作者机构：
[江建锋; 游柏稳; 白强] Department of Geriatrics, The Second Hospital of Hunan University of Chinese Medicine, Changsha, 410005, China;[成绍武; 贺春香; 宋祯彦] Hunan Key Laboratory of Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[You, B.-W.] D;Department of Geriatrics, China
作者机构：
[Eckert G.P.] Institute of Nutritional Sciences, Laboratory for Nutrition in Prevention and Therapy, Justus-Liebig-University of Giessen, Biomedical Research Center Seltersberg (BFS), Giessen, 35390, Germany;[Shao-Wu C.; Zhen-Yan S.] The Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
通讯机构：
[Gunter P. Eckert] I;Institute of Nutritional Sciences, Laboratory for Nutrition in Prevention and Therapy, Justus-Liebig-University of Giessen, Biomedical Research Center Seltersberg (BFS), Giessen, 35390, Germany
作者机构：
[王彦婷; 陈易璇; 谢丽风; 李园园] Hunan University of Chinese Medicine, Changsha, 410208, China;[余婧萍; 贺春香] Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, 410208, China;[郭艳幸] Luoyang Orthopedic-Traumatological Hospital of Henan Province, Luoyang, 471002, China;[宋祯彦] Hunan University of Chinese Medicine, Changsha, 410208, China, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, 410208, China;[易亚乔] Hunan University of Chinese Medicine, Changsha, 410208, China, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, 410208, China, Luoyang Orthopedic-Traumatological Hospital of Henan Province, Luoyang, 471002, China
通讯机构：
[Song, Z.-Y.] H;Hunan University of Chinese MedicineChina
作者机构：
[成绍武; 陈易璇; 贺旭; 余婧萍; 宋祯彦] Key Laboratory of Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases of Hunan Provinc, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
通讯机构：
[Cheng, S.-W.] K;Key Laboratory of Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases of Hunan Provinc, China
作者机构：
[Shaowu Cheng; Zhenyan Song; Shanshan Wang; Fang Yin; Xiaodan Liu; Fuzhou Li; Ping Li; Jinwen Ge] Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine
会议名称：
中国神经科学学会第十二届全国学术会议
会议时间：
2017-10-12
会议地点：
中国天津
会议论文集名称：
中国神经科学学会第十二届全国学术会议论文集
关键词：
Protein prenylation;Synaptic plasticity;Metabolic syndrome;DangguiShaoyao-San
摘要：
Metabolic syndrome（MS） is an important risk factor for the cognitive dysfunction of Alzheimer’s disease（AD）, but its exact mechanism has not been elucidated. Lots of researches showed that both the MS and AD, which are closely related with "phlegm congestion turbid evil" in Chinese medicine, exist correlation with protein prenylation translational modifications（PPTM）. Our previous studies confirmed that regulating protein PPTM levels could enhance synaptic plasticity and improve the cognitive function in AD animal model. In this study, we investigated the connection between PPTM protein and cognitive dysfunction induced by glucose and lipid metabolism disorder combined with Abeta, and intervened by the traditional Chinese Medical prescription based on the method of "conditioning liver and spleen and improving phlegm and blood stasis", and identified the PPTM protein of synaptic plasticity in MS combined with Abeta. We found that the abnormal PPTM protein is the main reason for glucose and lipid metabolism disorder in AD brain and related nerve damage on the cognitive loop, and the traditional Chinese Medical prescription based on the method of "conditioning liver and spleen" can regulate protein level of PPTM to improve the cognitive function of AD. This study showed the scientific connotation of the pathogenesis of "cognitive dysfunction by phlegm and blood stasis" in AD and lead to the discovery of other novel therapeutic targets for AD.
作者机构：
[Shao-wu Cheng; Huai-gang Qu; Xiao-dan Liu; Zhen-yan Song; Ping Li; Hong-wen He; Jin-wen Ge] College of integrated Traditional Chinese Medicine and Western Medicine,Hunan University of Chinese Medicine,Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases;[Shao-wu Cheng; Huai-gang Qu; Xiao-dan Liu; Zhen-yan Song; Ping Li; Hong-wen He; Jin-wen Ge] Department of Anatomy,Zhongshan School of Medicine,Sun Yat-sen University;[Shao-wu Cheng; Huai-gang Qu; Xiao-dan Liu; Zhen-yan Song; Ping Li; Hong-wen He; Jin-wen Ge] Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology
会议名称：
第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议
会议时间：
2015-09-20
会议地点：
中国浙江桐乡
摘要：
Danggui-Shaoyao-San(DSS),a traditional Chinese medicinal prescription,could alleviate cognitive dysfunction of Alzheimer’s disease(AD) patients.However,the detail mechanisms remain elusive.In the pres
