weighted images (T1WI) of 23 early-blind adolescents (EBAs) and 21 age- and gender-matched normal-sighted controls (NSCs) were acquired. Structural indices, including cortical thickness (CT), cortical volume (CV), and surface area (SA), were analyzed by using FreeSurfer software, and the correlations between structural indices and the blindness duration were computed by Pearson correlation analysis. Results. Compared to controls, EBAs had significantly reduced CV and SA mainly in the primary visual cortex (V1) and decreased CV in the left vision-related cortices (r-MFC). There were no regions that EBAs had a significantly larger CV or SA than NSCs. EBAs had significantly increased CT in the V1 and strongly involved the visual cortex (right lateral occipital gyrus, LOG.R) and the left superior temporal gyrus (STG.L), while it had decreased CT in the left superior parietal lobule (SPL.L) and the right lingual gyrus (LING.R). Additionally, no correlation was found between cortical morphometric measures and clinical variables in the EBA group. Conclusions. SBM is a useful method for detecting human brain structural abnormalities in blindness. The results showed that these structural abnormalities in the visual cortex and visual-related areas outside the occipital cortex in the EBAs not only may be influenced by neurodevelopment, degeneration, plasticity, and so on but also involved the interaction of these factors after the early visual deprivation.
期刊：
Information Sciences,2022年584:235-268 ISSN：0020-0255
通讯作者：
Liu, Wei;Xiong, Neal N.
作者机构：
[Wang, Han] Cent South Univ, Sch Comp Sci & Engn, Changsha, Hunan, Peoples R China.;[Liu, Wei] Hunan Univ Chinese Med, Sch Informat, Changsha 410208, Peoples R China.;[Xiong, Neal N.] Sul Ross State Univ, Dept Comp Sci & Math, Alpine, TX 79830 USA.;[Zhang, Shaobo] Hunan Univ Sci & Technol, Sch Comp Sci & Engn, Xiangtan, Hunan, Peoples R China.;[Wang, Tian] Beijing Normal Univ, Artificial Intelligence & Future Networks, Zhuhai, Guangdong, Peoples R China.
通讯机构：
[Liu, Wei] H;[Xiong, Neal N.] S;Hunan Univ Chinese Med, Sch Informat, Changsha 410208, Peoples R China.;Sul Ross State Univ, Dept Comp Sci & Math, Alpine, TX 79830 USA.
关键词：
Sensor based system;Duty cycle;Delay;Energy saving;Lifetime;Listen interval adaptive adjustment
摘要：
Due to the development of microprocessor technology, there are more than 20 billion sensor-based devices connected to the Internet of Things (IoT) to monitor physical phe-nomena and events. To reduce the energy used by idle listening, a low-duty cycle is often used in an event-sparse wireless sensor network. However, low-duty cycles bring large end-to-end delays. In this paper, a listen interval adaptive adjustment (LIAA) scheme is proposed to adjust the listen interval (LI) of a node to reduce end-to-end delays while maintaining the long lifetime of a network. The key idea is to make full use of the energy consumption imbalance in a network, to allow nodes away from the sink to use the resid-ual energy to add listen intervals. The LIAA scheme has 3 sub-strategies. One is the basic add listen interval (BALI) strategy, in which the parent node adds listen intervals in the fixed active slots of its child nodes. Another strategy is the consecutive listen (CL) scheme, which is based on BALI, and listen intervals are added consecutively. The third strategy is the random add listen interval (RALI) scheme, which uses the idea of randomness to add listen intervals. The extensive theoretical analysis and experimental results show that the LIAA scheme proposed in this paper has better performance. Compared with the tradi-tional scheme, the delays in the BALI scheme, CL scheme and RALI scheme were reduced by 24.03%, 23.45% and 39.41%, respectively, while the lifetime of the network was maintained. (c) 2021 Elsevier Inc. All rights reserved.
期刊：
Drug Design, Development and Therapy,2022年16:1621-1645 ISSN：1177-8881
通讯作者：
Qinhui Tuo
作者机构：
[Sun, Taoli; He, Chaoping; Quan, Wenjuan; Peng, Sha] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.;[Chen, Yu; Hu, Bo; Tuo, Qinhui; Yang, Dongmei] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Peoples R China.;[Liu, Jiaqin] Cent South Univ, Xiangya Hosp 1, Dept Pharm, Changsha 410011, Hunan, Peoples R China.;[Tuo, Qinhui] Hunan Univ Chinese Med, First Hosp, Changsha 410007, Peoples R China.
通讯机构：
[Qinhui Tuo] S;School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China<&wdkj&>The First hospital of Hunan University of Chinese Medicine, Changsha, 410007, People’s Republic of China
关键词：
Huo Luo Xiao Ling Dan;atherosclerosis;network pharmacology;molecular docking;molecular dynamics simulation;dihydrotanshinone I;STAT3;MAPK signaling pathway
摘要：
BACKGROUND: Vascular intimal hyperplasia (IH) is one of the key challenges in the clinical application of small-diameter vascular grafts. Current tissue engineering strategies focus on vascularization and antithrombotics, yet few approaches have been developed to treat IH. Here, we designed a tissue-engineered vascular scaffold with portulaca flavonoid (PTF) composition and biomimetic architecture. METHOD: By electrospinning, PTF is integrated with biodegradable poly(ε-caprolactone) (PCL) into a bionic vascular scaffold. The structure and functions of the scaffolds were evaluated based on material characterization and cellular biocompatibility. Human vascular smooth muscle cells (HVSMCs) were cultured on scaffolds for up to 14days. RESULTS: The incorporation of PTF and preparation parameters during fabrication influences the morphology of the scaffold, including fibre diameter, structure, and orientation. Compared to the PCL scaffold, the scaffolds integrated with bioactive PTF show better hydrophilicity and degradability. HVSMCs seeded on the scaffold alongside the fibres exhibit fusiform-like shapes, indicating that the scaffold can provide contact guidance for cell morphology alterations. This study demonstrates that the PCL/PTF (9.1%) scaffold inhibits the excessive proliferation of HVSMCs without causing cytotoxicity. CONCLUSION: The study provides insights into the problem of restenosis caused by IH. This engineered vascular scaffold with complex function and preparation is expected to be applied as a substitute for small-diameter vascular grafts.
期刊：
Journal of Advanced Nursing,2022年78(12):4071-4081 ISSN：0309-2402
通讯作者：
Jie Zhang<&wdkj&>Jingping Zhang
作者机构：
[Zhang, Jingping; Li, Juan; Yin, Yizhen] Cent South Univ, Xiangya Nursing Sch, Changsha 410013, Hunan, Peoples R China.;[Lyu, Mengmeng] Natl Univ Singapore, Alice Lee Ctr Nursing Studies, Yong Loo Lin Sch Med, Singapore, Singapore.;[Zuo, Man] Guangdong Prov Peoples Hosp, Dept Resp Med, Heyuan Branch, Heyuan, Peoples R China.;[Yao, Shuyu] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China.;[Li, Hui] Sichuan Univ, West China Hosp, Dept Orthoped, West China Sch Nursing, Chengdu, Peoples R China.
通讯机构：
[Jie Zhang] S;[Jingping Zhang] X;Xiangya Nursing School, Central South University, Changsha, P.R. China<&wdkj&>School of Nursing, Hunan University of Chinese Medicine, Changsha, P.R. China
关键词：
COVID-19;latent class analysis;nurses;work engagement
摘要：
AIM: The aim was to examine the subgroups of work engagement in frontline nurses during the COVID-19 pandemic. BACKGROUND: The pandemic may affect the work engagement of nurses who have direct contact with infected patients and lead to a poor quality of care. Identifying classification features of work engagement and tailoring interventions to support frontline nurses is imperative. DESIGN: This study utilized a cross-sectional study design. METHODS: Three hundred fifty-five nurses were enrolled in this cross-sectional study from 14 February to 15 April 2020. A latent profile analysis was performed to identify classification features of work engagement. Multiple logistic regression analyses were used to examine predictors of profile membership. RESULTS: A four-profile model provided the best fit. The four profiles were titled 'low work engagement' (n=99), 'high vigour-low dedication and absorption' (n=58), 'moderate work engagement' (n=63) and 'high work engagement' (n=135). A regression analysis suggested that young nurses and nurses who were the only children of their family were more likely to be in the 'low work engagement' and 'high vigour-low dedication and absorption' groups. CONCLUSION: This study highlights the importance of tailoring interventions for frontline supporting nurses by considering their distinct work engagement patterns, especially during the COVID-19 pandemic, to improve the promotion of work satisfaction and quality of care. IMPACT: This was the first study to explore the latent profiles of work engagement in frontline nurses during the COVID-19 pandemic. Over 40% of nurses were in the 'low work engagement' and 'high vigour-low dedication and absorption' groups and reported low levels of work engagement. Understanding different patterns of work engagement in frontline nurses can help nursing managers provide emotional, material and organizational support based on the features of each latent profile, which may improve the quality of care and patient safety.
作者机构：
[Tian, Miaomei; Li, You; Yan, Bingqian] Hunan Univ Chinese Med, Grad Sch, Changsha, Hunan, Peoples R China.;[Tian, Miaomei; Guo, Siwei; Xu, Bing; Li, You; Li, Xin; Yan, Bingqian] Third Hosp Changsha, 176 Western Laodong Rd, Changsha 410015, Hunan, Peoples R China.;[Guo, Siwei; Xu, Bing; Li, Xin] Inst Clin Applicat Antibiot, Changsha, Hunan, Peoples R China.;[Hu, Huangdu; Yu, Yunsong] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Infect Dis, Sch Med, Hangzhou, Peoples R China.;[Hu, Huangdu; Yu, Yunsong] Key Lab Microbial Technol & Bioinformat Zhejiang, Hangzhou, Peoples R China.
通讯机构：
[Xin Li] T;The Third Hospital of Changsha, Changsha, Hunan, PR China<&wdkj&>Institute of Clinical Application of Antibiotics, Changsha, Hunan, PR China
摘要：
Objectives: This study aimed to evaluate the in vitro synergy of polymyxin B (PMB) combined with 11 other antibiotics against PMB-resistant gram-negative bacilli (GNBs). Methods: Thirty-six clinical isolates of PMB-resistant GNBs were used. The MICs of all the antimicrobials tested were determined by the broth microdilution method and the checkerboard assay method. Carbapenemase genes were detected by PCR. In vitro synergy results were interpreted using the fractional inhibitory concentration index (FICI). Four combinations that showed positive interactions were subsequently evaluated in a time-kill study. Results: Among the 36 strains, 15 harboured the carbapenemase gene, and blaKPC was the predominant carbapenemase. The resistance rates of the 36 strains to tigecycline, meropenem, ceftazidime, and cefepime were 100% (36/36), 97% (35/36), 94% (34/36), and 97% (35/36), respectively. For Enterobacteriaceae and Pseudomonas aeruginosa, the resistance rates to aztreonam and ceftazidime-avibactam (avibactam at a fixed concentration of 4 mg/L) were 95% (19/20) and 25% (5/20), respectively. The PMB-based combinations exhibited synergism to a certain degree. The most synergistic combinations were PMB plus meropenem-avibactam (avibactam at a fixed concentration of 4 mg/L) and PMB plus tigecycline, with the synergy rates of 83.3% and 80.6%, respectively. Compared to tazobactam-and sulbactam-based beta-lactam beta-lactamase inhibitor combinations (BLBLIs), PMB with avibactam-based BL-BLIs exhibited a better synergistic effect. For Acinetobacter baumannii, PMB plus sulbactam exhibited a strong synergism with a 2 similar to 7-fold MIC reduction of PMB. In time-kill studies, the highest degree of synergism was observed for PMB with cefepime-avibactam on all the tested isolates. For isolates with low-level resistance to PMB, PMB combined with other partner antimicrobials also showed a certain degree of synergism. Conclusions: PMB in combination with tigecycline and avibactam-based BL-BLIs could be a potential clinical option for clinical treatment of infections caused by PMB-resistant GNBs.
作者机构：
[Ai, Qidi; Yao, Jiao; Zeng, Qi; Sun, Yang; Lin, Meiyu; Meng, Lei; Yang, Songwei; Yang, Yantao; Chen, Naihong; Long, Junpeng] Hunan Univ Chinese Med, Coll Pharm, Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Peoples R China.;[Liu, Shasha] Xiangtan Cent Hosp, Pharm Dept, Xiangtan 411100, Peoples R China.;[Chen, Chen] Lanzhou Univ, Dept Pharm, Hosp 1, Lanzhou 730000, Peoples R China.;[Yi, Fan] Beijing Technol & Business Univ, Key Lab Cosmet, China Natl Light Ind, Beijing 100048, Peoples R China.;[Chen, Naihong] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.
通讯机构：
[Naihong Chen; Qidi Ai] H;Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China<&wdkj&>Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China<&wdkj&>State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
期刊：
Frontiers in Endocrinology,2022年13:2153 ISSN：1664-2392
作者机构：
[Zhang, Ji-Dong; Li, Ling; Sun, Gui-Xiang; Qiu, Li-Ting; Fan, Bo-Yan] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha, Peoples R China.;[Sun, Gui-Xiang] Hunan Univ Chinese Med, Prov Key Lab Tradit Chinese Med TCM Diagnost, Changsha, Peoples R China.;[Sun, Gui-Xiang] Hunan Univ Chinese Med, Inst Chinese Med Diag, Changsha, Peoples R China.;[Wang, Dan] Hunan Univ Technol & Business, Sch Phys Educ & Hlth, Changsha, Peoples R China.
关键词：
eHealth;lifestyle interventions;Overweight and obesity;Children and adolescents;Meta-analysis
摘要：
Objective: To investigate the effect of multiple eHealth-delivered lifestyle interventions on obesity-related anthropometric outcomes in children and adolescents. Methods: The Medline (via PubMed), Embase, Cochrane Library, Web of Science, CBM, VIP, CNKI, and Wanfang electronic databases were systematically searched from their inception to March 18, 2022, for randomized controlled trials (RCTs). Meta-analyses were performed to investigate the effect of multiple eHealth-delivered lifestyle interventions on obesity-related anthropometric outcomes (body mass index [BMI], BMI Z-score, waist circumference, body weight, and body fat%). Two independent investigators reviewed the studies for accuracy and completeness. All included studies were evaluated using the Cochrane Risk-of-Bias (ROB) Tool. Results: Forty trials comprising 6,403 patients were selected for the meta-analysis. The eligible trials were published from 2006 to 2022. Compared with the control group, the eHealth-intervention group was more effective in reducing BMI (weighted mean difference [WMD] = -0.32, 95% confidence interval [CI]: -0.50 to -0.13, I-2 = 85.9%), BMI Z-score (WMD = -0.08, 95% CI: -0.14 to -0.03, I-2 = 89.1%), waist circumference (WMD = -0.87, 95% CI: -1.70 to -0.04, I-2 = 43.3%), body weight (WMD = -0.96, 95% CI: -1.55 to -0.37, I-2 = 0.0%), and body fat% (WMD = -0.59, 95% CI: -1.08 to -0.10, I-2 = 0.0%). The subgroup analysis showed that parental or school involvement (WMD = -0.66, 95% CI: -0.98 to -0.34), eHealth-intervention duration of > 12 weeks (WMD = -0.67, 95% CI: -0.96 to -0.38), and mobile-based interventions (WMD = -0.78, 95% CI: -1.13 to -0.43) had a significantly greater intervention effect size on BMI. Conclusions: This review recommends that multiple eHealth-delivered lifestyle strategies may be useful for preventing or treating overweight and obesity among children and adolescents. However, our results should be cautiously interpreted due to certain limitations in our study.
期刊：
Journal of Affective Disorders,2022年319:244-251 ISSN：0165-0327
通讯作者：
Xiongzhao Zhu
作者机构：
[Yu, Quanhao; Fan, Jie; Wang, Xiang; Liu, Qian; Lu, Jingjie; Zhu, Xiongzhao; Liu, Xingze; Gao, Feng; Han, Yan] Cent South Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha, Hunan, Peoples R China.;[Yu, Quanhao; Fan, Jie; Wang, Xiang; Liu, Qian; Lu, Jingjie; Zhu, Xiongzhao; Liu, Xingze; Gao, Feng; Han, Yan] Cent South Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China.;[Yu, Quanhao; Fan, Jie; Wang, Xiang; Liu, Qian; Lu, Jingjie; Zhu, Xiongzhao; Liu, Xingze; Gao, Feng; Han, Yan] Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China.;[Yao, Rui] Hunan Univ Chinese Med, Ctr Psychol Dev & Serv, Changsha, Hunan, Peoples R China.;[Zhu, Xiongzhao] Cent South Univ, Xiangya Hosp 2, Med Psychol Ctr, Renmin Middle Rd 139, Changsha 410011, Hunan, Peoples R China.
通讯机构：
[Xiongzhao Zhu] M;Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China<&wdkj&>Medical Psychological Institute of Central South University, Changsha, Hunan, China<&wdkj&>National Clinical Research Center for Mental Disorders, Changsha, Hunan, China
关键词：
Threat;Deprivation;Depressed mood;Anhedonia;Latent growth curve model
摘要：
Background/aim: There is growing awareness that specific childhood trauma (CT) may confer to the unique risk of depression, but little is known about this. The present study seeks to provide insight into how CT subtypes may impact distinct depressive symptoms over time based on the dimensional model of adversity (DMA).Methods: A total of 3535 college freshmen participated in a 2-year, four waves longitudinal tracking study. A conditional parallel latent growth curve model (LGCM) was constructed to examine the impacts of different types of CT (threat and deprivation) on the development of depressed mood and anhedonia, and whether these relationships vary across gender.Results: Our findings revealed that threat and deprivation could differentially relate to depressed mood and anhedonia. Both threat and deprivation predicted initial depressed mood levels (beta = 0.309, p < 0.001; beta = 0.175, p < 0.001, respectively) and its trajectory (beta = -0.139, p = 0.068; beta = -0.168, p < 0.05, respectively). Only deprivation predicted anhedonia levels (beta = 0.318, p < 0.001) and trajectory (beta = -0.218, p < 0.001). This pattern of relationships between CT and depressive symptoms varied across gender.Conclusion: These findings highlight specific pathways and symptomatic manifestations of the impacts of different CT subtypes on depression and are consistent with the hypothesis of DMA. Threat and deprivation predicted more severe depressed mood, whereas deprivation uniquely conferred to the risk of depression via elevated anhedonia. Meanwhile, the deleterious effects of CT would persist during early adulthood. Gender differences were also discussed.
摘要：
Kinesin family member 14 (KIF14) is potentially oncogenic and acts as a chromokinesin via binding to microtubules and chromatin during the bipolar spindle formation. KIF14 overexpression is a significant prognostic biomarker in various cancers. However, the expression, prognosis, mechanism, and tumor immune regulation of KIF14 in lung adenocarcinoma (LUAD) remain obscure. Our results demonstrated that KIF14 was upregulated in a variety of cancers, including LUAD. High-expression of KIF14 in LUAD was associated with pathological tumor stage, N stage and unfavorable prognosis. Both univariate and multivariate Cox regression results demonstrated that KIF14 was a significant independent risk factor influencing the prognosis of LUAD patients. The most promising upstream ncRNA-associated pathway of KIF14 in LUAD was determined to be GSEC/TYMSOS-hsa-miR-101-3p axis according to the starBase and The Cancer Genome Atlas databases. Furthermore, upregulation of KIF14 in LUAD was positively correlated with tumor mutation burden, microsatellite instability, immune checkpoint-related gene expression, immune cell biomarkers, and tumor immune cell infiltration. This study reveals that ncRNAs-mediated overexpression of KIF14 is associated with tumor immune infiltration and unfavorable prognosis in LUAD.
