期刊：
Archives of Osteoporosis,2020年15(1):1-8 ISSN：1862-3522
通讯作者：
Liang, Hao
作者机构：
[He, Bing; Wang, Haijiao; Shi, Jianwei; Zhang, Yonghui] Luohe Cent Hosp, Dept Orthopaed, Luohe 462000, Henan, Peoples R China.;[Liang, Hao] Hunan Univ Chinese Med, Inst TCM Diagnost, 300 Xueshi Rd,Sci Educ Ind Pk, Changsha 410208, Hunan, Peoples R China.;[Liang, Hao] Hunan Univ Chinese Med, Hunan Prov Key Lab TCM Diagnost, 300 Xueshi Rd,Sci Educ Ind Pk, Changsha 410208, Hunan, Peoples R China.
通讯机构：
[Liang, Hao] H;Hunan Univ Chinese Med, Inst TCM Diagnost, 300 Xueshi Rd,Sci Educ Ind Pk, Changsha 410208, Hunan, Peoples R China.;Hunan Univ Chinese Med, Hunan Prov Key Lab TCM Diagnost, 300 Xueshi Rd,Sci Educ Ind Pk, Changsha 410208, Hunan, Peoples R China.
关键词：
*Atherosclerosis;*Bone mineral density;*Coronary artery disease;*Meta-analysis;*Osteoporosis
摘要：
A meta-analysis was performed to explore the association of coronary artery disease (CAD) with bone mineral density (BMD). Low BMD was not found to be associated with prevalence of CAD. Though the BMD of CADs is significantly lower than that of non-CADs, the confounding effect of aging could not be excluded as CADs might be more prevalent in older patients. PURPOSE/INTRODUCTION: The clinical association of coronary artery disease (CAD) with bone mineral density (BMD) has been increasingly reported, but findings on the relationship between the two age-related processes are conflicting. The aim of our study was to conduct a meta-analysis to evaluate the associations between CAD and BMD. METHODS: We searched PubMed, Embase, and Cochrane Library. Odds ratio (OR) and 95% confidence interval (CI) were pooled to assess the association between low BMD and the prevalence of CAD. For continuous data, standardized mean difference (SMD) with its 95% CI was pooled. Correlation coefficients of BMD and Gensini score were pooled after being transformed by Fischer z-transformation. Subgroup and meta-regression analyses were performed to explore the sources of heterogeneity. RESULTS: The meta-analysis involved 4170 participants from 11 studies. Pooled ORs for the incidence of CAD in patients with low BMD versus patients with normal BMD was 1.58 (95% CI 0.99-2.52, P = 0.06), and no statistical difference was found in men and women subgroups. After confounding age, the combined OR was 1.60 (95% OR 0.69-3.72, P = 0.27). Pooling data for comparing BMD of CADs and non-CADs were - 0.28 (95% CI - 0.47 to - 0.09, P = 0.004) in femoral neck and calcaneus, - 0.42 (95% CI - 0.89-0.05, P = 0.08) in lumbar spine, and - 0.25 (95% CI - 0.40 to - 0.11, P = 0.000) in the overall. A significance was detected in pooled correlation analysis between CAG Gensini score and BMD (COR = - 0.4435 [- 0.6647; - 0.1508], P = 0.004). No sources of heterogeneity were acquired, and no publication bias was identified. CONCLUSIONS: Low BMD was not associated with the prevalence of CAD. Without age adjustment, the BMD of CADs is significantly lower than that of non-CADs, and the patients with lower BMD are inclined to more severe coronary artery lesions.
作者机构：
[邓乐; 梁力伟; 丁长松; 黄辛迪] School of Informatics and Engineering, Hunan University of Chinese Medicine, Changsha, 410208, China;[梁昊] Institute of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[Ding, C.-S.] S;School of Informatics and Engineering, China
关键词：
药向量;中药药性量化;BP神经网络;药性数据;功效
摘要：
目的 为解决中药药性描述的抽象、模糊导致难以准确把握其本质特性的问题,提出一种基于多层前馈神经网络(BP 神经网络)的药向量训练(quantitative model of traditional Chinese medicine's properties based on BP neural network,QM-BP)模型,实现中药药性的量化表示.方法 首先对中药及其对应的功效进行整理,获得“中药-功效”样本对;其次,构建“中药-药向量-功效”3层结构的QM-BP模型,并利用中药的药性数据对模型进行初始化;最后,基于QM-BP模型使用“中药-功效”样本进行训练,得到BP药向量.结果 将《中药学》教材所涉及的474味中药及其528个功效基于QM-BP模型训练并结合临床分析,发现训练后得到的BP药向量比药性的初始量化值更能反映中药的属性特征.此外,由于BP药向量与词向量具有相似的性质,发现功效相似的药物对应的BP药向量在欧几里得距离中距离较近,而功效差异较大的中药药向量在欧几里得距离中距离较远.结论 利用BP神经网络构建药向量训练模型,在中药药性与功效具有关联性的基础上,对药性量化值进行修正,以期使药性量化值更精确.今后可优化QM-BP模型并开展药对、复方分析,以期探明中药药性及组方配伍中蕴藏的内在规律.
作者：
Du, Qing;He, Dan;Zeng, Hong-Liang;Liu, Jian;Yang, Hui;...
期刊：
Journal of Ethnopharmacology,2020年262:113160 ISSN：0378-8741
通讯作者：
Cai, Ping;Huang, Jian-hua;Zhang, Shui-han
作者机构：
[Zhang, Shui-han; Wan, Dan; Cai, Ping; Huang, Jian-hua; Zhang, SH; Du, Qing; He, Dan; Zeng, Hong-Liang; Xu, Lin-Ben] Hunan Univ Chinese Med, Hunan Acad Chinese Med, Changsha 410013, Hunan, Peoples R China.;[Yang, Hui; Liu, Jian] Hunan Univ Chinese Med, Cent Lab, Hosp 1, Changsha 410007, Hunan, Peoples R China.;[Liang, Hao] Hunan Univ Chinese Med, Inst TCM Diagnost, Changsha 410208, Hunan, Peoples R China.;[Tang, Chun-Yu] Hunan Times Sunshine Pharmaceut Co Ltd, Changsha 410208, Hunan, Peoples R China.
通讯机构：
[Cai, P; Huang, JH; Zhang, SH] H;Hunan Univ Chinese Med, Hunan Acad Chinese Med, Changsha 410013, Hunan, Peoples R China.
摘要：
ETHNOPHARMACOLOGICAL RELEVANCE: Siwu Paste (SWP) was recorded in the first national Pharmacopoeia of China, "Tai Ping Hui Min He Ji Ju Fang", it showed excellent effects in regulating all syndromes relevant to blood. AIM OF THE STUDY: This study aimed to investigate the protective effects of Siwu Paste (SWP) on bone marrow hematopoietic by using rats' model with blood deficiency syndrome induced by chemotherapy. MATERIALS AND METHODS: Animal model with blood deficiency syndrome was successfully established by evaluating their peripheral blood cell level and erythrocyte membrane energy metabolism enzyme activity. Serum hematopoietic cytokine levels were detected by using Enzyme-linked immunosorbent assay (ELISA). Hematoxylin-Eosin (HE) staining method was used to observe the pathological morphology of femur bone marrow, and the viability of BMSC was detected by Cell Counting Kit (CCK-8). Furthermore, the expression of toll-like receptor 4 (TLR4), nuclear transcription factor kB (NF-κB), and NOD-like receptor protein 3 (NLRP3) protein in femur bone marrow were detected by using Western-blotting and High-content cell imaging analysis system (HCA). RESULTS: Obtained results showed that SWP could significantly improve the status of anemia, regulate the expressions of serum hematopoietic cytokines, and protect bone marrow hematopoietic cells. Furthermore, the expressions of TLR4, NF-κB, and NLRP3 protein were inhibited in bone marrow hematopoietic cells. CONCLUSIONS: Siwu Paste (SWP) could recover the bone marrow hematopoietic functions in rats with blood deficiency syndrome. The therapeutic mechanism may be related to the regulation of serum hematopoietic cytokines, and inhibition of TLR4/NF-κB/NLRP3 signaling pathway.
作者机构：
[Shi-Wei X.; Xin-Di H.; Chang-Song D.; Li-Song L.] School of Informatics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;[Hao L.] Institute of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
通讯机构：
[Ding Chang-Song] S;School of Informatics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
