摘要：
Objective(s): Previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. Naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (STZ)-induced diabetic rats. Recently, the effects of naringin on learning and memory performances were monitored in many animal models of cognitive impairment. However, to date, no studies have investigated the ameliorative effects of naringin on diabetes-associated cognitive decline (DACD). In this study, we investigated the effects of naringin, using a STZ-injected rat model and explored its potential mechanism. Materials and Methods: Diabetic rats were treated with naringin (100 mg/kg/d) for 7 days. The learning and memory function were assessed by Morris water maze test. The oxidative stress indicators [superoxide dismutase (SOD) and malondialdehyde (MDA)] and inflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6) were measured in hippocampus using corresponding commercial kits. The mRNA and protein levels of PPAR gamma were evaluated by real time (RT)-PCR and Western blot analysis. Results: The results showed that supplementation of naringin improved learning and memory performances compared with the STZ group. Moreover, naringin supplement dramatically increased SOD levels, reduced MDA levels, and alleviated TNF-alpha, IL-1 beta, and IL-6 compared with the STZ group in the hippocampus. The pretreatment with naringin also significantly increased PPAR gamma expression. Conclusion: Our results showed that naringin may be a promising therapeutic agent for improving cognitive decline in DACD.
作者机构：
[Wang, Jiali ; Tang, Jian ; Wang, Jue ; Yue, Ye ; Qin, Ling ] Center for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen 518055, China;[Wang, Jiali ; Qin, Ling ] Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong, Hong Kong;[ Wang, Kai ] School of Humanities and Social Sciences, Hunan University of Chinese Medicine, Changsha 410208, China;[ Li, Weirong ; Li, Yangde ] Guangdong Innovation Team for Biodegradable Magnesium and Medical Implants, E-ande, Dongguan 523660, China
通讯机构：
[Wang, Jiali] Center for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen 518055, China.
关键词：
Absorbable - Artificial bone materials - Electrochemical technology - Fourier transform infra reds - In-vitro - Internal fixation - Magnesium and its alloys - Scanning Electron Microscope
摘要：
Magnesium alloys have been advocated as potential artificial bone materials due to their biocompatibility and biodegradability. The understanding of their corrosive mechanism in physiological environments is therefore essential for making application-orientated designs. Thus, this in vitro study was designed to assess the effects of CO2 on corrosive behavior of AZ31D to mimic in vivo special ingredient. Electrochemical technologies accompanied with Scanning electron microscope, Fourier transform infrared, X-ray diffraction, Energy dispersive spectroscopy and hydrogen evolution measurement were employed to analyze corrosive rates and mechanisms of AZ31D. Moreover, the biocompatibility of AZ31D was assessed with a direct cell attachment assay and an indirect cytotoxicity test in different diluted extracts. The ion concentrations in extracts were measured using inductively coupled plasma mass spectrometry to offer explanations on the differences of cell viability in the indirect test. The results of the direct cytotoxicity assay showed that the corrosive rate of AZ31D was too rapid to allow for cell adhesion. Extracts diluted less than 20 times would cause adverse effects on cell proliferation, likely due to excessive ions and gas release. Moreover, the presence of CO2 did not cause significant differences on corrosive behavior of AZ31D according to the results of electrochemical testing and hydrogen evolution measurement. This might be caused by the simultaneous process of precipitation and dissolution of MgCO3 due to the penetration role of CO2. This analysis of corrosive atmospheres on the degradation behavior of magnesium alloys would contribute to the design of more scientific in vitro testing systems in the future. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
摘要：
We investigated the processing of self-related information under the prime paradigm using event-related potentials (ERPs) to provide evidence for implicit self-positivity bias in Chinese individuals. Reaction times and ERPs were recorded when participants made positive/negative emotional judgments to personality-trait adjectives about themselves or others. Faster responses occurred to self-related positive adjectives and other-related negative adjectives, indicating implicit self-positivity bias at the behavioral level. ERPs showed an interaction between prime and emotion at the P300 amplitude, with larger P300 amplitudes for words within the self-positivity bias, indicating that self-related information occupied more attentional resources. Larger N400 amplitudes elicited by words that were inconsistent with the self-positivity bias, suggesting that accessing non-self-relevant information is more difficult than self-relevant information. Thus, P300 and N400 could be used as neuro-indexes of the implicit self-positivity bias.
作者机构：
[Peng, Huan; Wang, Qichao; Li, Zhuang; Liu, Xianchu; Gong, Jingbo; Chen, Jiaxue; Mo, Yanzhi; Ke, Zhaowen] Department of Applied Psychology, Hunan University of Chinese Medicine, Hunan, People's Republic of China;[Xie, Jingtao] Department of Applied Psychology, Hunan University of Chinese Medicine, Hunan, People's Republic of China. xiejingtao516@163.com
通讯机构：
[Xie, Jingtao] Department of Applied Psychology, Hunan University of Chinese Medicine, Hunan, People's Republic of China.
摘要：
Previous research has indicated that Diabetes is a high risk of learning and memory deficits. Puerarin, an isoflavonoid extracted from Kudzu roots, has been reported to possess antioxidant, anti-inflammatory, anti-apoptotic and anti-diabetic properties which are useful in the treatment of various diseases. Recently, Puerarin was found to have the effects on learning and memory performances in humans and animal models. However, up to now, there is no detailed evidence on the effect of Puerarin on diabetes-associated cognitive decline (DACD). In this study, we designed to assess the effects of Puerarin on diabetes-associated cognitive decline (DACD) using a streptozotocin (STZ)-injected rat model and exploring its potential mechanism. Diabetic rats were treated with Puerarin (100 mg/kg per d) for 7 days. The learning and memory function was evaluated by morris water maze test. The acetylcholinesterase (AChE), choline acetylase (ChAT), oxidative indicators [malondialdehyde (MDA) and superoxide dismutase (SOD)] and inflammatory cytokine (TNF-a, IL-1beta and IL-6) were measured in hippocampus by using corresponding commercial kits. mRNA and Protein levels of Bcl-2 were analyzed by RT-PCR and Westernblot. The results showed that supplementation of Puerarin improved the learning and memory performances compared with the STZ group by the morris water maze test. In addition, Puerarin supplement significantly prevented AChE and MDA activities, increased ChAT and SOD activities, and alleviated the protein level of TNF-alpha, IL-1beta and IL-6 in the hippocampus compared with the STZ group. Moreover, the pretreatment with Puerarin also significantly increased the Bcl-2 expression. It is concluded that Puerarin possesses neuroprotection to ameliorate cognitive deficits in streptozotocin-induced diabetic rats by anti-inflammatory, antioxidant and antiapototic effects.
期刊：
International journal of psychophysiology : official journal of the International Organization of Psychophysiology,2016年112:46-51 ISSN：0167-8760
通讯作者：
Xie, Guangrong
作者机构：
[Xie, Guangrong] Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China. Electronic address: xiegrpsy@126.com;[Yang, Tian-xiao; Wang, Yi] Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China;[Tan, Changlian; Cui, Xilong; Guo, Wenbin] Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China;[Gong, Jingbo; Wang, Yefei] Department of Applied Psychology, Hunan University of Chinese Medicine, Changsha, Hunan, China;[Yang, Xin-hua] Institute of Education, Hunan Agricultural University, Changsha, Hunan, China
通讯机构：
[Xie, Guangrong] Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China. Electronic address:
关键词：
Melancholic major depressive disorder;Default mode network;Network homogeneity;Resting-state imaging
摘要：
Background: Melancholic depression is a relatively homogenous subtype of major depressive disorders (MDD). The condition has several endogenous symptoms and represents strong biological components. However, its specific neurobiological mechanisms remain unknown. Previous neuroimaging findings indicated that default mode network (DMN) is closely related to MDD. The present study examined the network homogeneity (NH) of the DMN in patients with melancholic MDD. Methods: A total of 33 first-episode, treatment-naive melancholic MDD patients and 32 healthy controls underwent a resting-state functional magnetic resonance imaging scan. The data were analyzed using the NH method. Results: Compared with healthy controls, patients with melancholic MDD showed low NH values in the right middle temporal gyrus and temporal pole (MTG/FP). The abnormal NH of this region and clinical characteristics were not correlated. Conclusion: Abnormal NH pattern of DMN exists in patients with melancholic MDD. This feature may be part of the pathophysiological basis of this disorder. (C) 2016 Elsevier B.V. All rights reserved.
通讯机构：
[Luo, Xuerong] Mental Health Institute of the Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China. Electronic address:;Cent S Univ, Xiangya Hosp 2,China Natl Clin Res Ctr Mental Hlt, Key Lab Psychiat & Mental Hlth Hunan Prov, Natl Technol Inst Psychiat,Mental Hlth Inst, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.
摘要：
Background: Relationships of some types of childhood maltreatment and suicidal behavior remain controversial and inconclusive. Methods: Medline, Embase, PsycINFO and Cochrane library were searched for eligible studies, and the results were synthesized in meta-analyses. Results: childhood maltreatment was associated positively with suicidal behavior in the total population and maltreatment subgroups. Emotional abuse had the strongest effect (OR = 2.33, SMD = 0.660, P < 0.001). Subgroup analyses showed that the effects of childhood abuse (OR = 1.55, SMD = 0.523) and neglect (OR = 1.25, SMD = 0.31) were significant. According to the analysis of dichotomous outcomes, childhood maltreatment was associated positively with suicidal behavior in men and women (women: OR = 4.84, P < 0.001; men: OR = 1.03, P < 0.001). Among populations, childhood maltreatment had the strongest effect on suicidal behavior in the general population (OR = 3.78, P < 0.001). However, the analysis of continuous outcomes showed that the effect was strongest in patients with chronic schizophrenia (SMD = 0.89, P < 0.001). In addition, childhood maltreatment was associated positively with suicide attempt (OR = 1.11, SMD = 0.48, P < 0.001), but not with suicidal ideation. Limitations: Some subgroup samples were not sufficiently large. Conclusions: Childhood maltreatment increases the risk of suicidal behavior. Emotional abuse had the strongest effect among the five types of maltreatment. The risk of suicidal behavior is higher in the general population, women, and individuals with chronic schizophrenia who have histories of childhood maltreatment.
作者机构：
[Zhang, Yajie; Xie, Jingtao; Gong, Jingbo] Department of Applied Psychology, Traditional Chinese Medicine University of Hunan, Changsha 410208, Hunan, China;[Wang, Suhong] Department of Neuroscience, The Third Affiliated Hospital of Soochow University, Juqian Road No. 185, Changzhou 213003, China. Electronic address: yarmine@gmail.com;[Chen, Gui] Department of Social Medicine and Health Management, School of Public Health, Central South University, Changsha, Hunan, China
通讯机构：
[Wang, Suhong] Department of Neuroscience, The Third Affiliated Hospital of Soochow University, Juqian Road No. 185, Changzhou 213003, China. Electronic address:
关键词：
ADHD;NSS;CNI;BRIEF
摘要：
The correlations between neurological soft signs (NSS) in children with attention deficit hyperactivity disorder (ADHD) and their executive function, symptoms of inattention, and hyperactivity-impulsivity and the NSS of their parents remain unclear. This study aimed to examine: (1) the prevalence of NSS in children with ADHD and their parents; (2) the correlation between the NSS of children with ADHD and the NSS of their parents; and (3) the correlation between the NSS of children with ADHD and their executive function and symptoms. NSS were assessed with the Cambridge Neurological Inventory (CNI) in 57 children with ADHD (and 80 parents) and 60 healthy children (and 75 parents). Executive function was measured with the Behavioral Rating Inventory of Executive Function (BRIEF). Children with ADHD and their parents had significantly higher NSS than normal children and their parents, respectively, and the NSS of children with ADHD were correlated more strongly with the NSS of their fathers than their mothers. No correlation was found between NSS and BRIEF executive function, but Disinhibition in children with ADHD was significantly correlated with hyperactivity-impulsivity symptoms. Paternal and maternal NSS provided different predictions for child NSS. It may be that NSS are more likely to be genetically transmitted by fathers. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
摘要：
We examined emotional eating among undergraduates in China. The Emotional Eating Scale (EES; Arnow, Kenardy, & Agras, 1995) was translated into Chinese and adapted to assess intensity and frequency of eating in response to different emotions. A factor analysis generated 4 subscales of emotions for which eating is a response: anxiety, depression, anger/hostility, and positive emotion. Internal consistency reliability for the subscales was established (Cronbach's alpha = .817, .852, .832, and .861, respectively). Moderate correlations were found between all subscales, eating pathology, and impulsive control. Positive emotion and negative emotion were found to play an important role in eating behavior. As there was a strong relationship between emotional eaters, especially negative emotional eaters, and eating psychopathology, these individuals may be at high risk of developing an eating disorder and/or becoming obese.
摘要：
The current study investigated the moderating effects of gender, age, and weight status on the relationship between body dissatisfaction and depression among adolescents. Data were collected on body dissatisfaction, depression, and demographic characteristics from a convenience sample of 1,101 adolescents (505 girls, 596 boys). The relationship between body dissatisfaction and depression differed significantly by weight status (beta = 0.318, p < .01), but not gender or age. In addition, their association varied across weight status only in males (beta s = 0.501, 0.240, and 0.178 for underweight, normal weight, and overweight respectively, ps < .05) and the early adolescence group (beta s = 0.523, 0.282, 0.297 for underweight, normal weight, and overweight respectively, ps < .01). The findings indicated that the association of body dissatisfaction with depression was significant among nearly all weight-status groups of adolescents, and varied across weight status among males and early adolescence groups. This suggests that the prevention programs that aim to reduce depression by reducing body dissatisfaction in adolescents should include all weight-status groups, and pay close attention to underweight adolescents (especially underweight boys and early adolescents who are underweight).
摘要：
We examined the roles of negative coping, positive coping, and self-esteem as mediators of the relationship between maladaptive perfectionism and depression with a sample of 412 Chinese undergraduates. Participants completed measures of perfectionism and it was found that negative coping and positive coping both partially mediated the association between maladaptive perfectionism and depression. The final model also revealed that positive coping partially mediated the relationship between maladaptive perfectionism and self-esteem. Implications for counseling interventions and future research are discussed.
作者机构：
[Liu, Jianbo; He, Yuqiong; Xiao, Bo; Shen, Yanmei; Luo, Xuerong] 湖南中医药大学，Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410000, Hunan, Peoples R China.;[Liu, Jianbo; He, Yuqiong; Xiao, Bo; Shen, Yanmei; Luo, Xuerong; Luo, XR (reprint author)] Cent S Univ, Key Lab Psychiat & Mental Hlth Hunan Prov, Changsha 410000, Hunan, Peoples R China.;[Gong, Jingbo] Tradit Chinese Med Univ Hunan, Dept Appl Psychol, Changsha 410208, Hunan, Peoples R China.;[Nie, Guanghui] Guangxi Med Univ, Sch Publ Hlth, Nanning 530000, Peoples R China.;[Luo, XR (reprint author)] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410000, Hunan, Peoples R China.
通讯机构：
[Luo, XR] Cent S Univ, Key Lab Psychiat & Mental Hlth Hunan Prov, Changsha 410000, Hunan, Peoples R China.;Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410000, Hunan, Peoples R China.
关键词：
APT;SPT;Neglect;Depression;Mediating factor
摘要：
Background: Autistic personality traits (APT) and schizotypal personality traits (SPT) are associated with depression. However, mediating factors within these relationships have not yet been explored. Thus, the focus of the current study was to examine the effects of childhood neglect on the relationship between APT/SPT and depression. Methods: This cross-sectional study was conducted on first-year students (N = 2469) at Hunan University of Chinese Medicine and Hengyang Normal College (Changsha, China). Participants completed surveys on APT, SPT, childhood neglect, abuse and depression. Results: Through correlational analyses, APT and SPT traits were positively correlated with childhood neglect and depression (p < 0.05). In a hierarchical regression analysis, among types of childhood maltreatment, emotional neglect (beta = 0.112, p < 0.001) and physical neglect (beta = 0.105, p < 0.001) were the strongest predictors of depression. Childhood neglect did not account for the relationships between APT/SPT and depression. Further analysis found that childhood neglect mediated the relationship between SPT and depression but not APT and depression. Conclusions: Among types of childhood maltreatment, neglect was the strongest predicting factor for depression. Neglect did not account for the relationship between APT/SPT and depression but was a strong mediating factor between SPT and depression.
摘要：
The aim of the study was to examine the nature of perfectionism, to gain a better understanding of the construct using the Chinese population. The study also explored the relationships between perfectionism, self-esteem and depression after identifying the three dimensions of perfectionism. A sample of 292 Chinese university students completed the Frost Multidimensional Perfectionism Scale (FMPS), the Hewitt Multidimensional Perfectionism Scale (HMPS), the Almost Perfect Scale Revised (APS-R), the Self-Esteem Scale (SES), and the Beck Depression Inventory (BDI). As hypothesised, the confirmatory factor analyses revealed that multidimensional perfectionism is explained as a three-factor construct with dimensions of maladaptive perfectionism, adaptive perfectionism and order factor. As predicted, the structural equation model analyses indicated that self-esteem partially mediated the relationship between maladaptive perfectionism and depression. Implications for counselling interventions and future research are discussed.
摘要：
We evaluated the reliability and validity of Wong's Emotional Intelligence Scale (WEIS) - a forced-choice emotional intelligence scale - with a sample of 271 Chinese nurses employed at 2 large hospitals in the Hunan Province of China. The results demonstrated that the WEIS did not fit a 4-factor structure and the scale had acceptable reliability and convergent, discriminant, and predictive validity. Although our results in this study support the practical utility of the WEIS with Chinese nurses, our results suggest the need for further validation of the WEIS.
