摘要：
目的：探讨宫腔镜检查诊断异常子宫出血（AUB）的临床价值。方法选择2012年10月—2015年10月于湖南省中医药研究院附属医院院进行治疗的100例 AUB 患者，均进行 B 超检查及宫腔镜检查，比较两种检查的诊断准确率。结果宫腔镜检查诊断正确率高于 B 超，差异有统计学意义（P ﹤0.05）。结论宫腔镜检查诊断AUB 的效果较为明显，可以在很大程度上提高诊断准确率，使患者得到及时治疗，为患者生活质量提供保障。
作者机构：
[Li, Chun-yu] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 610000, Peoples R China.;[Zhang, Ya-ming; Yan, Dan; Li, Qi; Zhao, Yan-ling; Li, Chun-yu; Wang, Zhe-wei; Tu, Can; Jiang, Bing-qian; Zeng, Ling-na; Wang, Jia-bo] 302 Mil Hosp, China Mil Inst Chinese Med, Beijing 100039, Peoples R China.;[Ma, Zhi-jie; Li, Qi] Capital Med Univ, Dept Tradit Chinese Med, Beijing Friendship Hosp, Beijing 100050, Peoples R China.;[Zhang, Ping] 302 Mil Hosp, Integrat Med Ctr, Beijing 100039, Peoples R China.;[Tan, Rui; Wang, Zhe-wei] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China.
通讯机构：
[Wang, Jia-bo] 3;302 Mil Hosp, China Mil Inst Chinese Med, Beijing 100039, Peoples R China.
关键词：
Powder needleless injection;Insulin;Transdermal drug delivery;Skin irritation
摘要：
Insulin is widely used in treating diabetes, but still needs to be administered by needle injection. This study investigated a new needle-free approach for insulin delivery. A portable powder needleless injection (PNI) device with an automatic mechanical unit was designed. Its efficiency in delivering insulin was evaluated in alloxan-induced diabetic rabbits. The skin irritation caused by the device was investigated and the results were analyzed in relation to aerodynamic parameters. Inorganic salt-carried insulin powders had hypoglycemic effects, while raw insulin powders were not effective when delivered by PNI, indicating that salt carriers play an important role in the delivery of insulin via PNI. The relative delivery efficiency of phosphate-carried insulin powder using the PNI device was 72.25%. A safety assessment test showed that three key factors (gas pressure, cylinder volume, and nozzle distance) were related to the amount of skin irritation caused by the PNI device. Optimized injection conditions caused minimal skin lesions and are safe to use in practice. The results suggest that PNI has promising prospects as a novel technology for delivering insulin and other biological drugs.
